ATI ALTERATIONS IN IMMUNITY AND
INFLAMMATORY FUNCTION UPDATED
ACTUAL QUESTIONS AND CORRECT
ANSWERS COMPREHENSIVE STUDY GUIDE
●● Hypersensitivity classifications
Answer: Allergy
Autoimmunity
Alloimmunity
●● Allergy
Answer: Produces deleterious effects of hypersensitivity to
environmental (exogenous) antigens
●● Autoimmunity
Answer: • Is a disturbance in immunologic tolerance of self-antigens.
• Can cause autoimmune diseases.
●● Alloimmunity
Answer: • Is an immune reaction to tissues of another individual
●● Hypersensitivity characterized by mechanism of disease
,Answer: based on what part of immune system is doing it
Type I, II, III, IV
●● Type I
Answer: IgE and mast cell mediated
eosinophils?
●● Type II
Answer: Tissue-specific reactions
●● Type III
Answer: immune complex mediated
●● Type IV
Answer: cell-mediated, delayed
●● Hypersensitivity NEVER OCCURS
Answer: during first exposure to antigen
●● Immediate hypersensitivity reactions
Answer: Occur minutes to hours after repeat antigenic exposure
, ●● Delayed hypersensitivity reactions
Answer: Take several hours to occur, maximum reaction seen days after
reexposure
●● Anaphylaxis
Answer: - occurs within minutes of re-exposure
- Severity depends on the level of sensitization
- Symptoms: rash, hives, throat swelling
●● Type I Hypersensitivity process (3 steps)
Answer: • Occurs against environmental antigens (allergens)
• IgE binds to crystalline fragment (Fc) receptors on the
surface of mast cells
• Leads to degranulation and histamine release
"IgE binding to mast cells in response to antigen.. leads to degranulation
of mast cells (histamine)*
●● Leads to degranulation and histamine release (type I)
Answer: -- H1 and H2 receptors
-- Chemotactic activity (draws more immune cells to area and create
more of a reaction)
INFLAMMATORY FUNCTION UPDATED
ACTUAL QUESTIONS AND CORRECT
ANSWERS COMPREHENSIVE STUDY GUIDE
●● Hypersensitivity classifications
Answer: Allergy
Autoimmunity
Alloimmunity
●● Allergy
Answer: Produces deleterious effects of hypersensitivity to
environmental (exogenous) antigens
●● Autoimmunity
Answer: • Is a disturbance in immunologic tolerance of self-antigens.
• Can cause autoimmune diseases.
●● Alloimmunity
Answer: • Is an immune reaction to tissues of another individual
●● Hypersensitivity characterized by mechanism of disease
,Answer: based on what part of immune system is doing it
Type I, II, III, IV
●● Type I
Answer: IgE and mast cell mediated
eosinophils?
●● Type II
Answer: Tissue-specific reactions
●● Type III
Answer: immune complex mediated
●● Type IV
Answer: cell-mediated, delayed
●● Hypersensitivity NEVER OCCURS
Answer: during first exposure to antigen
●● Immediate hypersensitivity reactions
Answer: Occur minutes to hours after repeat antigenic exposure
, ●● Delayed hypersensitivity reactions
Answer: Take several hours to occur, maximum reaction seen days after
reexposure
●● Anaphylaxis
Answer: - occurs within minutes of re-exposure
- Severity depends on the level of sensitization
- Symptoms: rash, hives, throat swelling
●● Type I Hypersensitivity process (3 steps)
Answer: • Occurs against environmental antigens (allergens)
• IgE binds to crystalline fragment (Fc) receptors on the
surface of mast cells
• Leads to degranulation and histamine release
"IgE binding to mast cells in response to antigen.. leads to degranulation
of mast cells (histamine)*
●● Leads to degranulation and histamine release (type I)
Answer: -- H1 and H2 receptors
-- Chemotactic activity (draws more immune cells to area and create
more of a reaction)
