NR507 Advanced Pathophysiology Mid-Term Test with all Correct &
100% Verified Answers |Latest Version |Already Graded A+
1. Hypersensitivit Type 1: Allergic reaction, Mediated by IgE, Inflammation due to mast cell
y:
degran-ulation
Type 1
Local symptoms:
-itching
-rash
Systemic symptoms:
-wheezing
Most dangerous = anaphylactic reaction
systemic response of hypotension, severe
bronchoconstriction Main treatment: epinephrine
reverses the ettects
2. Hypersensitivit
y: Type 2: Cytotoxic reaction; tissue specific (ex: thyroid tissue)
Type 2
Macrophages are the primary ettectors cells involved
Can cause tissue damage or alter function
Grave's disease (hyperthyroidism) - example of altering thyroid function,
but does not destroy thyroid tissue
Incompatible blood type- example of cell/tissue damage that occurs;
severe trans-fusion reaction occurs and the transfused erythrocytes are
destroyed by aggluti-nation or complement-mediated lysis.
3. Type 1 Type 1
Hypersen- Hypersensitivity
sitivity VS.
Organ Specific
Type 2
Antibody binds to the antigen on the cell surface
Hypersensitivit
y Type 2
Hypersensitivity Not
1/
27
, NR507 Advanced Pathophysiology Mid-Term Test with all Correct &
100% Verified Answers |Latest Version |Already Graded A+
O
r
g
a
n
S
p
e
c
i
f
i
c
Antibody binds to the
soluble antigen outside the
cell surface that was
released into the blood or
body fluids, and the
complex is then deposited
in the tissues
2/
27
, NR507 Advanced Pathophysiology Mid-Term Test with all Correct &
100% Verified Answers |Latest Version |Already Graded A+
4. Hypersensitivity: Rheumatoid arthritis: Antigen/antibodies are deposited in the joints
Type 3 - Examples
Systemic Lupus Erythematosus (SLE)- very closely related to
autoimmunity- anti-gen/antibodies deposit in organs that cause tissue
damage
5. Hypersensitivi Delayed response
ty:
Type 4 Does not involve antigen/antibody complexes like Types 1, 2
and 3 Is T-cell mediated
6. Differentiating Type 1: Immediate hypersensitivity reactions, termed atopic dermatitis,
are usually
Between the
characterized by widely distributed lesions
Rash of a
Type 1 vs.
Type 4: Contact dermatitis (delayed hypersensitivity) consists of lesions only
Type 4
at the site of contact with the allergen
Reaction:
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex would be poison
ivy
7. Treatment of
Type 4 Rash A non-severe case of contact dermatitis would be treated with topical
corticos-teroid.
Why not epinephrine or antihistamines?
-Epinephrine is for emergent Type 1 anaphylactic reactions.
Antihistamines act on the H1 receptors. Type 4 does not involve
mast cells and H1 receptors.
Antibiotics not appropriate since not an infection
3/
27
100% Verified Answers |Latest Version |Already Graded A+
1. Hypersensitivit Type 1: Allergic reaction, Mediated by IgE, Inflammation due to mast cell
y:
degran-ulation
Type 1
Local symptoms:
-itching
-rash
Systemic symptoms:
-wheezing
Most dangerous = anaphylactic reaction
systemic response of hypotension, severe
bronchoconstriction Main treatment: epinephrine
reverses the ettects
2. Hypersensitivit
y: Type 2: Cytotoxic reaction; tissue specific (ex: thyroid tissue)
Type 2
Macrophages are the primary ettectors cells involved
Can cause tissue damage or alter function
Grave's disease (hyperthyroidism) - example of altering thyroid function,
but does not destroy thyroid tissue
Incompatible blood type- example of cell/tissue damage that occurs;
severe trans-fusion reaction occurs and the transfused erythrocytes are
destroyed by aggluti-nation or complement-mediated lysis.
3. Type 1 Type 1
Hypersen- Hypersensitivity
sitivity VS.
Organ Specific
Type 2
Antibody binds to the antigen on the cell surface
Hypersensitivit
y Type 2
Hypersensitivity Not
1/
27
, NR507 Advanced Pathophysiology Mid-Term Test with all Correct &
100% Verified Answers |Latest Version |Already Graded A+
O
r
g
a
n
S
p
e
c
i
f
i
c
Antibody binds to the
soluble antigen outside the
cell surface that was
released into the blood or
body fluids, and the
complex is then deposited
in the tissues
2/
27
, NR507 Advanced Pathophysiology Mid-Term Test with all Correct &
100% Verified Answers |Latest Version |Already Graded A+
4. Hypersensitivity: Rheumatoid arthritis: Antigen/antibodies are deposited in the joints
Type 3 - Examples
Systemic Lupus Erythematosus (SLE)- very closely related to
autoimmunity- anti-gen/antibodies deposit in organs that cause tissue
damage
5. Hypersensitivi Delayed response
ty:
Type 4 Does not involve antigen/antibody complexes like Types 1, 2
and 3 Is T-cell mediated
6. Differentiating Type 1: Immediate hypersensitivity reactions, termed atopic dermatitis,
are usually
Between the
characterized by widely distributed lesions
Rash of a
Type 1 vs.
Type 4: Contact dermatitis (delayed hypersensitivity) consists of lesions only
Type 4
at the site of contact with the allergen
Reaction:
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex would be poison
ivy
7. Treatment of
Type 4 Rash A non-severe case of contact dermatitis would be treated with topical
corticos-teroid.
Why not epinephrine or antihistamines?
-Epinephrine is for emergent Type 1 anaphylactic reactions.
Antihistamines act on the H1 receptors. Type 4 does not involve
mast cells and H1 receptors.
Antibiotics not appropriate since not an infection
3/
27
