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Narrow-spectrum antibiotics - ANSWER ✔✔Active against only a few
species of microorganisms
Broad-spectrum antibiotics - ANSWER ✔✔Active against a wide
variety of microbes
Do we usually order narrow or broad spectrum before we get culture
results? - ANSWER ✔✔Broad
Which is more likely (narrow or broad) to facilitate emergence of drug-
resistant organisms and superinfections? - ANSWER ✔✔Broad
,Which antibiotics drug CLASSES are contraindicated in pregnancy and
why? - ANSWER ✔✔Fluoroquinolones should be avoided due to
potential cartilage damage risk
Tetracyclines should be avoided due to potential tooth damage and
staining
What is the difference between bactericidal and bacteriostatic? -
ANSWER ✔✔Bactericidal=directly lethal to bacteria at clinically
achievable concentrations
Bacteriostatic=slow bacterial growth but don't cause cell death
Bactericidal Agents - ANSWER ✔✔Aminoglycosides
Beta-lactams
Fluoroquionolones
Metronidazole
Most antimycobacterial agents
Streptogramins
Vancomycin
Bacteriostatic Agents - ANSWER ✔✔Clindamycin
Macrolides
,Sulfonamides
Tetracyclines
What are the four basic mechanisms microbes have for resisting drugs?
- ANSWER ✔✔1) Decrease the concentration of a drug at its site of
action
2) Alter the structure of drug target molecules
3) Produce a drug antagonist
4) Cause drug inactivation
What is the most important patient education regarding antibiotics? -
ANSWER ✔✔It is imperative that antibiotics not be discontinued
prematurely
What classes of antibiotics are resistant to C. diff? - ANSWER
✔✔Aminoglycosides and cephalosporins
What are generally the best antibiotics to treat C. diff? - ANSWER
✔✔Flagyl or vancomycin
What is antibiotic stewardship? - ANSWER ✔✔Plan to combat
antimicrobial resistance
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, When is empiric therapy appropriate? - ANSWER ✔✔Patient has
severe infection, we may have to initiate treatment before test results are
available
What is the most common bacteria in CAP? - ANSWER ✔✔S.
pneumoniae
What are the drugs of choice for s. pneumoniae? - ANSWER
✔✔Penicillin G, Penicillin V, and amox in susceptible strains
Resistant=a cephalosporin, ampicillin
What is the most common bacteria in UTI? - ANSWER ✔✔E. coli
What is the first-line treatment for H. pylori? - ANSWER
✔✔Clarithromycin + amox + esomeprazole (PPI)
2nd line= tetracycline + flagyl + bismuth subsalicylate + PPI
What can sulfonamides cause in infants? - ANSWER ✔✔Can
produce kernicterus caused by diaplcement of bilirubin from plasma
proteins
What can gentamicin cause in infants? - ANSWER ✔✔If used in
infants, it can cause irreversible hearing loss