BREAST CANCER COMPLICATIONS OF CHEMOTHERAPY EXAM SCRIPT COMPREHENSIVE STUDY GUIDE

BREAST CANCER COMPLICATIONS OF
CHEMOTHERAPY EXAM SCRIPT
COMPREHENSIVE STUDY GUIDE

●● Percentage of women with breast cancer who have zero known risk
factors?
Answer: 75%


●● Percentage of all breast cancers in women <30 years?
Answer: ~2%


●● Percentage of all breast cancers in women >70 years?
Answer: 33%


●● Percentage of breast cancers due to inherited mutations?
Answer: 10%


●● Approximate percentage of inherited breast cancers due to BRCA
1/2?
Answer: ~50%


(5% of all breast cancers)

,●● What is the expected ER status of BRCA 1 vs BRCA 2 breast
cancers?
Answer: BRCA 1 ER negative (~70%)
BRCA 2 ER positive (~70%)


●● Name some breast cancer susceptibility genes
Answer: BRCA 1/2
Tp53 (Li Fraumeni)
PTEN
STK11 (Peutz-Jeghers)
PTALB
CDH1


●● How do you decrease breast cancer risk in women with BRCA
mutations?
Answer: Prophylactic bilateral mastectomy (90% risk reduction)
+prophylactic BSO -> 95% risk reduction


Rule o' Thumb: 5 years before the earliest onset of cancer in mom


●● What is the preferred screening for mutation carriers?
Answer: MRI annually

, ●● Most common motivation for medicological cases of the breast
Answer: Failure to diagnose a breast carcinoma


●● Triad of Error for misdiagnosis of breast cancer
Answer: 1) Age <45 years
2) Self-diagnosed mass
3) Negative mammogram


●● Hx breast cancer risk factors?
Answer: NAACP
Nulliparity
Age at menarche (<13 yrs)
Age at menopause (>55 yrs)
Breast cancer (self, family)
Pregnancy of 1st child >30yrs


●● Physical breast cancer risk factors?
Answer: CHAFED LIPS
Cancer in breast (3% synchronous contralat)
Hyperplasia (2x)
Atypical hyperplasia (4x)