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What can Reactive Oxygen Species cause?
Heart disease, Alzheimers, Parkinsons, Amyotrophic Lateral Sclerosis (ALS), CV disease,
HTN, HLD, DM, ischemic heart disease, HF, OSA. Lipid perioxidation, damage proteins,
fragment DNA, less protein synthesis, chromatin destruction, damage mitochondria
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How are free radicals produced?
1. Normal cellular respiration
2. Absorption of extreme energy sources (radiation, UV light)
3. Metabolism of exogenous chemicals, drugs, and pesticides
4. Transition of metals
5. Nitric oxide acting like a chemical mediator and a free radical
What is the body's defense against ROS?
Antioxidants (Vitamin E, Vitamin C, cysteine, glutathione, albumin, ceruloplasmin, transferrin)
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action potential
Process of conducting an impulse. Activates the neuron --> the neuron depolarizes --> then
repolarizes
Threshold potential
Point at which depolarization must reach in order to initiate an action potential
Hypokalemia and action potentials
HYPERpolarized (more negative, ex. -100). Less excitable. Decreased neuromuscular
excitability: weakness, smooth muscle atony, paresthesia, cardiac dysrhythmias
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