TEST BANK FOR CLINICAL
IMMUNOLOGY AND SEROLOGY A
LABORATORY PERSPECTIVE FIFTH
EDITION BY CHRISTINE
DORRESTEYN MILLER ISBN 10;
0803694407/ISBN-13; 978-
0803694408 COMPLETE GUIDE A+
TEST BANK FOR CLINICAL IMMUNOLOGY AND SEROLOGY: A LABORATORY PERSPECTIVE, 5TH EDITION
Chapter 1: Introduction to Immunity and the Immune System
1. Eosinophils are involved in the immune response against:
A. viruses.
B. intracellular bacteria.
C. parasites that cannot be phagocytized.
D. extracellular bacteria.
ANS: C
Rationale: Eosinophils are specialized granulocytes that primarily defend against large parasites
(helminths) that cannot be phagocytized. They release major basic protein and other toxic granule
contents onto the parasite surface.
2. Which of the following are components of both innate and adaptive immune responses?
A. Immunoglobulins
B. T helper cells
C. Macrophages
D. B cells
ANS: C
Rationale: Macrophages participate in innate immunity through phagocytosis and in adaptive immunity
as antigen-presenting cells that activate T cells. Immunoglobulins, T helper cells, and B cells are
components of adaptive immunity only.
,3. The process by which leukocytes are attracted to a specific area by chemical messengers is called:
A. diapedesis.
B. degranulation.
C. chemotaxis.
D. opsonization.
ANS: C
Rationale: Chemotaxis is the directed movement of leukocytes toward increasing concentrations of
chemical messengers (chemokines/cytokines) released at sites of infection or inflammation.
4. Which of the following is a characteristic of natural killer cells?
A. They mature in the thymus.
B. They are smaller than B and T cells.
C. They are a type of lymphocyte.
D. They are part of the adaptive immune system.
ANS: C
Rationale: NK cells are a type of lymphocyte (large granular lymphocyte) that participate in innate
immunity. They do not mature in the thymus (that is T cells) and are part of innate, not adaptive,
immunity.
5. Which of the following best describes diapedesis?
A. Movement toward increasing concentrations of a cytokine
B. Attachment of immunoglobulin to target cells
ANS: Not provided in source (question incomplete in source)
Rationale: Diapedesis is the process by which leukocytes squeeze through the endothelial cell junctions
of blood vessel walls to migrate into tissues at sites of infection or inflammation.
6. The most effective phagocytic and antigen-presenting cell is the:
A. neutrophil.
B. monocyte.
C. dendritic cell.
D. macrophage.
ANS: C
,Rationale: Dendritic cells are the most potent antigen-presenting cells, capable of activating naive T
cells. While macrophages are excellent phagocytes, dendritic cells are superior in antigen presentation.
7. Which of the following is characteristic of natural immunity?
A. It involves memory.
B. T lymphocytes play a major role.
C. It involves specificity.
D. Mechanisms are always present and fully functional.
ANS: D
Rationale: Natural (innate) immunity is characterized by mechanisms that are always present and fully
functional from birth, providing immediate protection without prior exposure to pathogens.
8. All of the following cells are considered part of natural immunity EXCEPT:
A. eosinophils.
B. B lymphocytes.
C. monocytes.
D. neutrophils.
ANS: B
Rationale: B lymphocytes are part of adaptive immunity, responsible for humoral immunity and
antibody production. Eosinophils, monocytes, and neutrophils are all innate immune cells.
9. Where does the specific immune response to a foreign antigen mainly occur?
A. Lymph nodes
B. Blood
C. Bone marrow
D. Skin
ANS: A
Rationale: Lymph nodes are secondary lymphoid organs where antigen-presenting cells interact with T
and B lymphocytes, initiating specific adaptive immune responses.
10. Which white cell in the peripheral blood migrates into tissue to become a macrophage?
A. Eosinophil
B. Basophil
, C. Neutrophil
D. Monocyte
ANS: D
Rationale: Monocytes circulate in peripheral blood and migrate into tissues where they differentiate
into macrophages (e.g., Kupffer cells in liver, alveolar macrophages in lungs).
11. A white blood cell that is 16 to 18 micrometers in diameter, has a horseshoe-shaped nucleus, and
is capable of phagocytosis is a:
A. neutrophil.
B. eosinophil.
C. basophil.
D. monocyte.
ANS: D
Rationale: Monocytes are the largest white blood cells (16-18 μm), have a horseshoe-shaped or kidney-
shaped nucleus, and are highly phagocytic.
12. Pasteur's discovery that older bacterial cultures would not cause disease in chickens but would
protect them from subsequent infection with more virulent strains is an example of:
A. attenuated vaccine.
B. natural immunity.
C. passive immunity.
D. cross-immunity.
ANS: A
Rationale: Pasteur's work with attenuated (weakened) bacterial cultures led to the development of live
attenuated vaccines, which provide protection without causing disease.
13. Antibodies are secreted by:
A. plasma cells.
B. B cells.
C. T cells.
D. dendritic cells.
ANS: A
IMMUNOLOGY AND SEROLOGY A
LABORATORY PERSPECTIVE FIFTH
EDITION BY CHRISTINE
DORRESTEYN MILLER ISBN 10;
0803694407/ISBN-13; 978-
0803694408 COMPLETE GUIDE A+
TEST BANK FOR CLINICAL IMMUNOLOGY AND SEROLOGY: A LABORATORY PERSPECTIVE, 5TH EDITION
Chapter 1: Introduction to Immunity and the Immune System
1. Eosinophils are involved in the immune response against:
A. viruses.
B. intracellular bacteria.
C. parasites that cannot be phagocytized.
D. extracellular bacteria.
ANS: C
Rationale: Eosinophils are specialized granulocytes that primarily defend against large parasites
(helminths) that cannot be phagocytized. They release major basic protein and other toxic granule
contents onto the parasite surface.
2. Which of the following are components of both innate and adaptive immune responses?
A. Immunoglobulins
B. T helper cells
C. Macrophages
D. B cells
ANS: C
Rationale: Macrophages participate in innate immunity through phagocytosis and in adaptive immunity
as antigen-presenting cells that activate T cells. Immunoglobulins, T helper cells, and B cells are
components of adaptive immunity only.
,3. The process by which leukocytes are attracted to a specific area by chemical messengers is called:
A. diapedesis.
B. degranulation.
C. chemotaxis.
D. opsonization.
ANS: C
Rationale: Chemotaxis is the directed movement of leukocytes toward increasing concentrations of
chemical messengers (chemokines/cytokines) released at sites of infection or inflammation.
4. Which of the following is a characteristic of natural killer cells?
A. They mature in the thymus.
B. They are smaller than B and T cells.
C. They are a type of lymphocyte.
D. They are part of the adaptive immune system.
ANS: C
Rationale: NK cells are a type of lymphocyte (large granular lymphocyte) that participate in innate
immunity. They do not mature in the thymus (that is T cells) and are part of innate, not adaptive,
immunity.
5. Which of the following best describes diapedesis?
A. Movement toward increasing concentrations of a cytokine
B. Attachment of immunoglobulin to target cells
ANS: Not provided in source (question incomplete in source)
Rationale: Diapedesis is the process by which leukocytes squeeze through the endothelial cell junctions
of blood vessel walls to migrate into tissues at sites of infection or inflammation.
6. The most effective phagocytic and antigen-presenting cell is the:
A. neutrophil.
B. monocyte.
C. dendritic cell.
D. macrophage.
ANS: C
,Rationale: Dendritic cells are the most potent antigen-presenting cells, capable of activating naive T
cells. While macrophages are excellent phagocytes, dendritic cells are superior in antigen presentation.
7. Which of the following is characteristic of natural immunity?
A. It involves memory.
B. T lymphocytes play a major role.
C. It involves specificity.
D. Mechanisms are always present and fully functional.
ANS: D
Rationale: Natural (innate) immunity is characterized by mechanisms that are always present and fully
functional from birth, providing immediate protection without prior exposure to pathogens.
8. All of the following cells are considered part of natural immunity EXCEPT:
A. eosinophils.
B. B lymphocytes.
C. monocytes.
D. neutrophils.
ANS: B
Rationale: B lymphocytes are part of adaptive immunity, responsible for humoral immunity and
antibody production. Eosinophils, monocytes, and neutrophils are all innate immune cells.
9. Where does the specific immune response to a foreign antigen mainly occur?
A. Lymph nodes
B. Blood
C. Bone marrow
D. Skin
ANS: A
Rationale: Lymph nodes are secondary lymphoid organs where antigen-presenting cells interact with T
and B lymphocytes, initiating specific adaptive immune responses.
10. Which white cell in the peripheral blood migrates into tissue to become a macrophage?
A. Eosinophil
B. Basophil
, C. Neutrophil
D. Monocyte
ANS: D
Rationale: Monocytes circulate in peripheral blood and migrate into tissues where they differentiate
into macrophages (e.g., Kupffer cells in liver, alveolar macrophages in lungs).
11. A white blood cell that is 16 to 18 micrometers in diameter, has a horseshoe-shaped nucleus, and
is capable of phagocytosis is a:
A. neutrophil.
B. eosinophil.
C. basophil.
D. monocyte.
ANS: D
Rationale: Monocytes are the largest white blood cells (16-18 μm), have a horseshoe-shaped or kidney-
shaped nucleus, and are highly phagocytic.
12. Pasteur's discovery that older bacterial cultures would not cause disease in chickens but would
protect them from subsequent infection with more virulent strains is an example of:
A. attenuated vaccine.
B. natural immunity.
C. passive immunity.
D. cross-immunity.
ANS: A
Rationale: Pasteur's work with attenuated (weakened) bacterial cultures led to the development of live
attenuated vaccines, which provide protection without causing disease.
13. Antibodies are secreted by:
A. plasma cells.
B. B cells.
C. T cells.
D. dendritic cells.
ANS: A
