Summary Week 4 Anxiolytic Medication Table Pharmacology Study Guide

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12/17/23, 8:09 PM Week 4 Anxiolytic Table



Anxiolytic Medications


Drug Name/ Indication Associated Half-life Notable side effects
Medication list diagnosis and targeted Neurotransm (T1/2)
class symptoms itters Metabolism
(CYP 450
enyzme)
Gabapentin  Partial seizures with or Glutamate, Renally Sedation dose dependant, dizziness, Ataxia dose dependant,
without secondary Voltage excreted 5-7 fatigue, nystagmus, tremor, peripheral edema, blurred vision,
generalization - goal is Gated hours vomiting, dyspepsia, diarrhea, dry mouth, constipation, weight gain.
complete remission of Calcium
seizures channel CYP450 For children <12 y/o hostility, emotional liability, hyperkinesia,
 Post Herpetic neuralgia – blocker. enzymes not thought disorder, weight gain.
reduce pain in 2 weeks inhibited nor
 restless leg syndrome (XR) Binds to the induced
 Neuropathic pain/chronic alpha 2 delta
pain – reduce neuropathic subunit of
pain coltage
 Anxiety (adjunctive) – sensitive
reduce anxiety in 2 weeks calcium
 Bipolar Disorder channels.
(Adjunctive) – possible
mood stabilizing effects in
2 weeks.

Pregabalin Diabetic peripheral Glutamate, CYP450 Sedation, Dizziness,Ataxia, fatigue, tremor, dysarthria, paresthesia,
neuropathy Voltage enzymes not memory impairment, coordination abnormal, impaired attention,
Post herpetic neuralgia Gated inhibited nor confusion, euphoric mood, irritability, vomiting, dry mouth,
Fibromyalgia Calcium induced constipation, weight gain, increased appetite, flatulence, blurred
Neuropathic pain associated channel vision, diplopia, peripheral edema, libido decreases, erectile
with spinal cord injury blocker. dysfunction.
Partial onset of seizures
Peripheral neuropathic pain Potent
Generalized anxiety disorder ligand for
Panic disorder the alpha-
Social anxiety disorder 2-delta

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12/17/23, 8:09 PM Week 4 Anxiolytic Table




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12/17/23, 8:09 PM Week 4 Anxiolytic Table



Anxiolytic Medications


subunit of
Can reduce neuropathic pain voltage-
and anxiety in 1 week gated
Reduce seizures by 2 weeks calcium
If not clinical benefit is seen in channels
6-8 weeks than dose may need in the
adjustment or may not work at central
all. nervous
system
that
exhibits
potent
anticonvul
sant,
analgesic,
and
anxiolytic
activity in
a range of
animal
models


Buspirone For mixed anxiety and Serotonin Metabolized Dizziness, headache, nervousness, sedation, excitement, nausea,
depression receptor by CYP450 restlessness.
partial 3A4.
Treatment resistant depression agonist Elimination Rare Cardiac Symptoms
half life 2-3
Goal is complete remission of Serotonin hours
symptoms and prevention of stabilizer absorption
future relapses affected by
food.
Symptoms can recur after
medication is stopped, chronic
anxiety disorder may require

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