MAT waiver 8 hour training Module 2 Exam | Actual Questions
and Answers Latest Updated 2026/2027 (Graded A+)
•
What does it mean when you say buprenorphine has a strong affinity?
- ✔✔It will displace the full mu receptor agonist like heroin and methadone.
•
How does Buprenorphine work?
- ✔✔It stays on receptor for a long time and blocks heroin or other opioids from binding to
that receptor. This is called dissipate where the speed of disengaging off a receptor is slow.
•
What is spontaneous withdrawal?
i. - ✔✔- with short acting opioids like heroine and oxycodone, begins in 6-12 hours after last
dose and peaks 36-72 hours.
ii. - it last about 5 days
•
What is spontaneous withdrawal with opioids with longer half lives such as methadone?
- ✔✔Begin 36- 72 hours after last dose with longer period before peak is reached.
•
How does methadone work in OUD?
- ✔✔Activates opioid receptor in brain and blocks effect of heroin and causes less cravings
•
How does buprenorphine work in OUD?
- ✔✔Partial activation of opioid receptor thus decreasing drug use and protect from
overdose.
•
What drug can be used in OUD once taper off buprenorphine?
- ✔✔Naltrexone
•
How does Naltrexone work in OUR?
i. - ✔✔Antagonist opioid
ii. - must be off opioids 7 days and is normally used after detox to prevent relapse.
iii. Monthly injection or oral 30 days
•
What is protracted Abstinence Syndrome?
- ✔✔- it is secondary to derangement of endogenous opioid receptor. The s/s are: malaise,
fatigue, insomnia, poor tolerance, opioid cravings
and Answers Latest Updated 2026/2027 (Graded A+)
•
What does it mean when you say buprenorphine has a strong affinity?
- ✔✔It will displace the full mu receptor agonist like heroin and methadone.
•
How does Buprenorphine work?
- ✔✔It stays on receptor for a long time and blocks heroin or other opioids from binding to
that receptor. This is called dissipate where the speed of disengaging off a receptor is slow.
•
What is spontaneous withdrawal?
i. - ✔✔- with short acting opioids like heroine and oxycodone, begins in 6-12 hours after last
dose and peaks 36-72 hours.
ii. - it last about 5 days
•
What is spontaneous withdrawal with opioids with longer half lives such as methadone?
- ✔✔Begin 36- 72 hours after last dose with longer period before peak is reached.
•
How does methadone work in OUD?
- ✔✔Activates opioid receptor in brain and blocks effect of heroin and causes less cravings
•
How does buprenorphine work in OUD?
- ✔✔Partial activation of opioid receptor thus decreasing drug use and protect from
overdose.
•
What drug can be used in OUD once taper off buprenorphine?
- ✔✔Naltrexone
•
How does Naltrexone work in OUR?
i. - ✔✔Antagonist opioid
ii. - must be off opioids 7 days and is normally used after detox to prevent relapse.
iii. Monthly injection or oral 30 days
•
What is protracted Abstinence Syndrome?
- ✔✔- it is secondary to derangement of endogenous opioid receptor. The s/s are: malaise,
fatigue, insomnia, poor tolerance, opioid cravings
