--•.-- - . 2 \e. )(1' •; _. ti
1/Jtr.,l'--\,i'-'• 2-.3 - Z6I 2. [- 3 �
White Version
Biochemistry I, Chem 4600
- -
cH· 2.'f>
_�i:�,..',, '•-
Dr, Ray
v.51: i-:� ,S, !:,
l-f •, I , '3'"5 'Ir.
:••., , .. •� , . ...... . l• .. •! ;, ••• • .• •. ':.;;. ._•.:',i,f':',"' . ..•r::,..-.."{i,;:.:: ::. � • ,'I -"\-...,• •-• ••., ;,
Choose the one best answer for each question and· fill in the Seillltron form. \tJ � : se 1
J {,,:i-� ,'2-1
Additional figures and tables are at the end of the exam. You have a maximum of2 boursto
complete this exam. , .. -.
. · Prol. 1 1,3/i,i
J. Reactions can proceed spontaneously only when:· ... . .-
A) no change in entropy takes place lv o;,1'-l:¥- C\t .31
B) no change in enthalpy takes place S'elf: _1.,;1.. ,b
�ee energy is added (positive)
�ere is a decrease in free energy (negative)
E) the free energy change is equal to zero
�Ir 2-9
2. In living cells nucleotides and/or nucleic acids:
T-e..x-r: 3 .,,f (cl1e ,'t) , '
A)
B)
carry metabolic energy.
serve as intracellular signaling molecules.
(Jj\c.B le- 5�\t: ;,. /3, f
11-1'?>,n
C) participate in the transfer of genetic information into" proteins. �l,,i:,d,} �
D} store genetic information.
all of the other choices are tru.e.
. ! �, '2c>, z t·
3. Which ofthe following statements about buffers is TRUE! · f�i.,-. !. ,, I I
the pH of a buffered solution remains constant no matter how much acid or base
is added to the solution
the strongest buffers are those composed ofstrong acids and strong bases
a buffer composed ofa weak acid ofpK.. = 5 is stronger at pH 4_ than at pH 6
when pH= pK.., the concentrations of acid and its conjugate base present in a
buffer are equal
none of the other llllSWCrs are correct
4. I n the Watson-Crick model for the DNA double helix (B form) the A-T and G·-C base
pairs share all but one of the following properties. Which is the EXCEfTTON?
A pyrimidine in one strand ofDNA always hydrogen bonds with a purine in the
opposite strand.
The number ofhydrogen bonds formed between the two bases oflhe base pair is
the same.
C) The plane of the basepnir is roughly perpendicular to the a,'tls of the helix in each
case.
D) All of the functional groups in the major groove are in their neutra� not ionized
forms.
E) The distance between the two glycosidic (base-sugar) bonds is the same in both
base pairs, within a few tenths of an angstrom.
, dytholirobic inrd@tioB !02&ei4oliet @getic @dributios ro:
A) prot iltattiet str.,tu
B) Foief qualc@y dtlctE
C) 6zyd.'$bstratcdt@.li@B
:D\ n.DbEG 3trst@
(g/ 6! ortbeo'''( a oreL
"hoics
\i/ Tfielhosdodi.sld boldthaijoi!5 adlEenrnehottd.si! DNA:
is $ic.ptiblc to alelbe hydrcb'ris
a$ciald ionicaly *irh mrid jo8 rld catiolic prot.its
lirls C-3' ot deoqa:bo* ro a dDgq oftrni4 o. ctrosin
i6 ucbatg.d !r @udalpH
?. Aceryl.CoAi3 i,lporiantb.r@ n: C- C
A) i5 a ts @bo! uil wil! {D highgroupLsf.r por@rislof! rhio€t6..
B) Etuhs-FoDdasb.!'lriotr ofp)rutle by rh€lyruva. dc.lrydro8@ otrpter
i5 rn. 6@ i, $hj. h dboE toE 6bobydrar6 drq Lh.cirric eid cycb.
- C) .e besed srne buildiogbtoct tor gtry @tis whc, &o €[ !$ d 6dcqu]e sulpl:r of ATi
D)
i4olB dll of th. ofts ctoi6,
8. lvlos kiMs€sch4gc .olfomarion uponbindi!8 th€oigsDtcebstrlte b..ate
A) Irey @ Egrht€d byATP
B) Ibet @ kinclicsly p.r€ct
C) They@d oily oE krs @bcalc iDth€.crive lnc
O Neledes bydrc'r%phos?rodie$obondsin do b&Iborc ofDuteic eids.
u) uryc$yrr*s hydrotu eL.ratli,t!8s in d;sa!htud6 ald
lotysaeh{idei
Et rrerldrcs.naB u c'.te qn oratyzesin?k odarionssuchs a1
Le-'n.rtnk&id
ro a |{l onetor LomD o{da, io6 coupkdro decdborylation@ojoB. "tcohol
1/Jtr.,l'--\,i'-'• 2-.3 - Z6I 2. [- 3 �
White Version
Biochemistry I, Chem 4600
- -
cH· 2.'f>
_�i:�,..',, '•-
Dr, Ray
v.51: i-:� ,S, !:,
l-f •, I , '3'"5 'Ir.
:••., , .. •� , . ...... . l• .. •! ;, ••• • .• •. ':.;;. ._•.:',i,f':',"' . ..•r::,..-.."{i,;:.:: ::. � • ,'I -"\-...,• •-• ••., ;,
Choose the one best answer for each question and· fill in the Seillltron form. \tJ � : se 1
J {,,:i-� ,'2-1
Additional figures and tables are at the end of the exam. You have a maximum of2 boursto
complete this exam. , .. -.
. · Prol. 1 1,3/i,i
J. Reactions can proceed spontaneously only when:· ... . .-
A) no change in entropy takes place lv o;,1'-l:¥- C\t .31
B) no change in enthalpy takes place S'elf: _1.,;1.. ,b
�ee energy is added (positive)
�ere is a decrease in free energy (negative)
E) the free energy change is equal to zero
�Ir 2-9
2. In living cells nucleotides and/or nucleic acids:
T-e..x-r: 3 .,,f (cl1e ,'t) , '
A)
B)
carry metabolic energy.
serve as intracellular signaling molecules.
(Jj\c.B le- 5�\t: ;,. /3, f
11-1'?>,n
C) participate in the transfer of genetic information into" proteins. �l,,i:,d,} �
D} store genetic information.
all of the other choices are tru.e.
. ! �, '2c>, z t·
3. Which ofthe following statements about buffers is TRUE! · f�i.,-. !. ,, I I
the pH of a buffered solution remains constant no matter how much acid or base
is added to the solution
the strongest buffers are those composed ofstrong acids and strong bases
a buffer composed ofa weak acid ofpK.. = 5 is stronger at pH 4_ than at pH 6
when pH= pK.., the concentrations of acid and its conjugate base present in a
buffer are equal
none of the other llllSWCrs are correct
4. I n the Watson-Crick model for the DNA double helix (B form) the A-T and G·-C base
pairs share all but one of the following properties. Which is the EXCEfTTON?
A pyrimidine in one strand ofDNA always hydrogen bonds with a purine in the
opposite strand.
The number ofhydrogen bonds formed between the two bases oflhe base pair is
the same.
C) The plane of the basepnir is roughly perpendicular to the a,'tls of the helix in each
case.
D) All of the functional groups in the major groove are in their neutra� not ionized
forms.
E) The distance between the two glycosidic (base-sugar) bonds is the same in both
base pairs, within a few tenths of an angstrom.
, dytholirobic inrd@tioB !02&ei4oliet @getic @dributios ro:
A) prot iltattiet str.,tu
B) Foief qualc@y dtlctE
C) 6zyd.'$bstratcdt@.li@B
:D\ n.DbEG 3trst@
(g/ 6! ortbeo'''( a oreL
"hoics
\i/ Tfielhosdodi.sld boldthaijoi!5 adlEenrnehottd.si! DNA:
is $ic.ptiblc to alelbe hydrcb'ris
a$ciald ionicaly *irh mrid jo8 rld catiolic prot.its
lirls C-3' ot deoqa:bo* ro a dDgq oftrni4 o. ctrosin
i6 ucbatg.d !r @udalpH
?. Aceryl.CoAi3 i,lporiantb.r@ n: C- C
A) i5 a ts @bo! uil wil! {D highgroupLsf.r por@rislof! rhio€t6..
B) Etuhs-FoDdasb.!'lriotr ofp)rutle by rh€lyruva. dc.lrydro8@ otrpter
i5 rn. 6@ i, $hj. h dboE toE 6bobydrar6 drq Lh.cirric eid cycb.
- C) .e besed srne buildiogbtoct tor gtry @tis whc, &o €[ !$ d 6dcqu]e sulpl:r of ATi
D)
i4olB dll of th. ofts ctoi6,
8. lvlos kiMs€sch4gc .olfomarion uponbindi!8 th€oigsDtcebstrlte b..ate
A) Irey @ Egrht€d byATP
B) Ibet @ kinclicsly p.r€ct
C) They@d oily oE krs @bcalc iDth€.crive lnc
O Neledes bydrc'r%phos?rodie$obondsin do b&Iborc ofDuteic eids.
u) uryc$yrr*s hydrotu eL.ratli,t!8s in d;sa!htud6 ald
lotysaeh{idei
Et rrerldrcs.naB u c'.te qn oratyzesin?k odarionssuchs a1
Le-'n.rtnk&id
ro a |{l onetor LomD o{da, io6 coupkdro decdborylation@ojoB. "tcohol
