ANCC FNP Exam Version 2 Prep-Family Nurse Practitioner
Practice Questions & Answers 3 versions
This specialized clinical test-preparation guide delivers high-yield practice questions and
verified answers modeled directly after Version 2 of the ANCC Family Nurse Practitioner
board certification exam. It thoroughly covers advanced practice competencies,
including differential diagnosis formulation, evidence-based pharmacotherapeutic
management, healthcare policy, and the consensus model for advanced practice
registered nurses. Family Nurse Practitioner candidates will master complex multi-
system clinical assessment patterns and theoretical nursing frameworks to confidently
pass their national board evaluation.
1. A 68-year-old male presents with sudden onset of painless monocular vision
loss lasting 15 minutes, now resolved. Which condition should the FNP suspect?
A) Migraine with aura
B) Amaurosis fugax
C) Retinal detachment
D) Acute angle-closure glaucoma
Rationale: Transient monocular vision loss (amaurosis fugax) is a TIA of the retina and a
warning sign of impending stroke; immediate evaluation for carotid stenosis and
anticoagulation is needed.
2. A 42-year-old female presents with fatigue, weight gain, and cold intolerance.
Her TSH is elevated and free T4 is low. Which medication is first-line?
A) Methimazole
B) Levothyroxine
C) Radioactive iodine
D) Propranolol
Rationale: Levothyroxine is the standard treatment for primary hypothyroidism; dose is
titrated to normalize TSH.
,3. A 55-year-old male with COPD presents with increased dyspnea and purulent
sputum. Which action is most appropriate?
A) Increase oxygen to 6 L/min
B) Prescribe antibiotics
C) Start high-dose inhaled corticosteroids
D) Order chest X-ray only
Rationale: Purulent sputum in COPD indicates bacterial exacerbation; antibiotics are
indicated along with bronchodilators.
4. A 28-year-old female at 10 weeks gestation reports severe nausea and vomiting.
Which medication is first-line?
A) Ondansetron
B) Doxylamine-pyridoxine
C) Metoclopramide
D) Promethazine
Rationale: Doxylamine-pyridoxine is first-line for nausea and vomiting of pregnancy per
ACOG guidelines.
5. A 70-year-old male presents with sudden painless vision loss in one eye. Which
condition should the FNP suspect?
A) Glaucoma
B) Central retinal artery occlusion
C) Cataracts
D) Macular degeneration
Rationale: Sudden painless vision loss suggests central retinal artery occlusion; an
ophthalmologic emergency.
,6. A 50-year-old female has a fasting glucose of 118 mg/dL. Which diagnosis is
correct?
A) Normal
B) Pre-diabetes
C) Diabetes mellitus
D) Hypoglycemia
Rationale: Fasting glucose 100–125 mg/dL indicates pre-diabetes; lifestyle modification is
first-line.
7. A 35-year-old male presents with urethral discharge and dysuria. Which
organism is most likely?
A) E. coli
B) Chlamydia trachomatis
C) Staphylococcus aureus
D) Candida albicans
Rationale: Chlamydia is a common cause of urethritis in young males; treat with
azithromycin or doxycycline.
8. A 65-year-old female has a BMI of 32. Which classification is correct?
A) Normal weight
B) Overweight
C) Obesity class I
D) Obesity class II
Rationale: BMI 30–34.9 is classified as obesity class I.
9. A 40-year-old male presents with episodic headaches, palpitations, and
diaphoresis. Which condition should the FNP suspect?
A) Anxiety
B) Pheochromocytoma
, C) Hyperthyroidism
D) Carcinoid syndrome
Rationale: Episodic headaches, palpitations, and diaphoresis suggest pheochromocytoma;
check plasma metanephrines.
10. A 55-year-old female has a new diagnosis of hypothyroidism. Which lab
finding is expected?
A) Low TSH, high T4
B) High TSH, low T4
C) High TSH, high T4
D) Low TSH, low T4
Rationale: Primary hypothyroidism causes elevated TSH and low free T4.
11. A 60-year-old male presents with resting tremor, rigidity, and bradykinesia.
Which diagnosis is correct?
A) Essential tremor
B) Parkinson's disease
C) Multiple sclerosis
D) Huntington's disease
Rationale: Resting tremor, rigidity, and bradykinesia are classic for Parkinson's disease;
treat with levodopa-carbidopa.
12. A 25-year-old female presents with malar rash and photosensitivity. Which
condition should the FNP suspect?
A) Rosacea
B) Systemic lupus erythematosus
C) Dermatomyositis
D) Psoriasis
Practice Questions & Answers 3 versions
This specialized clinical test-preparation guide delivers high-yield practice questions and
verified answers modeled directly after Version 2 of the ANCC Family Nurse Practitioner
board certification exam. It thoroughly covers advanced practice competencies,
including differential diagnosis formulation, evidence-based pharmacotherapeutic
management, healthcare policy, and the consensus model for advanced practice
registered nurses. Family Nurse Practitioner candidates will master complex multi-
system clinical assessment patterns and theoretical nursing frameworks to confidently
pass their national board evaluation.
1. A 68-year-old male presents with sudden onset of painless monocular vision
loss lasting 15 minutes, now resolved. Which condition should the FNP suspect?
A) Migraine with aura
B) Amaurosis fugax
C) Retinal detachment
D) Acute angle-closure glaucoma
Rationale: Transient monocular vision loss (amaurosis fugax) is a TIA of the retina and a
warning sign of impending stroke; immediate evaluation for carotid stenosis and
anticoagulation is needed.
2. A 42-year-old female presents with fatigue, weight gain, and cold intolerance.
Her TSH is elevated and free T4 is low. Which medication is first-line?
A) Methimazole
B) Levothyroxine
C) Radioactive iodine
D) Propranolol
Rationale: Levothyroxine is the standard treatment for primary hypothyroidism; dose is
titrated to normalize TSH.
,3. A 55-year-old male with COPD presents with increased dyspnea and purulent
sputum. Which action is most appropriate?
A) Increase oxygen to 6 L/min
B) Prescribe antibiotics
C) Start high-dose inhaled corticosteroids
D) Order chest X-ray only
Rationale: Purulent sputum in COPD indicates bacterial exacerbation; antibiotics are
indicated along with bronchodilators.
4. A 28-year-old female at 10 weeks gestation reports severe nausea and vomiting.
Which medication is first-line?
A) Ondansetron
B) Doxylamine-pyridoxine
C) Metoclopramide
D) Promethazine
Rationale: Doxylamine-pyridoxine is first-line for nausea and vomiting of pregnancy per
ACOG guidelines.
5. A 70-year-old male presents with sudden painless vision loss in one eye. Which
condition should the FNP suspect?
A) Glaucoma
B) Central retinal artery occlusion
C) Cataracts
D) Macular degeneration
Rationale: Sudden painless vision loss suggests central retinal artery occlusion; an
ophthalmologic emergency.
,6. A 50-year-old female has a fasting glucose of 118 mg/dL. Which diagnosis is
correct?
A) Normal
B) Pre-diabetes
C) Diabetes mellitus
D) Hypoglycemia
Rationale: Fasting glucose 100–125 mg/dL indicates pre-diabetes; lifestyle modification is
first-line.
7. A 35-year-old male presents with urethral discharge and dysuria. Which
organism is most likely?
A) E. coli
B) Chlamydia trachomatis
C) Staphylococcus aureus
D) Candida albicans
Rationale: Chlamydia is a common cause of urethritis in young males; treat with
azithromycin or doxycycline.
8. A 65-year-old female has a BMI of 32. Which classification is correct?
A) Normal weight
B) Overweight
C) Obesity class I
D) Obesity class II
Rationale: BMI 30–34.9 is classified as obesity class I.
9. A 40-year-old male presents with episodic headaches, palpitations, and
diaphoresis. Which condition should the FNP suspect?
A) Anxiety
B) Pheochromocytoma
, C) Hyperthyroidism
D) Carcinoid syndrome
Rationale: Episodic headaches, palpitations, and diaphoresis suggest pheochromocytoma;
check plasma metanephrines.
10. A 55-year-old female has a new diagnosis of hypothyroidism. Which lab
finding is expected?
A) Low TSH, high T4
B) High TSH, low T4
C) High TSH, high T4
D) Low TSH, low T4
Rationale: Primary hypothyroidism causes elevated TSH and low free T4.
11. A 60-year-old male presents with resting tremor, rigidity, and bradykinesia.
Which diagnosis is correct?
A) Essential tremor
B) Parkinson's disease
C) Multiple sclerosis
D) Huntington's disease
Rationale: Resting tremor, rigidity, and bradykinesia are classic for Parkinson's disease;
treat with levodopa-carbidopa.
12. A 25-year-old female presents with malar rash and photosensitivity. Which
condition should the FNP suspect?
A) Rosacea
B) Systemic lupus erythematosus
C) Dermatomyositis
D) Psoriasis
