NR566 Final (Advanced Pharmacology for Care of the Family)
Questions with Verified Answers (Correct Update)
Question 1: Anti-Androgens
Answer: Finasteride (Propecia) Leuprolide (Eligard, Lupron, Lupron Depot) Spironolactone (Aldactone)
Question 2: Finasteride (Propecia, Proscar)
Answer: blocks conversion of testosterone to dihydrotesterone Used to tx:
-BPH
-male pattern baldness 3 months of therapy need to see benefits Stopping, reverses effect w/in 12
months Adverse side effects:
- Decreased libido
-Impotence
Question 3: dutasteride (Avodart)
Answer: 5-alpha reductase inhibitor used to tx: BPH Can stay in serum up to 6 mon after discontinuing
can be absorbed through skin pregnant woman shouldn't handle capsules (fetal anomaly in male fetus)
Adverse Effects decreased libido Impotence
Question 4: Leuprolide Acetate (Lupron)
Answer: Luteinizing hormone - releasing agonist create reversible:
-orchiectomy state
-oophorectomy state Used to tx:
- advanced prostatic cancer
- Management of endometriosis
- Uterine fibroids
- polycystic ovarian disease
- central precocious puberty in peds
Question 5: Flutamide (Eulexin, Euflex)
Answer: Truly non-steroidal agent Used to tx:
-Advanced prostate cancer
-female androgen excess syndrome Adverse Effects in males
- gynecomastia
-reversible liver toxicity Black Box Warning
-hepatic failure
-hepatic encephalopathy Basline/monthly liver function test for 1st 4 months
Page 1
, Question 6: Spironolactone (Aldactone)
Answer: aldosterone antagonist potassium sparing diuretic used for tx:
-female hirsutism (abnormal growth of hair)
-acne
-relief of PMS/PMDD symptoms (25-50 mg/d) Adverse reactions
- dose related + reversible when discont.
-GI upset
-Drowsiness
-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions
- Urticaria Black Box Warning Tumorigenicity in animals Should not be used during pregnancy
Question 7: Androgen
Answer: Testosterone most important adrogen in humans levels remain stable at 55yr 70 yrs men
decrease in
-strength, libido, muscle mass
Question 8: Transdermal application of testosterone
Answer: Patch + gel can be applied to intact nonscrotal skin once daily not for use in woman men cannot
have skin contact with pregnant woman or children Men need to wash hands after application + allow
skin to dry
Question 9: Testopel
Answer: Subcu Pellet produces testosterone for 3-6 months
Question 10: Contraindications for Testosterone
Answer: Male breast cancer prostate cancer Pregnancy (X category) Lactation
Question 11: Complications of Testosterone
Answer: - Edema w/or w/out congestive heart failure (use caution in pts w/ preexisting cardiac, renal, or
hepatic disease) Increased risk for
-prostatic hypertrophy
-prostatic hyperplasia
-prostatic carcinoma Hypogonadal men might experience sleep apnea This risk increases in men
w/obesity or chronic lung disease.
Question 12: Refer to endocrinologist
Answer: stimulating growth in boys with delayed puberty aging men to increase strength + muscle mass
Page 2
Questions with Verified Answers (Correct Update)
Question 1: Anti-Androgens
Answer: Finasteride (Propecia) Leuprolide (Eligard, Lupron, Lupron Depot) Spironolactone (Aldactone)
Question 2: Finasteride (Propecia, Proscar)
Answer: blocks conversion of testosterone to dihydrotesterone Used to tx:
-BPH
-male pattern baldness 3 months of therapy need to see benefits Stopping, reverses effect w/in 12
months Adverse side effects:
- Decreased libido
-Impotence
Question 3: dutasteride (Avodart)
Answer: 5-alpha reductase inhibitor used to tx: BPH Can stay in serum up to 6 mon after discontinuing
can be absorbed through skin pregnant woman shouldn't handle capsules (fetal anomaly in male fetus)
Adverse Effects decreased libido Impotence
Question 4: Leuprolide Acetate (Lupron)
Answer: Luteinizing hormone - releasing agonist create reversible:
-orchiectomy state
-oophorectomy state Used to tx:
- advanced prostatic cancer
- Management of endometriosis
- Uterine fibroids
- polycystic ovarian disease
- central precocious puberty in peds
Question 5: Flutamide (Eulexin, Euflex)
Answer: Truly non-steroidal agent Used to tx:
-Advanced prostate cancer
-female androgen excess syndrome Adverse Effects in males
- gynecomastia
-reversible liver toxicity Black Box Warning
-hepatic failure
-hepatic encephalopathy Basline/monthly liver function test for 1st 4 months
Page 1
, Question 6: Spironolactone (Aldactone)
Answer: aldosterone antagonist potassium sparing diuretic used for tx:
-female hirsutism (abnormal growth of hair)
-acne
-relief of PMS/PMDD symptoms (25-50 mg/d) Adverse reactions
- dose related + reversible when discont.
-GI upset
-Drowsiness
-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions
- Urticaria Black Box Warning Tumorigenicity in animals Should not be used during pregnancy
Question 7: Androgen
Answer: Testosterone most important adrogen in humans levels remain stable at 55yr 70 yrs men
decrease in
-strength, libido, muscle mass
Question 8: Transdermal application of testosterone
Answer: Patch + gel can be applied to intact nonscrotal skin once daily not for use in woman men cannot
have skin contact with pregnant woman or children Men need to wash hands after application + allow
skin to dry
Question 9: Testopel
Answer: Subcu Pellet produces testosterone for 3-6 months
Question 10: Contraindications for Testosterone
Answer: Male breast cancer prostate cancer Pregnancy (X category) Lactation
Question 11: Complications of Testosterone
Answer: - Edema w/or w/out congestive heart failure (use caution in pts w/ preexisting cardiac, renal, or
hepatic disease) Increased risk for
-prostatic hypertrophy
-prostatic hyperplasia
-prostatic carcinoma Hypogonadal men might experience sleep apnea This risk increases in men
w/obesity or chronic lung disease.
Question 12: Refer to endocrinologist
Answer: stimulating growth in boys with delayed puberty aging men to increase strength + muscle mass
Page 2
