PNB 2265 EXAM 1 QUESTIONS AND
ANSWERS
MCV - Correct Answers -mean corpuscular volume
MCH/MCHC - Correct Answers -how much hb in the blood or in one blood cell
haldane effect - Correct Answers -deoxygenated hb has a higher affinity for co2
macrocytic anemia - Correct Answers -larger than normal rbc, shows up in the MCV
-cells are bigger and lose their biconcavity and become spherical which decreases the
hb count
-hematocrit does not show this disease
-pernicious anemia
CO (carbon monoxide poisoning) - Correct Answers -CO binds (better than O2) to iron
in the same spot O2 does
-competitive antagonist
-removes ability of hb to move oxygen to tissues
-hyperbaric chamber
cyaninde poisoning - Correct Answers -similar mechanism as CO but not a competitive
antagonist
-binds to hb but not to Fe, only uses hb to carry it to tissues in the body
pernicious anemia - Correct Answers -vitamin b12 deficiency that is necessary for the
control of rbc morphology
-elderly women and gastric bypass patients
microcytic anemia - Correct Answers -smaller than normal rbc
-can not fit as much hb within cells
-can prove with a hematocrit
causes:
-iron deficiency: not forming as much hb so smaller rbc
-thalassemia: genetic mutation in hb
sickle cell anemia - Correct Answers -inheritable genetic mutation in the hb beta chain
-hb morphed into crescents
-hb becomes "sticky" and aggregates inside cells
-treatment: butyrate: stimulates the production of HbF production
polycythemia - Correct Answers -over-stimulation of EPO or receptor for EPO
-too many rbc, thickens blood by increasing formed elements to plasma ratio
ANSWERS
MCV - Correct Answers -mean corpuscular volume
MCH/MCHC - Correct Answers -how much hb in the blood or in one blood cell
haldane effect - Correct Answers -deoxygenated hb has a higher affinity for co2
macrocytic anemia - Correct Answers -larger than normal rbc, shows up in the MCV
-cells are bigger and lose their biconcavity and become spherical which decreases the
hb count
-hematocrit does not show this disease
-pernicious anemia
CO (carbon monoxide poisoning) - Correct Answers -CO binds (better than O2) to iron
in the same spot O2 does
-competitive antagonist
-removes ability of hb to move oxygen to tissues
-hyperbaric chamber
cyaninde poisoning - Correct Answers -similar mechanism as CO but not a competitive
antagonist
-binds to hb but not to Fe, only uses hb to carry it to tissues in the body
pernicious anemia - Correct Answers -vitamin b12 deficiency that is necessary for the
control of rbc morphology
-elderly women and gastric bypass patients
microcytic anemia - Correct Answers -smaller than normal rbc
-can not fit as much hb within cells
-can prove with a hematocrit
causes:
-iron deficiency: not forming as much hb so smaller rbc
-thalassemia: genetic mutation in hb
sickle cell anemia - Correct Answers -inheritable genetic mutation in the hb beta chain
-hb morphed into crescents
-hb becomes "sticky" and aggregates inside cells
-treatment: butyrate: stimulates the production of HbF production
polycythemia - Correct Answers -over-stimulation of EPO or receptor for EPO
-too many rbc, thickens blood by increasing formed elements to plasma ratio
