Name ________________________________ Date _____________
BIOL 102 Exam 2 Practice
There are 25 MCQs covering: Cancer, Stem Cells, and Cardiovascular (Parts 1 and 2). Please also visit here
for more resources: tinyurl.com/exam2resources
1. A _______ cell in a basic growth medium will _______ .
a. normal; require signaling molecules from external factors to proliferate
b. normal; only stop dividing if given signals from other cells
c. cancer; exhibit anchorage dependence
d. cancer; exhibit density-dependent inhibition
e. There is more than one correct answer.
2. A proto-oncogene can become an oncogene when it undergoes ___, but not when it undergoes
___.
a. amplification ; a point mutation that makes its protein hyperactive
b. a promoter translocation ; increased transcription
c. a recombination event ; a deletion that eliminates its coding region
d. replication error producing extra copies ; a translocation that joins it to an active
promoter
e. none of the above
3. Which of the following statements about tumor suppressor genes is correct?
a. Tumor suppressor genes may be transcriptionally upregulated or their proteins stabilized
in response to DNA damage or failure to meet cell-cycle checkpoints.
b. Tumor suppressor genes are only inactivated by mutations in the genes themselves or in
their regulators.
c. Tumor suppressor genes function exclusively at the G1 → S and S →G2 transitions.
d. In most cases, two mutations are required to fully activate a tumor suppressor gene.
e. More than one of the above is correct.
, 4. Which of the following statements correctly describes a difference between healthy cells and
cancer cells when they are grown in a basic growth medium?
a. All healthy cells require external signaling molecules to divide efficiently, whereas all
cancer cells can divide efficiently without them.
b. All healthy cells stop dividing because of density-dependent inhibition, whereas all
cancer cells continue dividing regardless of cell density.
c. Healthy cells are easier to grow in a basic growth medium than cancer cells.
d. Once healthy cells form a monolayer, they stop dividing, but cancer cells may continue to
divide after a monolayer has formed.
e. More than one of the above is correct.
5. A cell is observed to have a reduced amount of normal tumor suppressor proteins. Which of the
following is least likely to have caused this?
a. A point mutation in a promoter or other control region
b. A point mutation within the coding region of the gene
c. Deletion of the gene from the chromosome
d. A translocation that moves the gene next to a non-functional promoter
e. A viral infection
6. A cell with a Philadelphia chromosome mutation would likely experience all of the following
except:
a. Increased activity of GTP-binding proteins
b. Increased activity of protein kinases
c. Increased activity of transcription factors
d. Increased activity of primary messengers
e. There are no exceptions above.
7. Which of the following statements about p53 tumor suppressor is false?
a. p53 gets stabilized and degraded by MDM2 as a negative regulator.
b. p53 is a transcription factor for cell regulatory genes and DNA repair genes.
c. p53 can be activated by signals such as telomere shortening and hypoxia.
d. p53 can act as a competitive inhibitor on CDK, preventing binding of cyclins.
e. There is more than one false statement above.
BIOL 102 Exam 2 Practice
There are 25 MCQs covering: Cancer, Stem Cells, and Cardiovascular (Parts 1 and 2). Please also visit here
for more resources: tinyurl.com/exam2resources
1. A _______ cell in a basic growth medium will _______ .
a. normal; require signaling molecules from external factors to proliferate
b. normal; only stop dividing if given signals from other cells
c. cancer; exhibit anchorage dependence
d. cancer; exhibit density-dependent inhibition
e. There is more than one correct answer.
2. A proto-oncogene can become an oncogene when it undergoes ___, but not when it undergoes
___.
a. amplification ; a point mutation that makes its protein hyperactive
b. a promoter translocation ; increased transcription
c. a recombination event ; a deletion that eliminates its coding region
d. replication error producing extra copies ; a translocation that joins it to an active
promoter
e. none of the above
3. Which of the following statements about tumor suppressor genes is correct?
a. Tumor suppressor genes may be transcriptionally upregulated or their proteins stabilized
in response to DNA damage or failure to meet cell-cycle checkpoints.
b. Tumor suppressor genes are only inactivated by mutations in the genes themselves or in
their regulators.
c. Tumor suppressor genes function exclusively at the G1 → S and S →G2 transitions.
d. In most cases, two mutations are required to fully activate a tumor suppressor gene.
e. More than one of the above is correct.
, 4. Which of the following statements correctly describes a difference between healthy cells and
cancer cells when they are grown in a basic growth medium?
a. All healthy cells require external signaling molecules to divide efficiently, whereas all
cancer cells can divide efficiently without them.
b. All healthy cells stop dividing because of density-dependent inhibition, whereas all
cancer cells continue dividing regardless of cell density.
c. Healthy cells are easier to grow in a basic growth medium than cancer cells.
d. Once healthy cells form a monolayer, they stop dividing, but cancer cells may continue to
divide after a monolayer has formed.
e. More than one of the above is correct.
5. A cell is observed to have a reduced amount of normal tumor suppressor proteins. Which of the
following is least likely to have caused this?
a. A point mutation in a promoter or other control region
b. A point mutation within the coding region of the gene
c. Deletion of the gene from the chromosome
d. A translocation that moves the gene next to a non-functional promoter
e. A viral infection
6. A cell with a Philadelphia chromosome mutation would likely experience all of the following
except:
a. Increased activity of GTP-binding proteins
b. Increased activity of protein kinases
c. Increased activity of transcription factors
d. Increased activity of primary messengers
e. There are no exceptions above.
7. Which of the following statements about p53 tumor suppressor is false?
a. p53 gets stabilized and degraded by MDM2 as a negative regulator.
b. p53 is a transcription factor for cell regulatory genes and DNA repair genes.
c. p53 can be activated by signals such as telomere shortening and hypoxia.
d. p53 can act as a competitive inhibitor on CDK, preventing binding of cyclins.
e. There is more than one false statement above.
