NR547 WEEK 2 ADVANCED
PSYCHOPHARMACOLOGY EXAM
QUESTIONS WITH CORRECT ANSWERS
(LATEST ), (A+ GUARANTEE).
1. Which neurotransmitter is primarily synthesized from the amino acid tryptophan?
A. Dopamine
B. Serotonin
C. Norepinephrine
D. Glutamate
Answer: B
Conceptual Explanation: Serotonin (5-hydroxytryptamine) is synthesized from the
essential amino acid tryptophan via the enzyme tryptophan hydroxylase.
2. The rate-limiting step in the synthesis of dopamine involves which enzyme?
A. Tyrosine hydroxylase
B. Dopa decarboxylase
C. Monoamine oxidase
D. Catechol-O-methyltransferase
,Answer: A
Conceptual Explanation: Tyrosine hydroxylase is the rate-limiting enzyme that converts
L-tyrosine to L-DOPA in the catecholamine synthesis pathway.
3. Which receptor type is classified as a ligand-gated ion channel?
A. 5-HT1A
B. GABA-A
C. D2 Receptor
D. Beta-1 Adrenergic
Answer: B
Conceptual Explanation: GABA-A receptors are ionotropic receptors that function as
ligand-gated chloride channels, unlike the other options which are G-protein coupled
receptors.
4. In signal transduction, which molecule often acts as a second messenger activated by G-
protein coupled receptors?
A. Cyclic adenosine monophosphate (cAMP)
B. Chloride
C. Magnesium
D. Glycine
Answer: A
, Conceptual Explanation: cAMP is a common second messenger that transmits signals
from GPCRs to downstream effectors like protein kinase A.
5. What is the primary mechanism of action for Selective Serotonin Reuptake Inhibitors
(SSRIs)?
A. Inhibition of the SERT protein
B. Antagonism of 5-HT2A receptors
C. Inhibition of Monoamine Oxidase
D. Stimulation of serotonin release
Answer: A
Conceptual Explanation: SSRIs work by binding to and inhibiting the serotonin
transporter (SERT), preventing the reuptake of serotonin into the presynaptic neuron.
6. Which cytochrome P450 enzyme is notably inhibited by fluoxetine and paroxetine?
A. CYP2D6
B. CYP3A4
C. CYP1A2
D. CYP2C19
Answer: A
PSYCHOPHARMACOLOGY EXAM
QUESTIONS WITH CORRECT ANSWERS
(LATEST ), (A+ GUARANTEE).
1. Which neurotransmitter is primarily synthesized from the amino acid tryptophan?
A. Dopamine
B. Serotonin
C. Norepinephrine
D. Glutamate
Answer: B
Conceptual Explanation: Serotonin (5-hydroxytryptamine) is synthesized from the
essential amino acid tryptophan via the enzyme tryptophan hydroxylase.
2. The rate-limiting step in the synthesis of dopamine involves which enzyme?
A. Tyrosine hydroxylase
B. Dopa decarboxylase
C. Monoamine oxidase
D. Catechol-O-methyltransferase
,Answer: A
Conceptual Explanation: Tyrosine hydroxylase is the rate-limiting enzyme that converts
L-tyrosine to L-DOPA in the catecholamine synthesis pathway.
3. Which receptor type is classified as a ligand-gated ion channel?
A. 5-HT1A
B. GABA-A
C. D2 Receptor
D. Beta-1 Adrenergic
Answer: B
Conceptual Explanation: GABA-A receptors are ionotropic receptors that function as
ligand-gated chloride channels, unlike the other options which are G-protein coupled
receptors.
4. In signal transduction, which molecule often acts as a second messenger activated by G-
protein coupled receptors?
A. Cyclic adenosine monophosphate (cAMP)
B. Chloride
C. Magnesium
D. Glycine
Answer: A
, Conceptual Explanation: cAMP is a common second messenger that transmits signals
from GPCRs to downstream effectors like protein kinase A.
5. What is the primary mechanism of action for Selective Serotonin Reuptake Inhibitors
(SSRIs)?
A. Inhibition of the SERT protein
B. Antagonism of 5-HT2A receptors
C. Inhibition of Monoamine Oxidase
D. Stimulation of serotonin release
Answer: A
Conceptual Explanation: SSRIs work by binding to and inhibiting the serotonin
transporter (SERT), preventing the reuptake of serotonin into the presynaptic neuron.
6. Which cytochrome P450 enzyme is notably inhibited by fluoxetine and paroxetine?
A. CYP2D6
B. CYP3A4
C. CYP1A2
D. CYP2C19
Answer: A
