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COMLEX Level 2-CE Test Bank | Q&A Study Guide

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Prepare for COMLEX Level 2-CE with verified questions on clinical medicine, OMM, and high-yield topics. 320-question format study guide for .

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Test bank for COMLEX LEVEL 2 EXAM
latest updates!!! 2026-2027 |
correct solutions WITH QUESTIONS
AND ANSWERS | highly graded a+

____ ____ is an antifibrinolytic medication that should be administered to patients who
have moderate TBI (GCS 9-12). For prevention of ___ ___. - CORRECT ANSWERS-1.
Tranexamic acid
2. intracranial hemorrhage

Congenital syphilis: baby presents with - CORRECT ANSWERS-o Clear rhinorrhea
o Maculopapular rash on the feet and buttocks that later desquamates

Inferior wall myocardial infarction: ST segment elevations in ___, ___ and ___ -
CORRECT ANSWERS-II, III and aVF

Mitral regurgitation: III/VI early ___ murmur at the cardiac ____ - CORRECT
ANSWERS-1. systolic
2. apex

Pulmonary edema: Bibasilar ___ - CORRECT ANSWERS-crackles

In a woman with PCOS that is trying to conceive, give ___ (an aromatase inhibitor that
inhibits the conversion of androgens to estrogens) - CORRECT ANSWERS-letrozole

Interstitial nephritis: Most frequently occurs as a ___ reaction. Fever, rash, acute kidney
injury and ___ with ___ blood cell casts - CORRECT ANSWERS-1. drug
2. eosinophiluria
3. white

Raynaud phenomenon treatment - CORRECT ANSWERS-dihydropyridine calcium
channel blockers (nifedipine, amlodipine)

Atomoxetine: ____ reuptake inhibitor. For ___ ADHD for someone who does not want to
take something addictive - CORRECT ANSWERS-1. Norepinephrine
2. adult

,Clonidine, guanfacine: Treats ADHD in ____ but NOT ____ - CORRECT ANSWERS-1.
children
2. adults

Ventricular septal defect: 1/6 ____ over the left lower sternal (or midsternal) border with
a ____ rumble over the cardiac apex - CORRECT ANSWERS-1. holosystolic
2. diastolic

Ventricular septal defect: what kind of shunting? - CORRECT ANSWERS-Left-to-right
shunting

Ventricular septal defect: prominent ___ - CORRECT ANSWERS-S2

Ventricular septal defect: ___ sided volume overload - CORRECT ANSWERS-left

Atrial septal defect: ___ valve flow murmur - CORRECT ANSWERS-pulmonic

Atrial septal defect: ____ sided volume overload - CORRECT ANSWERS-right

Atrial septal defect: Wide and fixed splitting of ___ - CORRECT ANSWERS-S2

Mitral stenosis results from ___ ___ - CORRECT ANSWERS-rheumatic fever

Tetralogy of Fallot: Harsh ____ ejection murmur at the left upper sternal border -
CORRECT ANSWERS-systolic

Cytomegalovirus infection: ____-like initial illness - CORRECT ANSWERS-
Mononucleosis

Cytomegalovirus infection: Fever, malaise, fatigue, absolute ____ - CORRECT
ANSWERS-lymphocytosis

Cytomegalovirus infection: Mild elevations in ____ levels - CORRECT ANSWERS-
aminotransferase

Cytomegalovirus infection: what population is most at risk? - CORRECT ANSWERS-
men who have sex with men

What are the four components of acute lymphoblastic leukemia? - CORRECT
ANSWERS-o Lymphadenopathy
o Anemia (fatigue)
o Thrombocytopenia (bruising)
o Neutropenia (infection)

What are two medications used for spasticity treatment? - CORRECT ANSWERS-
Baclofen (agonist at the GABA-B receptor) or tizanidine (alpha-2 adrenergic agonist)

,What are three medications used for fatigue treatment? - CORRECT ANSWERS-
Amantadine, methylphenidate, modafinil

What are two medications used for urge urinary incontinence treatment? - CORRECT
ANSWERS-Oxybutynin, tolterodine

What are three medications used for restless legs syndrome treatment? - CORRECT
ANSWERS-Primarily gabapentin, pregabalin but can also use pramipexole (dopamine
agonist)

Acute tubular necrosis: Renal tubular ____. ____ granular casts. Free renal tubular
____ cells. - CORRECT ANSWERS-1. obstruction
2. Muddy-brown
3. epithelial

Initial treatment of acute decompensated heart failure? - CORRECT ANSWERS-IV loop
diuretics (bumetanide) and/or milrinone

Ruptured or enlarging posterior communicating artery aneurysms can compress the ___
nerve causing ___ nerve palsy. - CORRECT ANSWERS-oculomotor

Anterior communicating artery aneurysms can compress the ___ __, causing __ __
___. - CORRECT ANSWERS-1. optic chiasm
2. bitemporal heteronymous hemianopsia

Hairy cell leukemia is a malignant disorder of well-differentiated ___ lymphocytes. It
typically presents with weakness, fatigue, anemia, thrombocytopenia, neutropenia and
palpable ____. - CORRECT ANSWERS-1. B
2. splenomegaly

What bug most frequently causes otitis externa? - CORRECT ANSWERS-
Pseudomonas aeruginosa

Pertussis:
o ___ and gasping for air
o Coughing harshly while feeding and then stopped ____
o Become ___
o Clear ___
o Increasing cough followed by episodes of ___
o Referred ___ airway congestion
o Treat with ___ - CORRECT ANSWERS-1. Gagging
2. breathing
3. cyanotic
4. rhinorrhea
5. emesis

, 6. upper
7. macrolide (azithromycin)

Bipolar I disorder treatment? - CORRECT ANSWERS-lithium or valproate combined
with a second-generation antipsychotic (quetiapine) is first line

What type of medication is haloperidol? - CORRECT ANSWERS-first generation
antipsychotic

Acute anteroseptal infarct
o ST elevation in leads ___-___
o ST depression in leads ___, ___ and ___ - CORRECT ANSWERS-1. V1-V3
2. II, III and aVF

What is a complication of cardiac catheterization? - CORRECT ANSWERS-
Embolization of a cholesterol plaque

Anal fissures can be treated with? - CORRECT ANSWERS-topical nitroglycerin

Innominate rotation occurs around the ____ transverse axis of the sacrum - CORRECT
ANSWERS-inferior

Lithium causes what two electrolyte abnormalities? - CORRECT ANSWERS-
hypercalcemia and hypernatremia

Gaucher disease
o What three symptoms?
o Neutropenia, thrombocytopenia or both?
o Enzyme deficiency? - CORRECT ANSWERS-1. Easy bruising, Bone pain,
Splenomegaly
2. Both
3. glucocerebrosidase

Ventricular septal defect: what is the work-up? - CORRECT ANSWERS-ECG and
echocardiography

Thrombotic thrombocytopenic purpura (TTP):
-Presents with encephalopathy, fever, ___, thrombocytopenia, and ___ ___.
-What is seen on peripheral blood smear?
-What is deficient? - CORRECT ANSWERS-1. anemia
2. renal insufficiency
3. schistocytes
4. ADAMTS13, also known as von Willebrand factor-cleaving protease

Budd-Chiari syndrome:
-___ venous outflow obstruction

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