SBB Final Exam Review | Actual Questions and Answers Latest
Updated 2026/2027 (Graded A+)
•
Band 3
i. - ✔✔macrocomplex of proteins including:
ii. -Rh
iii. -RhAG
iv. -LW (ICAM-4)
v. -GPA
vi. -GPB
vii. -CD47
•
ATP source for RBCs
i. - ✔✔90% from Glycolysis (Embden-Meyerhoff pathway)
ii. 10% from pentose phosphate pathway
•
Methemoglobin Reductase Pathway
i. - ✔✔necessary to maintain heme iron in ferrous (Fe2+) state
ii. Deficiency causes accumulation of methemoglobin, nonfunctional from of Hgb
•
Leubering Rapaport Shunt
- ✔✔permits accumulation of 2,3-DPG
•
"Tense form" of Hgb
i. - ✔✔DEOXYGENATED
ii. widening of beta-chain
iii. lower affinity for O2
iv. expels 2,3-DPG
•
"Relaxed form" of Hgb
i. - ✔✔OXYGENATED
ii. beta-chain pulled together
iii. higher affinity for O2
iv. expels 2,3-DPG
•
"Shift Right"
i. - ✔✔higher P50 value
,ii. decreased pH (increased H+ ion), acidosis
iii. increased 2,3-DPG
iv. higher temperature
v. high pCO2
•
Seen in compensated anemia
•
"Shift Left"
i. - ✔✔lower P50 value
ii. increased pH (decresed H+ ion), alkalosis
iii. decreasede 2,3-DPG
iv. lower temeratures
v. low pCO2
•
Seen in storage of RBC
•
Type 2 precursor
i. - ✔✔Gal-GlcNAc
ii. B1-4
•
Type 1 precursor
i. - ✔✔Gal-GlcNAc
ii. B1-3
•
Secreted (Se, Le)
•
Type 2 H antigen transeferase & Sugar
- ✔✔FUT-1
•
Alpha-2-L-fucosyltransferase
•
Fuctose alpha1-2
•
A antigen transferase & sugar
- ✔✔D-galactosaminetrasferase
,•
N-acetylgalactosamine alpha1-3
•
B antigen transferase & sugar
- ✔✔D-galacotsyltransferase
•
galactose alpha1-3
•
Ax subgroup
i. - ✔✔weakly positive anti-A
ii. weakly positive anti-A,B
•
Am subgroup
i. - ✔✔Negative anti-A
ii. Secretes A & H
•
Ael subgroup
i. - ✔✔Negative anti-A
ii. Secretes H only
•
Highest expression of H
Lowest expression of H
- ✔✔O>A2>B>A2B>A1>A1B> H deficient
•
Lewis transferase & Sugar
- ✔✔FUT-3
•
Fuctose alpha1-4
•
Type 1 H antigen transferase & sugar
- ✔✔FUT-2
•
Fuctose alpha1-2
•
anti-Le bh vs anti-Le bl
i. - ✔✔Anti-Le bh= reacts best with Leb & H are on rbc
, ii. reacts best with group O and A2
iii. does not react with A1 & B
•
Anti-Le bl= reacts independently of amount of H on rbc
best antisera to use when typing RBC
•
autoanti-H, -HI is most common in...
- ✔✔A1 patients, have the least amount of H
•
Elevated i antigen associated with...
i. - ✔✔cord cells
ii. reticulocytes in megaloblastic anemia
iii. leukemia
iv. stressed erythropoiesis
•
I gene
i. - ✔✔IGnT
ii. adds GlcNAc to Gal
iii. starts branching/ multivalent
•
anti-i associated with what disease
- ✔✔infectious mono
•
autoanti-i, -I commonly seen in patients with....
i. - ✔✔Mycoplasma pneumoniae infections
ii. Lymphoproliferative disorder (Waldenstrom macroglobinemia)
•
P1K & P2K lack what gene/ antigen
- ✔✔B3GalNAct1
•
missing P antigen (also Gb5 & LKE)
•
p lack what gene/ antigen
- ✔✔A4GALT
•
missing P1/PX2 & Pk (also P, Gb5 &LKE)
Updated 2026/2027 (Graded A+)
•
Band 3
i. - ✔✔macrocomplex of proteins including:
ii. -Rh
iii. -RhAG
iv. -LW (ICAM-4)
v. -GPA
vi. -GPB
vii. -CD47
•
ATP source for RBCs
i. - ✔✔90% from Glycolysis (Embden-Meyerhoff pathway)
ii. 10% from pentose phosphate pathway
•
Methemoglobin Reductase Pathway
i. - ✔✔necessary to maintain heme iron in ferrous (Fe2+) state
ii. Deficiency causes accumulation of methemoglobin, nonfunctional from of Hgb
•
Leubering Rapaport Shunt
- ✔✔permits accumulation of 2,3-DPG
•
"Tense form" of Hgb
i. - ✔✔DEOXYGENATED
ii. widening of beta-chain
iii. lower affinity for O2
iv. expels 2,3-DPG
•
"Relaxed form" of Hgb
i. - ✔✔OXYGENATED
ii. beta-chain pulled together
iii. higher affinity for O2
iv. expels 2,3-DPG
•
"Shift Right"
i. - ✔✔higher P50 value
,ii. decreased pH (increased H+ ion), acidosis
iii. increased 2,3-DPG
iv. higher temperature
v. high pCO2
•
Seen in compensated anemia
•
"Shift Left"
i. - ✔✔lower P50 value
ii. increased pH (decresed H+ ion), alkalosis
iii. decreasede 2,3-DPG
iv. lower temeratures
v. low pCO2
•
Seen in storage of RBC
•
Type 2 precursor
i. - ✔✔Gal-GlcNAc
ii. B1-4
•
Type 1 precursor
i. - ✔✔Gal-GlcNAc
ii. B1-3
•
Secreted (Se, Le)
•
Type 2 H antigen transeferase & Sugar
- ✔✔FUT-1
•
Alpha-2-L-fucosyltransferase
•
Fuctose alpha1-2
•
A antigen transferase & sugar
- ✔✔D-galactosaminetrasferase
,•
N-acetylgalactosamine alpha1-3
•
B antigen transferase & sugar
- ✔✔D-galacotsyltransferase
•
galactose alpha1-3
•
Ax subgroup
i. - ✔✔weakly positive anti-A
ii. weakly positive anti-A,B
•
Am subgroup
i. - ✔✔Negative anti-A
ii. Secretes A & H
•
Ael subgroup
i. - ✔✔Negative anti-A
ii. Secretes H only
•
Highest expression of H
Lowest expression of H
- ✔✔O>A2>B>A2B>A1>A1B> H deficient
•
Lewis transferase & Sugar
- ✔✔FUT-3
•
Fuctose alpha1-4
•
Type 1 H antigen transferase & sugar
- ✔✔FUT-2
•
Fuctose alpha1-2
•
anti-Le bh vs anti-Le bl
i. - ✔✔Anti-Le bh= reacts best with Leb & H are on rbc
, ii. reacts best with group O and A2
iii. does not react with A1 & B
•
Anti-Le bl= reacts independently of amount of H on rbc
best antisera to use when typing RBC
•
autoanti-H, -HI is most common in...
- ✔✔A1 patients, have the least amount of H
•
Elevated i antigen associated with...
i. - ✔✔cord cells
ii. reticulocytes in megaloblastic anemia
iii. leukemia
iv. stressed erythropoiesis
•
I gene
i. - ✔✔IGnT
ii. adds GlcNAc to Gal
iii. starts branching/ multivalent
•
anti-i associated with what disease
- ✔✔infectious mono
•
autoanti-i, -I commonly seen in patients with....
i. - ✔✔Mycoplasma pneumoniae infections
ii. Lymphoproliferative disorder (Waldenstrom macroglobinemia)
•
P1K & P2K lack what gene/ antigen
- ✔✔B3GalNAct1
•
missing P antigen (also Gb5 & LKE)
•
p lack what gene/ antigen
- ✔✔A4GALT
•
missing P1/PX2 & Pk (also P, Gb5 &LKE)
