Pharmacokinetics and Pharmacodynamics Exam Questions with
Correct Answers
Question 1.
What is pharmacoki-netics?
Correct Answer: -movement of drugs through the body
-it basically describes how the body deals with medications going through-out
body and the effects on the body
Question 2.
List the four phases for pharmacokinetics and the major organ/sys-tem for each phase.
Correct Answer: -absorption (stomach and small intestines)
-distribution (circulatory system, blood)
-metabolism (liver)
-excretion (urinary system)
Question 3.
Define absorption.
Correct Answer: movement of a drug from the site of administration to
fluid (blood stream)
Question 4.
What is the primary factor determining the length of time for drug effect to occur?
Correct Answer: absorption
Question 5.
Which route of admin-istration provides the fastest absorption?
Correct Answer: intravenous or intraosseous (30-60 seconds)
Question 6.
Which route of admin-istration is the slow-est?
Correct Answer: ingestion (30-90. minutes)
Question 7.
Explain why drugs giv-en at larger doses will absorb at a faster rate.
Correct Answer: Drugs administered in high doses are generally absorbed more
and have a more rapid onset of action than those given in low doses.
Question 8.
What is the first 'P' of pharmacokinetics that deals with absorption? How does it affect the
, absorption of medica-tions?
Correct Answer: -pH
-the medication will not absorb properly if the stomach is not at its normal pH
(ex. if the patient takes TUMS, it has neutralized the stomach and the
won't work)
Question 9.
A client likes to take his medications with his big morning break-fast. Considering the
absorption of meds, why is this a problem?
Correct Answer: -food may effect the pH of the stomach, which will effect the
of the drug
-it will also cause a slower absorption of the drugs since they are added with
Question 10.
What is the second 'P' of pharmacokinet-ics that is involved in metabolism
(biotrans-formation)?
Correct Answer: p-450
Question 11.
Identify the sub-stances discussed in class that are p-450 en-zyme inducers.
Correct Answer: -Rifampicin (antibiotic)
-Phenytoin (seizure)
-Phenobarbitore (antiseizure)
Question 12.
How do the p-450 in-ducers affect medica-tions that are adminis-tered concurrently?
Correct Answer: if a drug is given with an enzyme inDucer, it will have a
activity of the second drug (increased exertion. of Drug #2)
Question 13.
Identify the sub-stances discussed in class that are p-450 in-hibitors.
Correct Answer: -Cimetadine (Tagament)
-Antifungal meds (ending in -azole)
-antibiotics (fluoroquinolone, macrolides, sulfonamides)
-grapefruit juice
-selctive serotonin reuptake inhibitors (SSRIs) (Prozac= fluoxetine,
Question 14.
How do the p-450 in-hibitors affect medica-tions that are adminis-tered concurrently?
Correct Answer: if a drug is given with an inHibitor, there is HEIGHTENED
(toxic levels) of the second drug
Question 15.
Correct Answers
Question 1.
What is pharmacoki-netics?
Correct Answer: -movement of drugs through the body
-it basically describes how the body deals with medications going through-out
body and the effects on the body
Question 2.
List the four phases for pharmacokinetics and the major organ/sys-tem for each phase.
Correct Answer: -absorption (stomach and small intestines)
-distribution (circulatory system, blood)
-metabolism (liver)
-excretion (urinary system)
Question 3.
Define absorption.
Correct Answer: movement of a drug from the site of administration to
fluid (blood stream)
Question 4.
What is the primary factor determining the length of time for drug effect to occur?
Correct Answer: absorption
Question 5.
Which route of admin-istration provides the fastest absorption?
Correct Answer: intravenous or intraosseous (30-60 seconds)
Question 6.
Which route of admin-istration is the slow-est?
Correct Answer: ingestion (30-90. minutes)
Question 7.
Explain why drugs giv-en at larger doses will absorb at a faster rate.
Correct Answer: Drugs administered in high doses are generally absorbed more
and have a more rapid onset of action than those given in low doses.
Question 8.
What is the first 'P' of pharmacokinetics that deals with absorption? How does it affect the
, absorption of medica-tions?
Correct Answer: -pH
-the medication will not absorb properly if the stomach is not at its normal pH
(ex. if the patient takes TUMS, it has neutralized the stomach and the
won't work)
Question 9.
A client likes to take his medications with his big morning break-fast. Considering the
absorption of meds, why is this a problem?
Correct Answer: -food may effect the pH of the stomach, which will effect the
of the drug
-it will also cause a slower absorption of the drugs since they are added with
Question 10.
What is the second 'P' of pharmacokinet-ics that is involved in metabolism
(biotrans-formation)?
Correct Answer: p-450
Question 11.
Identify the sub-stances discussed in class that are p-450 en-zyme inducers.
Correct Answer: -Rifampicin (antibiotic)
-Phenytoin (seizure)
-Phenobarbitore (antiseizure)
Question 12.
How do the p-450 in-ducers affect medica-tions that are adminis-tered concurrently?
Correct Answer: if a drug is given with an enzyme inDucer, it will have a
activity of the second drug (increased exertion. of Drug #2)
Question 13.
Identify the sub-stances discussed in class that are p-450 in-hibitors.
Correct Answer: -Cimetadine (Tagament)
-Antifungal meds (ending in -azole)
-antibiotics (fluoroquinolone, macrolides, sulfonamides)
-grapefruit juice
-selctive serotonin reuptake inhibitors (SSRIs) (Prozac= fluoxetine,
Question 14.
How do the p-450 in-hibitors affect medica-tions that are adminis-tered concurrently?
Correct Answer: if a drug is given with an inHibitor, there is HEIGHTENED
(toxic levels) of the second drug
Question 15.
