INBDE - Pharm - Pharmacokinetics and
Pharmacodynamics Study Guide
pharmacodynamics - Answer what the drug does to the body
almost all drug targets are - Answer proteins
agonist - Answer mimics the effects of an endogenous agonist molecule
full vs partial agonist - Answer full - can produce 100% of the desired effect
partial - can't "
antagonist (two types) - Answer competitive - competes for the same binding site
noncompetitive - binds to a different non overlapping binding site but still prevents binding
inverse agonist - Answer inhibits the basal activity of a receptor in the absence of the normal
agonist
(binds to a special kind of receptor that is active at rest in order to inhibit its basal activity)
Type I dose response curve - Answer x axis - dose
y-axis - response
usually logarithmic, can be hyperbolic
intrinsic activity / emax of a drug - Answer full agonist - 1
partial agonist - 0 to 1
antagonist - 0
inverse agonist - negative number
efficacy - Answer effect of a drug as a function of binding
affinity - Answer attractiveness of a drug to its receptor
the lower the dissociation constant the _____ the affinity - Answer higher
, potency - Answer power of a drug at a specific concentration
usually measured by the effective concentration of the drug leading to half its maximal effect
(EC50)
competitive antagonist shifts agonist curve - Answer right
noncompetitive antagonist shifts the agonist curve - Answer downq
type II dose response curve - Answer x axis - dose
y axis - number of subjects responding to a drug
for a type II dose response curve what different curves can you measure - Answer therapeutic,
toxic, lethal
ED50 - Answer 50 percent experience effective treatment
TD50 - Answer 50 percent have toxic side effects
LD50 - Answer 50 percent have died
therapeutic index - Answer animal studies: LD50/ED50
human studeis: TD50/ED50
larger therapeutic index - safer drug
additive effect - Answer combining drugs combines their individual degrees of effect
antagonistic effect - Answer combining drugs causes a lesser effect than one drug alone
types of antagonistic effects - Answer chemical - drug binds another drug
receptor - competition for a receptor between two drugs
pharmacokinetic - one drug affects the PK of another
physiologic - two drugs produce opposing effects on the same tissue
Pharmacodynamics Study Guide
pharmacodynamics - Answer what the drug does to the body
almost all drug targets are - Answer proteins
agonist - Answer mimics the effects of an endogenous agonist molecule
full vs partial agonist - Answer full - can produce 100% of the desired effect
partial - can't "
antagonist (two types) - Answer competitive - competes for the same binding site
noncompetitive - binds to a different non overlapping binding site but still prevents binding
inverse agonist - Answer inhibits the basal activity of a receptor in the absence of the normal
agonist
(binds to a special kind of receptor that is active at rest in order to inhibit its basal activity)
Type I dose response curve - Answer x axis - dose
y-axis - response
usually logarithmic, can be hyperbolic
intrinsic activity / emax of a drug - Answer full agonist - 1
partial agonist - 0 to 1
antagonist - 0
inverse agonist - negative number
efficacy - Answer effect of a drug as a function of binding
affinity - Answer attractiveness of a drug to its receptor
the lower the dissociation constant the _____ the affinity - Answer higher
, potency - Answer power of a drug at a specific concentration
usually measured by the effective concentration of the drug leading to half its maximal effect
(EC50)
competitive antagonist shifts agonist curve - Answer right
noncompetitive antagonist shifts the agonist curve - Answer downq
type II dose response curve - Answer x axis - dose
y axis - number of subjects responding to a drug
for a type II dose response curve what different curves can you measure - Answer therapeutic,
toxic, lethal
ED50 - Answer 50 percent experience effective treatment
TD50 - Answer 50 percent have toxic side effects
LD50 - Answer 50 percent have died
therapeutic index - Answer animal studies: LD50/ED50
human studeis: TD50/ED50
larger therapeutic index - safer drug
additive effect - Answer combining drugs combines their individual degrees of effect
antagonistic effect - Answer combining drugs causes a lesser effect than one drug alone
types of antagonistic effects - Answer chemical - drug binds another drug
receptor - competition for a receptor between two drugs
pharmacokinetic - one drug affects the PK of another
physiologic - two drugs produce opposing effects on the same tissue
