COMLEX LEVEL 1 COMPREHENSIVE
QUESTIONS AND CORRECT ANSWERS
◉ MOA + Use: Oxandrolone.
Answer: MOA: Anabolic-Androgenic steroid
Use: Treatment of severe burns
ADE: Testicular atrophy
◉ MOA: Sirolimus.
Answer: mTOR inhibitor
-binds FKBP to inhibit mTOR
inhibits proliferation of T cells in response to IL2
◉ MOA of tacrolimus.
Answer: Calcineurin inhibitor via binding with intracellular FKBP-12
protein which
impairs IL-2
,use: transplant rejection
◉ MOA: Danazol.
Answer: Synthetic steroid
Decreases production of LH and FSH
◉ What is the most common cause of death in patients with
Polycystic Kidney Disease?.
Answer: Cardiac disease
◉ Elevation of which hormone can confirm menopause in women of
appropriate age?.
Answer: FSH
◉ What are the positive immunohistochemical stains for
leiomyosarcoma?.
Answer: Desmin
Vimentin
H-Caldesmon
Actin
◉ Which renal pathology is associated with Broad, waxy casts?.
,Answer: Advanced Chronic renal failure
◉ What drug is commonly used for Neuropathic pain?.
Answer: Amitriptyline (TCA)
ADE of note: strong muscarinic blocking properties = urinary
retention and tachycardia
◉ Location of high risk HPV strain infections.
Answer: basal layer of the squamous epithelium of the ectocervix
◉ MOA of acyclovir.
Answer: Competitively inhibits DNA polymerase, chain termination
occurs
tx for genital herpes
◉ Describe histological appearance of leydig cell tumor.
Answer: large polygonal cells with vacuolated cytoplasm and Reinke
Crystals (found in the interstitum of the testes) = rod shaped
intracytoplasmic crystal inclusions with rounded ends
◉ What is the first line treatment for gonorrhea?.
, Answer: Ceftriaxone
** remember to treat for this and chlamydia ( add azithromycin or
doxycycline)
◉ Where do you see Anti--microsomal antibodies?.
Answer: Hashimoto's thyroiditis
◉ What are the signs and symptoms associated with Paget's disease
of the breast?.
Answer: crusting, eczema like reaction, fissures around the areola
associated with an invasive DUCTAL carcinoma
◉ MOA of tamoxifen?.
Answer: Antagonist at breast
agonist at bone, uterus
ADE: increased risk thromboembolic events (esp with smoking) and
endometrial cancer
◉ leiomyoma.
QUESTIONS AND CORRECT ANSWERS
◉ MOA + Use: Oxandrolone.
Answer: MOA: Anabolic-Androgenic steroid
Use: Treatment of severe burns
ADE: Testicular atrophy
◉ MOA: Sirolimus.
Answer: mTOR inhibitor
-binds FKBP to inhibit mTOR
inhibits proliferation of T cells in response to IL2
◉ MOA of tacrolimus.
Answer: Calcineurin inhibitor via binding with intracellular FKBP-12
protein which
impairs IL-2
,use: transplant rejection
◉ MOA: Danazol.
Answer: Synthetic steroid
Decreases production of LH and FSH
◉ What is the most common cause of death in patients with
Polycystic Kidney Disease?.
Answer: Cardiac disease
◉ Elevation of which hormone can confirm menopause in women of
appropriate age?.
Answer: FSH
◉ What are the positive immunohistochemical stains for
leiomyosarcoma?.
Answer: Desmin
Vimentin
H-Caldesmon
Actin
◉ Which renal pathology is associated with Broad, waxy casts?.
,Answer: Advanced Chronic renal failure
◉ What drug is commonly used for Neuropathic pain?.
Answer: Amitriptyline (TCA)
ADE of note: strong muscarinic blocking properties = urinary
retention and tachycardia
◉ Location of high risk HPV strain infections.
Answer: basal layer of the squamous epithelium of the ectocervix
◉ MOA of acyclovir.
Answer: Competitively inhibits DNA polymerase, chain termination
occurs
tx for genital herpes
◉ Describe histological appearance of leydig cell tumor.
Answer: large polygonal cells with vacuolated cytoplasm and Reinke
Crystals (found in the interstitum of the testes) = rod shaped
intracytoplasmic crystal inclusions with rounded ends
◉ What is the first line treatment for gonorrhea?.
, Answer: Ceftriaxone
** remember to treat for this and chlamydia ( add azithromycin or
doxycycline)
◉ Where do you see Anti--microsomal antibodies?.
Answer: Hashimoto's thyroiditis
◉ What are the signs and symptoms associated with Paget's disease
of the breast?.
Answer: crusting, eczema like reaction, fissures around the areola
associated with an invasive DUCTAL carcinoma
◉ MOA of tamoxifen?.
Answer: Antagonist at breast
agonist at bone, uterus
ADE: increased risk thromboembolic events (esp with smoking) and
endometrial cancer
◉ leiomyoma.
