INBDE- Booster Additional Concepts –
Pharmacology Final Exam Fully Solved.
6 NSAIDs - Answer 1) Aspirin: COX1 & COX2 irreversible, impacts GI
2) Ibuprofen: COX1 & COX2 reversible, impacts kidney
3) Naproxen: COX1 & COX2 reversible
4) Ketorolac: COX1 & COX2 reversible
5) Celecoxib: COX2
6) Meloxicam: COX2
3 Overdose/Addiction Drugs - Answer Naloxone: competitive opioid antagonist [may require
multiple doses since shorter half-life]
Naltrexone: antagonist that treats addiction
Methadone: synthetic opioid agonist that can be used for pain relief and opioid addiction
4 NSAID Interactions with Other Drugs - Answer Lithium - increases lithium toxicity
Hypotensives - decreases effect of hypotensive
Anticoagulants - increases risk of bleeding
-Methotrexate - Increases methotrexate toxicity
4 Conditions to Avoid with M Agonist Drugs - Answer o 1) Asthma/COPD: airflow obstruction
to the lungs
o 2) Peptic Ulcers: cause an increase in secretion of gastric acid
o 3) Coronary Heart Disease: worsen cases of coronary heart disease
4) Hyperthyroidism : depress cardiac system cuasing the body to compensate and release
epinephrine
Prilocarpine - Answer Direct acting M Agonist used to stimulate saliva or eye drops to constrict
pupils and reduce pressure
Indirect Acting M Agonist Drugs - Answer I. Physostigmine & Neostigmine: reversible inhibit
cholinesterase
II. Insecticides & Nerve Gases: irreversibly inhibit cholinesterase
M Agonist/Ganglionic Blockers - Answer I. Scopolamine: helpfulin reduction of saliva
II. Atropine: helpful in reduction of saliva
Pharmacology Final Exam Fully Solved.
6 NSAIDs - Answer 1) Aspirin: COX1 & COX2 irreversible, impacts GI
2) Ibuprofen: COX1 & COX2 reversible, impacts kidney
3) Naproxen: COX1 & COX2 reversible
4) Ketorolac: COX1 & COX2 reversible
5) Celecoxib: COX2
6) Meloxicam: COX2
3 Overdose/Addiction Drugs - Answer Naloxone: competitive opioid antagonist [may require
multiple doses since shorter half-life]
Naltrexone: antagonist that treats addiction
Methadone: synthetic opioid agonist that can be used for pain relief and opioid addiction
4 NSAID Interactions with Other Drugs - Answer Lithium - increases lithium toxicity
Hypotensives - decreases effect of hypotensive
Anticoagulants - increases risk of bleeding
-Methotrexate - Increases methotrexate toxicity
4 Conditions to Avoid with M Agonist Drugs - Answer o 1) Asthma/COPD: airflow obstruction
to the lungs
o 2) Peptic Ulcers: cause an increase in secretion of gastric acid
o 3) Coronary Heart Disease: worsen cases of coronary heart disease
4) Hyperthyroidism : depress cardiac system cuasing the body to compensate and release
epinephrine
Prilocarpine - Answer Direct acting M Agonist used to stimulate saliva or eye drops to constrict
pupils and reduce pressure
Indirect Acting M Agonist Drugs - Answer I. Physostigmine & Neostigmine: reversible inhibit
cholinesterase
II. Insecticides & Nerve Gases: irreversibly inhibit cholinesterase
M Agonist/Ganglionic Blockers - Answer I. Scopolamine: helpfulin reduction of saliva
II. Atropine: helpful in reduction of saliva
