The Renin Angiotensin Aldosterone System Questions with Correct
Answers (Grade A+)
Question 1: Explain the function of the renin-an- giotensin-aldosterone system (RAAS) in regulating
blood pressure and flu- id balance, and describe the specif- ic role of renin, angiotensinogen, an-
giotensin I, angiotensin II, and aldos- terone within the pathway
Answer: RAAS is the major regulator of renal sodium ex- cretion and blood pressure. Dysregulation leads
to hypertension
Question 2: Describe the specific role of renin within the pathway
Answer: It hydrolyzes angiotensinogen to angiotensin I
Question 3: Describe the specific role of an- giotensinogen within the pathway
Answer: It is constitutively synthesized by the liver. It is not active. It is a renin substrate
Question 4: Describe the specific role of an- giotensin I within the pathway
Answer: It is a product of renin's action on angiotensinogen. It has weak action with mild vasoconstrictor
prop- erties. It is the precursor for angiotensin II
Question 5: Describe the specific role of an- giotensin II within the pathway
Answer: It is the product of angiotensin-converting en- zyme's action of angiotensin I. It has many actions,
but only exists in blood for 1-2 minutes. It is in- activated by blood and tissue enzymes called an-
giotensinases
Question 6: Describe the specific role of aldos- terone within the pathway
Answer: It triggers Na+ reabsorption (increase), K+ excre- tion (decrease), and is also involved in acid-base
balance
Question 7: List two classes of mediations that tar- -Angiotensin get the RAAS.
Answer: converting enzyme inhibitors (ACEi) -Aldosterone receptor blockers (ARBs)
Question 8: Name the three main cell types that make up the juxtaglomerular appara- tus.
Answer: -Juxtaglomerular cells (granular cells) -Macula densa -Extraglomerular mesangial cells (Lacis
cells)
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Answers (Grade A+)
Question 1: Explain the function of the renin-an- giotensin-aldosterone system (RAAS) in regulating
blood pressure and flu- id balance, and describe the specif- ic role of renin, angiotensinogen, an-
giotensin I, angiotensin II, and aldos- terone within the pathway
Answer: RAAS is the major regulator of renal sodium ex- cretion and blood pressure. Dysregulation leads
to hypertension
Question 2: Describe the specific role of renin within the pathway
Answer: It hydrolyzes angiotensinogen to angiotensin I
Question 3: Describe the specific role of an- giotensinogen within the pathway
Answer: It is constitutively synthesized by the liver. It is not active. It is a renin substrate
Question 4: Describe the specific role of an- giotensin I within the pathway
Answer: It is a product of renin's action on angiotensinogen. It has weak action with mild vasoconstrictor
prop- erties. It is the precursor for angiotensin II
Question 5: Describe the specific role of an- giotensin II within the pathway
Answer: It is the product of angiotensin-converting en- zyme's action of angiotensin I. It has many actions,
but only exists in blood for 1-2 minutes. It is in- activated by blood and tissue enzymes called an-
giotensinases
Question 6: Describe the specific role of aldos- terone within the pathway
Answer: It triggers Na+ reabsorption (increase), K+ excre- tion (decrease), and is also involved in acid-base
balance
Question 7: List two classes of mediations that tar- -Angiotensin get the RAAS.
Answer: converting enzyme inhibitors (ACEi) -Aldosterone receptor blockers (ARBs)
Question 8: Name the three main cell types that make up the juxtaglomerular appara- tus.
Answer: -Juxtaglomerular cells (granular cells) -Macula densa -Extraglomerular mesangial cells (Lacis
cells)
Page 1
