NUR 600 ADVANCED CLINICAL PHARMACOLOGY
EXAM 1 2026 ST. THOMAS UNIVERSITY GRADED A
ACCURATE FALL SEMESTER QUESTIONS
Azithromycin dosing requires the first day's dose be twice those of the other 4
days of the prescription. This is considered a loading dose. A loading dose: A.
Rapidly achieves drug levels in the therapeutic range
B. Requires four to five half-lives to attain
C. Is influenced by renal function
D. Is directly related to the drug circulating to the target tissues
A. Rapidly achieves drug levels in the therapeutic range
The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effect is the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range
C. Onset of action
Phenytoin requires a trough level be drawn. Peak and trough levels are done: A.
When the drug has a wide therapeutic range
B. When the drug will be administered for a short time only
C. When there is a high correlation between the dose and saturation of receptor
sites
D. To determine if a drug is in the therapeutic range
D. To determine if a drug is in the therapeutic range
A laboratory result indicates the peak level for a drug is above the minimum toxic
concentration. This means that the:
A. Concentration will produce therapeutic effects
B. Concentration will produce an adverse response
C. Time between doses must be shortened
D. Duration of action of the drug is too long
,B. Concentration will produce an adverse response
Drugs that are receptor agonists may demonstrate what property?
A. Irreversible binding to the drug receptor site
B. Up-regulation with chronic use
C. Desensitization or down-regulation with continuous use
D. Inverse relationship between drug concentration and drug action
C. Desensitization or down-regulation with continuous use
Drugs that are receptor antagonists, such as beta blockers, may cause:
A. Down-regulation of the drug receptor
B. An exaggerated response if abruptly discontinued
C. Partial blockade of the effects of agonist drugs
D. An exaggerated response to competitive drug agonists
B. An exaggerated response if abruptly discontinued
Factors that affect gastric drug absorption include:
A. Liver enzyme activity
B. Protein-binding properties of the drug molecule
C. Lipid solubility of the drug
D. Ability to chew and swallow
C. Lipid solubility of the drug
Drugs administered via intravenous (IV) route:
A. Need to be lipid soluble in order to be easily absorbed
B. Begin distribution into the body immediately
C. Are easily absorbed if they are nonionized
D. May use pinocytosis to be absorbed
B. Begin distribution into the body immediately
When a medication is added to a regimen for a synergistic effect, the combined
effect of the drugs is:
A. The sum of the effects of each drug individually
B. Greater than the sum of the effects of each drug individually
C. Less than the effect of each drug individually
D. Not predictable, as it varies with each individual
,B. Greater than the sum of the effects of each drug individually
Which of the following statements about bioavailability is true?
A. Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained release mechanisms.
B. All brands of a drug have the same bioavailability.
C. Drugs that are administered more than once a day have greater bioavailability
than drugs given once daily.
D. Combining an active drug with an inert substance does not affect
A. Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained release mechanisms.
Which of the following statements about the major distribution barriers (blood
brain or fetal-placental) is true?
A. Water soluble and ionized drugs cross these barriers rapidly.
B. The blood-brain barrier slows the entry of many drugs into and from brain cells.
C. The fetal-placental barrier protects the fetus from drugs taken by the mother.
D. Lipid soluble drugs do not pass these barriers and are safe for pregnant women
B. The blood-brain barrier slows the entry of many drugs into and from brain cells.
Drugs are metabolized mainly by the liver via Phase I or Phase II reactions. The
purpose of both of these types of reactions is to:
A. Inactivate prodrugs before they can be activated by target tissues
B. Change the drugs so they can cross plasma membranes
C. Change drug molecules to a form that an excretory organ can excrete
D. Make these drugs more ionized and polar to facilitate excretion
C. Change drug molecules to a form that an excretory organ can excrete
Once they have been metabolized by the liver, the metabolites may be:
A. More active than the parent drug
B. Less active than the parent drug
C. Totally "deactivated" so that they are excreted without any effect
D. All of the above
D. All of the above
All drugs continue to act in the body until they are changed or excreted. The ability
of the body to excrete drugs via the renal system would be increased by:
A. Reduced circulation and perfusion of the kidney
B. Chronic renal disease
C. Competition for a transport site by another drug
D. Unbinding a nonvolatile drug from plasma proteins
, D. Unbinding a nonvolatile drug from plasma proteins
teady state is:
A. The point on the drug concentration curve when absorption exceeds excretion
B. When the amount of drug in the body remains constant
C. When the amount of drug in the body stays below the MTC
D. All of the above
B. When the amount of drug in the body remains constant
Two different pain meds are given together for pain relief. The drug-drug
interaction is:
A. Synergistic
B. Antagonistic
C. Potentiative
D. Additive
D. Additive
.Actions taken to reduce drug-drug interaction problems include all of the following
EXCEPT:
A. Reducing the dose of one of the drugs
B. Scheduling their administration at different times
C. Prescribing a third drug to counteract the adverse reaction of the combination
D. Reducing the dosage of both drugs
C. Prescribing a third drug to counteract the adverse reaction of the combination
Phase I oxidative-reductive processes of drug metabolism require certain
nutritional elements. Which of the following would reduce or inhibit this process?
A. Protein malnutrition
B. Iron deficiency anemia
C. Both A and B
D. Neither A nor B
D. Neither A nor B
The time required for the amount of drug in the body to decrease by 50% is called:
A. Steady state
B. Half-life
C. Phase II metabolism
D. Reduced bioavailability time
B. Half-life
EXAM 1 2026 ST. THOMAS UNIVERSITY GRADED A
ACCURATE FALL SEMESTER QUESTIONS
Azithromycin dosing requires the first day's dose be twice those of the other 4
days of the prescription. This is considered a loading dose. A loading dose: A.
Rapidly achieves drug levels in the therapeutic range
B. Requires four to five half-lives to attain
C. Is influenced by renal function
D. Is directly related to the drug circulating to the target tissues
A. Rapidly achieves drug levels in the therapeutic range
The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effect is the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range
C. Onset of action
Phenytoin requires a trough level be drawn. Peak and trough levels are done: A.
When the drug has a wide therapeutic range
B. When the drug will be administered for a short time only
C. When there is a high correlation between the dose and saturation of receptor
sites
D. To determine if a drug is in the therapeutic range
D. To determine if a drug is in the therapeutic range
A laboratory result indicates the peak level for a drug is above the minimum toxic
concentration. This means that the:
A. Concentration will produce therapeutic effects
B. Concentration will produce an adverse response
C. Time between doses must be shortened
D. Duration of action of the drug is too long
,B. Concentration will produce an adverse response
Drugs that are receptor agonists may demonstrate what property?
A. Irreversible binding to the drug receptor site
B. Up-regulation with chronic use
C. Desensitization or down-regulation with continuous use
D. Inverse relationship between drug concentration and drug action
C. Desensitization or down-regulation with continuous use
Drugs that are receptor antagonists, such as beta blockers, may cause:
A. Down-regulation of the drug receptor
B. An exaggerated response if abruptly discontinued
C. Partial blockade of the effects of agonist drugs
D. An exaggerated response to competitive drug agonists
B. An exaggerated response if abruptly discontinued
Factors that affect gastric drug absorption include:
A. Liver enzyme activity
B. Protein-binding properties of the drug molecule
C. Lipid solubility of the drug
D. Ability to chew and swallow
C. Lipid solubility of the drug
Drugs administered via intravenous (IV) route:
A. Need to be lipid soluble in order to be easily absorbed
B. Begin distribution into the body immediately
C. Are easily absorbed if they are nonionized
D. May use pinocytosis to be absorbed
B. Begin distribution into the body immediately
When a medication is added to a regimen for a synergistic effect, the combined
effect of the drugs is:
A. The sum of the effects of each drug individually
B. Greater than the sum of the effects of each drug individually
C. Less than the effect of each drug individually
D. Not predictable, as it varies with each individual
,B. Greater than the sum of the effects of each drug individually
Which of the following statements about bioavailability is true?
A. Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained release mechanisms.
B. All brands of a drug have the same bioavailability.
C. Drugs that are administered more than once a day have greater bioavailability
than drugs given once daily.
D. Combining an active drug with an inert substance does not affect
A. Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained release mechanisms.
Which of the following statements about the major distribution barriers (blood
brain or fetal-placental) is true?
A. Water soluble and ionized drugs cross these barriers rapidly.
B. The blood-brain barrier slows the entry of many drugs into and from brain cells.
C. The fetal-placental barrier protects the fetus from drugs taken by the mother.
D. Lipid soluble drugs do not pass these barriers and are safe for pregnant women
B. The blood-brain barrier slows the entry of many drugs into and from brain cells.
Drugs are metabolized mainly by the liver via Phase I or Phase II reactions. The
purpose of both of these types of reactions is to:
A. Inactivate prodrugs before they can be activated by target tissues
B. Change the drugs so they can cross plasma membranes
C. Change drug molecules to a form that an excretory organ can excrete
D. Make these drugs more ionized and polar to facilitate excretion
C. Change drug molecules to a form that an excretory organ can excrete
Once they have been metabolized by the liver, the metabolites may be:
A. More active than the parent drug
B. Less active than the parent drug
C. Totally "deactivated" so that they are excreted without any effect
D. All of the above
D. All of the above
All drugs continue to act in the body until they are changed or excreted. The ability
of the body to excrete drugs via the renal system would be increased by:
A. Reduced circulation and perfusion of the kidney
B. Chronic renal disease
C. Competition for a transport site by another drug
D. Unbinding a nonvolatile drug from plasma proteins
, D. Unbinding a nonvolatile drug from plasma proteins
teady state is:
A. The point on the drug concentration curve when absorption exceeds excretion
B. When the amount of drug in the body remains constant
C. When the amount of drug in the body stays below the MTC
D. All of the above
B. When the amount of drug in the body remains constant
Two different pain meds are given together for pain relief. The drug-drug
interaction is:
A. Synergistic
B. Antagonistic
C. Potentiative
D. Additive
D. Additive
.Actions taken to reduce drug-drug interaction problems include all of the following
EXCEPT:
A. Reducing the dose of one of the drugs
B. Scheduling their administration at different times
C. Prescribing a third drug to counteract the adverse reaction of the combination
D. Reducing the dosage of both drugs
C. Prescribing a third drug to counteract the adverse reaction of the combination
Phase I oxidative-reductive processes of drug metabolism require certain
nutritional elements. Which of the following would reduce or inhibit this process?
A. Protein malnutrition
B. Iron deficiency anemia
C. Both A and B
D. Neither A nor B
D. Neither A nor B
The time required for the amount of drug in the body to decrease by 50% is called:
A. Steady state
B. Half-life
C. Phase II metabolism
D. Reduced bioavailability time
B. Half-life
