1
HESI A2 Entrance Exam Verified Questions and
Correct Answers A+ Graded Actual Exam
2026/2027 Complete Exam-Style Questions with
Detailed Rationales | 100% Verified | Pass
Guaranteed – A+ Graded
Part I: Mathematics, Reading Comprehension & Vocabulary
(Questions 1-15)
Q1: A nurse needs to administer 250 mg of a medication. The
available medication comes in a concentration of 125 mg/5 mL.
How many milliliters should the nurse give?
A. 8 mL
B. 10 mL
C. 12 mL [CORRECT]
D. 15 mL
Correct Answer: B
Rationale: The best answer is 10 mL because you set up the
proportion: 250 mg / x mL = 125 mg / 5 mL. Cross-multiplying
gives you 125x = 1,250, so x = 10 mL. This is a classic dosage
calculation that shows up frequently on the HESI A2.
,2
Q2: Read the following passage and answer the question:
The integumentary system serves as the body's first line of
defense against pathogens. The skin, which is the largest organ,
contains multiple layers that work together to protect underlying
tissues. The epidermis provides a waterproof barrier, while the
dermis contains blood vessels, nerve endings, and glands. When
the skin is compromised, the risk of infection increases
significantly.
What is the main idea of this passage?
A. The skin has exactly three distinct layers with no interaction
between them
B. The integumentary system protects the body through its
structural components [CORRECT]
C. Infections only occur when the dermis is damaged
D. Nerve endings are the most important part of the skin
Correct Answer: B
Rationale: This choice is correct because the passage focuses on
how the integumentary system (primarily the skin) functions as
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a protective barrier for the body, describing the roles of different
layers. The other options either misstate information from the
passage or focus on minor details rather than the central theme.
Q3: Which word means "the process of forming urine"?
A. Hematopoiesis
B. Glycolysis
C. Urination
D. Uropoiesis [CORRECT]
Correct Answer: D
Rationale: The best answer is uropoiesis because the prefix "uro-
" relates to urine and the suffix "-poiesis" refers to the formation
or production of something. This follows standard medical
terminology construction that appears regularly on HESI
vocabulary questions.
Q4: Convert 0.375 to a percentage.
A. 3.75%
B. 37.5% [CORRECT]
, 4
C. 0.375%
D. 375%
Correct Answer: B
Rationale: This choice is correct because to convert a decimal to
a percentage, you multiply by 100. So 0.375 × 100 = 37.5%.
This is a fundamental conversion skill tested on the mathematics
portion of the HESI A2.
Q5: In the context of healthcare communication, what does the
word "efficacious" most nearly mean?
A. Difficult to understand
B. Producing the intended effect [CORRECT]
C. Related to facial features
D. Causing harm or injury
Correct Answer: B
Rationale: The best answer is "producing the intended effect"
because efficacious describes something (often a treatment or
intervention) that is capable of producing the desired result.
HESI A2 Entrance Exam Verified Questions and
Correct Answers A+ Graded Actual Exam
2026/2027 Complete Exam-Style Questions with
Detailed Rationales | 100% Verified | Pass
Guaranteed – A+ Graded
Part I: Mathematics, Reading Comprehension & Vocabulary
(Questions 1-15)
Q1: A nurse needs to administer 250 mg of a medication. The
available medication comes in a concentration of 125 mg/5 mL.
How many milliliters should the nurse give?
A. 8 mL
B. 10 mL
C. 12 mL [CORRECT]
D. 15 mL
Correct Answer: B
Rationale: The best answer is 10 mL because you set up the
proportion: 250 mg / x mL = 125 mg / 5 mL. Cross-multiplying
gives you 125x = 1,250, so x = 10 mL. This is a classic dosage
calculation that shows up frequently on the HESI A2.
,2
Q2: Read the following passage and answer the question:
The integumentary system serves as the body's first line of
defense against pathogens. The skin, which is the largest organ,
contains multiple layers that work together to protect underlying
tissues. The epidermis provides a waterproof barrier, while the
dermis contains blood vessels, nerve endings, and glands. When
the skin is compromised, the risk of infection increases
significantly.
What is the main idea of this passage?
A. The skin has exactly three distinct layers with no interaction
between them
B. The integumentary system protects the body through its
structural components [CORRECT]
C. Infections only occur when the dermis is damaged
D. Nerve endings are the most important part of the skin
Correct Answer: B
Rationale: This choice is correct because the passage focuses on
how the integumentary system (primarily the skin) functions as
,3
a protective barrier for the body, describing the roles of different
layers. The other options either misstate information from the
passage or focus on minor details rather than the central theme.
Q3: Which word means "the process of forming urine"?
A. Hematopoiesis
B. Glycolysis
C. Urination
D. Uropoiesis [CORRECT]
Correct Answer: D
Rationale: The best answer is uropoiesis because the prefix "uro-
" relates to urine and the suffix "-poiesis" refers to the formation
or production of something. This follows standard medical
terminology construction that appears regularly on HESI
vocabulary questions.
Q4: Convert 0.375 to a percentage.
A. 3.75%
B. 37.5% [CORRECT]
, 4
C. 0.375%
D. 375%
Correct Answer: B
Rationale: This choice is correct because to convert a decimal to
a percentage, you multiply by 100. So 0.375 × 100 = 37.5%.
This is a fundamental conversion skill tested on the mathematics
portion of the HESI A2.
Q5: In the context of healthcare communication, what does the
word "efficacious" most nearly mean?
A. Difficult to understand
B. Producing the intended effect [CORRECT]
C. Related to facial features
D. Causing harm or injury
Correct Answer: B
Rationale: The best answer is "producing the intended effect"
because efficacious describes something (often a treatment or
intervention) that is capable of producing the desired result.
