COMLEX LEVEL 1 COMPLETE STUDY GUIDE
WITH SOLVED QUESTIONS
◉ What is the treatment of Toxoplasma gondii.
Answer: Pyrimethamine + sulfadiazine
Prophylactic at CD4 < 100: TMP-SMX
◉ sleep spindles and K complexes.
Answer: stage 2 sleep
◉ What stage of sleep occupies the most time.
Answer: Stage 2 (60%)
Stage 1 (50%)
REM (20-25%)
◉ What stage of sleep is associated with slow wave sleep and delta
waves.
Answer: stage 3 and 4
,◉ Describe Persistent Depressive Disorder (Dysthymia).
Answer: >2 depression symptoms lasting >2 years without no more
than 2 months without depressive symptoms
(no periods of hypomania or feeling better [cyclothymic disorder])
◉ What are the lab findings associated with viral meningitis?
Opening Pressure
WBC
Glucose
Protein.
Answer: Opening Pressure: Normal (<180)
WBC: increased slightly (>50% lymphocytes)
Glucose: normal
Protein: Variable
◉ Lab findings: Bacterial Meningitis
,Opening Pressure
WBC
Glucose
Protein.
Answer: Opening Pressure: slightly increased (200-500)
WBC: increased (80% PMNs)
Glucose: decreased
Protein: slightly increased
◉ Lab findings: Fungal Meningitis
Opening Pressure
WBC
Glucose
Protein.
Answer: Opening Pressure: increased
, WBC: increased (>50% lymphocytes)
Glucose: normal to increased
Protein: increased
◉ MOA: Zolpidem.
Answer: positive allosteric modulator of the omega-1 type GABA
receptors, resulting in increased chloride conductance, neuronal
hyperpolarization, inhibition of action potential, and a decrease in
neuronal excitability that in turn produces sedative and hypnotic
effects
◉ Use of Zolpidem, Zaleplon and Eszopicone.
Answer: newer hypnotics that are less likely to change sleep
patterns, exhibit minimal daytime sedation, and have a low
tolerance profile when compared to benzodiazepines.
◉ Define: Leaden Paralysis.
Answer: Heavy feeling in arms or legs
seen in depressive disorder with atypical features
◉ what is the time course associated with a diagnosis of
schizophreniform disorder?.
WITH SOLVED QUESTIONS
◉ What is the treatment of Toxoplasma gondii.
Answer: Pyrimethamine + sulfadiazine
Prophylactic at CD4 < 100: TMP-SMX
◉ sleep spindles and K complexes.
Answer: stage 2 sleep
◉ What stage of sleep occupies the most time.
Answer: Stage 2 (60%)
Stage 1 (50%)
REM (20-25%)
◉ What stage of sleep is associated with slow wave sleep and delta
waves.
Answer: stage 3 and 4
,◉ Describe Persistent Depressive Disorder (Dysthymia).
Answer: >2 depression symptoms lasting >2 years without no more
than 2 months without depressive symptoms
(no periods of hypomania or feeling better [cyclothymic disorder])
◉ What are the lab findings associated with viral meningitis?
Opening Pressure
WBC
Glucose
Protein.
Answer: Opening Pressure: Normal (<180)
WBC: increased slightly (>50% lymphocytes)
Glucose: normal
Protein: Variable
◉ Lab findings: Bacterial Meningitis
,Opening Pressure
WBC
Glucose
Protein.
Answer: Opening Pressure: slightly increased (200-500)
WBC: increased (80% PMNs)
Glucose: decreased
Protein: slightly increased
◉ Lab findings: Fungal Meningitis
Opening Pressure
WBC
Glucose
Protein.
Answer: Opening Pressure: increased
, WBC: increased (>50% lymphocytes)
Glucose: normal to increased
Protein: increased
◉ MOA: Zolpidem.
Answer: positive allosteric modulator of the omega-1 type GABA
receptors, resulting in increased chloride conductance, neuronal
hyperpolarization, inhibition of action potential, and a decrease in
neuronal excitability that in turn produces sedative and hypnotic
effects
◉ Use of Zolpidem, Zaleplon and Eszopicone.
Answer: newer hypnotics that are less likely to change sleep
patterns, exhibit minimal daytime sedation, and have a low
tolerance profile when compared to benzodiazepines.
◉ Define: Leaden Paralysis.
Answer: Heavy feeling in arms or legs
seen in depressive disorder with atypical features
◉ what is the time course associated with a diagnosis of
schizophreniform disorder?.
