NCLEX Pharmacology 2026
100-Question Comprehensive Mock Exam
100 ORIGINAL QUESTIONS | TIMED PRACTICE EXAM
Drug classes | safety | pharmacology review
, Exam Instructions
Suggested time: 120 minutes. Select the single best answer for each question. Mark your choices on the response line. The answer
key appears after all questions; complete the exam before checking it.
Scoring: One point per question. This is an original study simulation, not an official NCLEX examination or a prediction of
licensure-exam performance.
Content blueprint
Topic Items
Pharmacology Foundations and Pharmacokinetics 7
Medication Safety and Dosage Principles 7
Autonomic and Cholinergic Pharmacology 7
Antihypertensives and Heart Failure Drugs 7
Cardiac Rhythm, Angina and Lipid Drugs 7
Diuretics, Renal Drugs and Electrolytes 7
Anticoagulants and Hematology Drugs 7
Respiratory and Allergy Drugs 7
Antimicrobial Pharmacology 7
Diabetes and Endocrine Medications 7
Gastrointestinal Medications 6
Neurologic and Psychiatric Medications 6
Pain, Anesthesia and Sedative Drugs 6
Oncology, Immunology and Inflammation Drugs 6
Maternal, Pediatric and Emergency Medication Safety 6
NCLEX PHARMACOLOGY 2026 | ANSWER KEY EDITION 2
, Pharmacology Mock Exam
Choose one best answer for each question.
1. What is antibiotic resistance?
A. Nephrotoxicity and ototoxicity.
B. Tendon injury; other serious risks are described in product labeling.
C. The ability of microorganisms to survive or grow despite an antimicrobial.
D. Renal function and drug exposure monitoring per protocol.
Response: ______
2. What is the purpose of glucagon in severe hypoglycemia?
A. Promotes glucose uptake and storage, lowering blood glucose.
B. Current glucose, meal availability/intake, and the prescribed plan.
C. Raise blood glucose when the patient cannot safely take oral carbohydrate.
D. Rapid onset; coordinate it closely with meals.
Response: ______
3. What should a patient do before stopping an antiseizure medication?
A. Consult the prescriber; abrupt discontinuation may provoke seizures.
B. Carbidopa reduces peripheral levodopa conversion and adverse effects.
C. Take on schedule as prescribed; late doses can worsen motor symptoms.
D. Provides a dopamine precursor that can cross the blood-brain barrier.
Response: ______
4. What does a maintenance dose accomplish?
A. A comparison of toxic and therapeutic dose or concentration.
B. The lowest concentration, generally measured just before the next dose.
C. The highest concentration after a dose, measured at the drug-specific time.
D. Maintains a desired drug concentration over time.
Response: ______
5. What should be checked before administering sublingual nitroglycerin?
A. Blood pressure and recent use of PDE-5 inhibitors.
B. Prolongs cardiac repolarization and affects multiple cardiac ion channels.
C. Lungs, liver, thyroid, eyes, and cardiac rhythm as directed.
D. Transient flushing, chest pressure, dyspnea, or brief AV block.
Response: ______
6. What do proton-pump inhibitors do?
A. Suppress gastric acid secretion by inhibiting the H+/K+ ATPase.
B. Block histamine H2 receptors on gastric parietal cells.
C. Potential risks such as nutrient deficiencies or infection should be periodically reviewed.
D. Take as directed, often before a meal; follow the product instructions.
Response: ______
7. What is a common serious adverse effect of fluoroquinolones?
A. A potentially unpleasant disulfiram-like reaction; avoid alcohol as directed by labeling.
B. They can affect developing teeth and bone.
C. Separate from minerals such as calcium or iron as directed; photosensitivity may occur.
D. Tendon injury; other serious risks are described in product labeling.
Response: ______
NCLEX PHARMACOLOGY 2026 | ANSWER KEY EDITION 3
100-Question Comprehensive Mock Exam
100 ORIGINAL QUESTIONS | TIMED PRACTICE EXAM
Drug classes | safety | pharmacology review
, Exam Instructions
Suggested time: 120 minutes. Select the single best answer for each question. Mark your choices on the response line. The answer
key appears after all questions; complete the exam before checking it.
Scoring: One point per question. This is an original study simulation, not an official NCLEX examination or a prediction of
licensure-exam performance.
Content blueprint
Topic Items
Pharmacology Foundations and Pharmacokinetics 7
Medication Safety and Dosage Principles 7
Autonomic and Cholinergic Pharmacology 7
Antihypertensives and Heart Failure Drugs 7
Cardiac Rhythm, Angina and Lipid Drugs 7
Diuretics, Renal Drugs and Electrolytes 7
Anticoagulants and Hematology Drugs 7
Respiratory and Allergy Drugs 7
Antimicrobial Pharmacology 7
Diabetes and Endocrine Medications 7
Gastrointestinal Medications 6
Neurologic and Psychiatric Medications 6
Pain, Anesthesia and Sedative Drugs 6
Oncology, Immunology and Inflammation Drugs 6
Maternal, Pediatric and Emergency Medication Safety 6
NCLEX PHARMACOLOGY 2026 | ANSWER KEY EDITION 2
, Pharmacology Mock Exam
Choose one best answer for each question.
1. What is antibiotic resistance?
A. Nephrotoxicity and ototoxicity.
B. Tendon injury; other serious risks are described in product labeling.
C. The ability of microorganisms to survive or grow despite an antimicrobial.
D. Renal function and drug exposure monitoring per protocol.
Response: ______
2. What is the purpose of glucagon in severe hypoglycemia?
A. Promotes glucose uptake and storage, lowering blood glucose.
B. Current glucose, meal availability/intake, and the prescribed plan.
C. Raise blood glucose when the patient cannot safely take oral carbohydrate.
D. Rapid onset; coordinate it closely with meals.
Response: ______
3. What should a patient do before stopping an antiseizure medication?
A. Consult the prescriber; abrupt discontinuation may provoke seizures.
B. Carbidopa reduces peripheral levodopa conversion and adverse effects.
C. Take on schedule as prescribed; late doses can worsen motor symptoms.
D. Provides a dopamine precursor that can cross the blood-brain barrier.
Response: ______
4. What does a maintenance dose accomplish?
A. A comparison of toxic and therapeutic dose or concentration.
B. The lowest concentration, generally measured just before the next dose.
C. The highest concentration after a dose, measured at the drug-specific time.
D. Maintains a desired drug concentration over time.
Response: ______
5. What should be checked before administering sublingual nitroglycerin?
A. Blood pressure and recent use of PDE-5 inhibitors.
B. Prolongs cardiac repolarization and affects multiple cardiac ion channels.
C. Lungs, liver, thyroid, eyes, and cardiac rhythm as directed.
D. Transient flushing, chest pressure, dyspnea, or brief AV block.
Response: ______
6. What do proton-pump inhibitors do?
A. Suppress gastric acid secretion by inhibiting the H+/K+ ATPase.
B. Block histamine H2 receptors on gastric parietal cells.
C. Potential risks such as nutrient deficiencies or infection should be periodically reviewed.
D. Take as directed, often before a meal; follow the product instructions.
Response: ______
7. What is a common serious adverse effect of fluoroquinolones?
A. A potentially unpleasant disulfiram-like reaction; avoid alcohol as directed by labeling.
B. They can affect developing teeth and bone.
C. Separate from minerals such as calcium or iron as directed; photosensitivity may occur.
D. Tendon injury; other serious risks are described in product labeling.
Response: ______
NCLEX PHARMACOLOGY 2026 | ANSWER KEY EDITION 3
