ATI RN Targeted Medical-
Surgical Immune Practice
Exam 2026–2027| Complete
Test Prep Practice Questions
With Answers & Detailed
Rationales |clinical Judgment
&Safety |A+ Rated
1.
A nurse is assessing a client who has systemic lupus erythematosus
(SLE). Which finding should the nurse expect?
A. Unilateral calf swelling
B. Butterfly-shaped facial rash
C. Productive cough with purulent sputum
D. Increased urine output
Answer: B. Butterfly-shaped facial rash
The malar or “butterfly” rash across the cheeks and bridge of the
nose is a classic manifestation of SLE.
2.
,A nurse is teaching a client who has SLE about avoiding
exacerbations. Which instruction should the nurse include?
A. Increase exposure to sunlight
B. Avoid foods containing calcium
C. Use sunscreen when outdoors
D. Restrict fluid intake
Answer: C. Use sunscreen when outdoors
Ultraviolet light can trigger or worsen SLE manifestations, so clients
should use protective clothing and sunscreen.
3.
A client with rheumatoid arthritis (RA) reports morning stiffness.
Which intervention should the nurse recommend?
A. Apply cold packs immediately after awakening
B. Take a warm shower in the morning
C. Remain on bed rest until stiffness resolves
D. Avoid physical activity throughout the day
Answer: B. Take a warm shower in the morning
Warmth helps decrease joint stiffness and improves mobility,
particularly after periods of inactivity.
4.
Which finding is most characteristic of rheumatoid arthritis?
A. Symmetrical joint inflammation
B. Unilateral ankle edema
C. Painless joint enlargement only
D. Absence of systemic manifestations
,Answer: A. Symmetrical joint inflammation
RA commonly affects joints symmetrically and can produce systemic
manifestations.
5.
A nurse is caring for a client who has RA and is prescribed
methotrexate. Which laboratory test is most important to monitor?
A. Serum sodium
B. Liver function tests
C. Serum amylase
D. Troponin level
Answer: B. Liver function tests
Methotrexate can cause hepatotoxicity, so liver function should be
monitored.
6.
A client taking methotrexate for RA should report which finding
immediately?
A. Mild thirst
B. Hair growth
C. Fever and sore throat
D. Increased appetite
Answer: C. Fever and sore throat
Methotrexate suppresses bone marrow and immune function,
increasing the risk for infection.
7.
, A nurse is teaching a client about hydroxychloroquine therapy for
SLE. Which assessment is important?
A. Hearing examination
B. Eye examination
C. Pulmonary function testing
D. Bone density every week
Answer: B. Eye examination
Hydroxychloroquine can cause retinal toxicity; regular
ophthalmologic examinations are required.
8.
A nurse is caring for a client with SLE who has photosensitivity.
Which action is appropriate?
A. Encourage tanning to increase vitamin D
B. Recommend protective clothing outdoors
C. Encourage prolonged afternoon sunlight
D. Use tanning beds during winter
Answer: B. Recommend protective clothing outdoors
UV exposure can precipitate SLE flares.
9.
A client with SLE has proteinuria and edema. The nurse should
suspect which complication?
A. Renal involvement
B. Otitis media
C. Cataracts
D. Appendicitis
Surgical Immune Practice
Exam 2026–2027| Complete
Test Prep Practice Questions
With Answers & Detailed
Rationales |clinical Judgment
&Safety |A+ Rated
1.
A nurse is assessing a client who has systemic lupus erythematosus
(SLE). Which finding should the nurse expect?
A. Unilateral calf swelling
B. Butterfly-shaped facial rash
C. Productive cough with purulent sputum
D. Increased urine output
Answer: B. Butterfly-shaped facial rash
The malar or “butterfly” rash across the cheeks and bridge of the
nose is a classic manifestation of SLE.
2.
,A nurse is teaching a client who has SLE about avoiding
exacerbations. Which instruction should the nurse include?
A. Increase exposure to sunlight
B. Avoid foods containing calcium
C. Use sunscreen when outdoors
D. Restrict fluid intake
Answer: C. Use sunscreen when outdoors
Ultraviolet light can trigger or worsen SLE manifestations, so clients
should use protective clothing and sunscreen.
3.
A client with rheumatoid arthritis (RA) reports morning stiffness.
Which intervention should the nurse recommend?
A. Apply cold packs immediately after awakening
B. Take a warm shower in the morning
C. Remain on bed rest until stiffness resolves
D. Avoid physical activity throughout the day
Answer: B. Take a warm shower in the morning
Warmth helps decrease joint stiffness and improves mobility,
particularly after periods of inactivity.
4.
Which finding is most characteristic of rheumatoid arthritis?
A. Symmetrical joint inflammation
B. Unilateral ankle edema
C. Painless joint enlargement only
D. Absence of systemic manifestations
,Answer: A. Symmetrical joint inflammation
RA commonly affects joints symmetrically and can produce systemic
manifestations.
5.
A nurse is caring for a client who has RA and is prescribed
methotrexate. Which laboratory test is most important to monitor?
A. Serum sodium
B. Liver function tests
C. Serum amylase
D. Troponin level
Answer: B. Liver function tests
Methotrexate can cause hepatotoxicity, so liver function should be
monitored.
6.
A client taking methotrexate for RA should report which finding
immediately?
A. Mild thirst
B. Hair growth
C. Fever and sore throat
D. Increased appetite
Answer: C. Fever and sore throat
Methotrexate suppresses bone marrow and immune function,
increasing the risk for infection.
7.
, A nurse is teaching a client about hydroxychloroquine therapy for
SLE. Which assessment is important?
A. Hearing examination
B. Eye examination
C. Pulmonary function testing
D. Bone density every week
Answer: B. Eye examination
Hydroxychloroquine can cause retinal toxicity; regular
ophthalmologic examinations are required.
8.
A nurse is caring for a client with SLE who has photosensitivity.
Which action is appropriate?
A. Encourage tanning to increase vitamin D
B. Recommend protective clothing outdoors
C. Encourage prolonged afternoon sunlight
D. Use tanning beds during winter
Answer: B. Recommend protective clothing outdoors
UV exposure can precipitate SLE flares.
9.
A client with SLE has proteinuria and edema. The nurse should
suspect which complication?
A. Renal involvement
B. Otitis media
C. Cataracts
D. Appendicitis
