BIOCHEM C785 MIDTERM 2 COMPREHENSIVE
SCRIPT WITH SOLUTIONS
◉ Heparan Sulfate.
Answer: GAG that inhibits coagulation
◉ Glycoconjugates.
Answer: Carbohydrates connected to protiens or lipids
◉ Proteogylcans.
Answer: A glycoconjugate found in animal cells with a LONG core
protein and has GAGS attached
Interact through electrostatic interactions
◉ Syndecans.
Answer: Single transmembrane domain and an extracellular domain
bearing 3-5 chains of heparan sulfate and chondroitin sulfate.
Core protein goes through full membrane with a COO- at the bottom.
◉ Glypican.
,Answer: A heparan sulfate proteoglycan attached to a membrane
through a glycosyl phosphatidylinositol (GPI) anchor (a lipid).
◉ What are syndecans and glypicans cleaved by?.
Answer: Syndecans: protease
Glypicans: Lipase
◉ Glycoprotiens.
Answer: Protiens with one or more short oligosaccharides
covalently attached
Help with signalling
◉ The two types of gylcoprotiens.
Answer: O-linked: Anomeric carbon linked through OH at Ser or Thr
N-linked: Anomeric carbon linked through amide nitrogen of Asn
◉ Mucins.
Answer: Glycoproteins that are primarily responsible for the
lubricating action of saliva.
, LOTS of o-link
◉ Glycosphingolipids.
Answer: Sphingolipids with head groups composed of sugars are
either cerebrosides (single sugar) or globosides (two or more
sugars)
Aid in nerve conduction and signal transduction
1-7 sugars on sphingolipid
BLOOD STUFF
◉ Difference between glycosphingolipids, glycoprotiens, and
proteoglycans.
Answer: Gylcospingolipds short and attached to lipid
Gylcoprotiens: Chunky protien with short oligosaccharides attached.
Two groups: O and N linked
Proteoglycans: LONG protien chain with GAGS
Two groups: Syndeans and Glypican
SCRIPT WITH SOLUTIONS
◉ Heparan Sulfate.
Answer: GAG that inhibits coagulation
◉ Glycoconjugates.
Answer: Carbohydrates connected to protiens or lipids
◉ Proteogylcans.
Answer: A glycoconjugate found in animal cells with a LONG core
protein and has GAGS attached
Interact through electrostatic interactions
◉ Syndecans.
Answer: Single transmembrane domain and an extracellular domain
bearing 3-5 chains of heparan sulfate and chondroitin sulfate.
Core protein goes through full membrane with a COO- at the bottom.
◉ Glypican.
,Answer: A heparan sulfate proteoglycan attached to a membrane
through a glycosyl phosphatidylinositol (GPI) anchor (a lipid).
◉ What are syndecans and glypicans cleaved by?.
Answer: Syndecans: protease
Glypicans: Lipase
◉ Glycoprotiens.
Answer: Protiens with one or more short oligosaccharides
covalently attached
Help with signalling
◉ The two types of gylcoprotiens.
Answer: O-linked: Anomeric carbon linked through OH at Ser or Thr
N-linked: Anomeric carbon linked through amide nitrogen of Asn
◉ Mucins.
Answer: Glycoproteins that are primarily responsible for the
lubricating action of saliva.
, LOTS of o-link
◉ Glycosphingolipids.
Answer: Sphingolipids with head groups composed of sugars are
either cerebrosides (single sugar) or globosides (two or more
sugars)
Aid in nerve conduction and signal transduction
1-7 sugars on sphingolipid
BLOOD STUFF
◉ Difference between glycosphingolipids, glycoprotiens, and
proteoglycans.
Answer: Gylcospingolipds short and attached to lipid
Gylcoprotiens: Chunky protien with short oligosaccharides attached.
Two groups: O and N linked
Proteoglycans: LONG protien chain with GAGS
Two groups: Syndeans and Glypican
