NR 566 WEEK 2: advanced pharmacology for care of family: ABX
Questions with Verified Answers (Correct Update)
Question 1: Penicillin is also known as a abx: disrupts cell wall, like all beta lactams
Answer: beta lactam
Question 2: Penicillins weaken cell wall, causing bacteria to take up hella water ----> bursts ,
Penicillins weaken cell wall by inhibiting an enzyme that strengthens bacterial cell wall
Answer: bacterial transpeptidase
Question 3: Penicillins are only active against bacteria that are undergoing and
Answer: growth division
Question 4: bacterial resistance in penicillins is determined by 3 factors: 1. of penicillins by
bacterial enzymes 2. production of penicillin binding proteins that have a affinity for penicillins
3. inability of to reach their targets
Answer: inactivation low penicllins
Question 5: describe gram negative penicillin activity: only certain penicillins like are able to
cross it to reach penicillin binding protein on cytoplasmic membrane there are 3 layers:
1.cytoplasmic membrane 2. cell wall 3. additional outer membrane
Answer: ampicillin thin
Question 6: the main difference in Pen G and Pen V is Pen _ is stable in the stomach, Pen _ is not.
Answer: acid stability V G
Question 7: Pen _ can be given PO, with meals
Answer: V
Question 8: Cephalosporins are , they bind to penicillin binding proteins, disrupt cell wall
synthesis, and activate , --> cell death
Answer: bactericidal autolysins
Question 9: Cephalosporins are most effective against cells undergoing and
Answer: growth division
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, Question 10: and induce alcohol intolerance if pt were to drink alcohol while on either abx, they
could have a
-like reaction, dangerous! s/s: HoTN, , HA
Answer: cefazolin; cefotetan disulfram; palpitations
Question 11: (cephalosporins) , , and can increase bleeding because they have a side chain that
interfere with vitamin metabolism stopping factor from forming
Answer: Cefotetan, cefazolin, ceftriaxone vitamin K clotting be careful using meds with other drugs that
promote bleeding ex: warfarin, digoxin, NSAIDs, antiplatelets
Question 12: The nucleus of the cephalosporins bacteria has , which is required for antibacterial
activity
Answer: beta lactam
Question 13: Carbapenem is a antibiotic that binds to two , cell wall --> cell death
Answer: beta lactam PBPs (penicillin binding proteins) weakening
Question 14: list 3 meds under Carbapenems: 1. i 2. m 3. e
Answer: imipenem meropenem ertapenem
Question 15: only use when pt can't be treated with a more narrow spectrum abx can only be
given via , not well absorbed in GI tract
Answer: carbapenems IV can ettectively penetrate gram negative cell envelope
Question 16: decrease in pts with renal impairment
Answer: carbapenems
Question 17: Carbapenems are excreted renally, but when given alone it is deactivated by , an
enzyme in kidneys to increase urinary elimination of , the abx is given with a dipeptidase
inhibitor
Answer: dipeptidase carbapenems cilastin
Question 18: is the most used abx, often used to tx , C. diff and serious infections in pts allergic to
penicillin
Answer: vancomycin MRSA
Question 19: Vancomycin cell wall synthesis ---> cell death
Answer: inhibits
Page 2
Questions with Verified Answers (Correct Update)
Question 1: Penicillin is also known as a abx: disrupts cell wall, like all beta lactams
Answer: beta lactam
Question 2: Penicillins weaken cell wall, causing bacteria to take up hella water ----> bursts ,
Penicillins weaken cell wall by inhibiting an enzyme that strengthens bacterial cell wall
Answer: bacterial transpeptidase
Question 3: Penicillins are only active against bacteria that are undergoing and
Answer: growth division
Question 4: bacterial resistance in penicillins is determined by 3 factors: 1. of penicillins by
bacterial enzymes 2. production of penicillin binding proteins that have a affinity for penicillins
3. inability of to reach their targets
Answer: inactivation low penicllins
Question 5: describe gram negative penicillin activity: only certain penicillins like are able to
cross it to reach penicillin binding protein on cytoplasmic membrane there are 3 layers:
1.cytoplasmic membrane 2. cell wall 3. additional outer membrane
Answer: ampicillin thin
Question 6: the main difference in Pen G and Pen V is Pen _ is stable in the stomach, Pen _ is not.
Answer: acid stability V G
Question 7: Pen _ can be given PO, with meals
Answer: V
Question 8: Cephalosporins are , they bind to penicillin binding proteins, disrupt cell wall
synthesis, and activate , --> cell death
Answer: bactericidal autolysins
Question 9: Cephalosporins are most effective against cells undergoing and
Answer: growth division
Page 1
, Question 10: and induce alcohol intolerance if pt were to drink alcohol while on either abx, they
could have a
-like reaction, dangerous! s/s: HoTN, , HA
Answer: cefazolin; cefotetan disulfram; palpitations
Question 11: (cephalosporins) , , and can increase bleeding because they have a side chain that
interfere with vitamin metabolism stopping factor from forming
Answer: Cefotetan, cefazolin, ceftriaxone vitamin K clotting be careful using meds with other drugs that
promote bleeding ex: warfarin, digoxin, NSAIDs, antiplatelets
Question 12: The nucleus of the cephalosporins bacteria has , which is required for antibacterial
activity
Answer: beta lactam
Question 13: Carbapenem is a antibiotic that binds to two , cell wall --> cell death
Answer: beta lactam PBPs (penicillin binding proteins) weakening
Question 14: list 3 meds under Carbapenems: 1. i 2. m 3. e
Answer: imipenem meropenem ertapenem
Question 15: only use when pt can't be treated with a more narrow spectrum abx can only be
given via , not well absorbed in GI tract
Answer: carbapenems IV can ettectively penetrate gram negative cell envelope
Question 16: decrease in pts with renal impairment
Answer: carbapenems
Question 17: Carbapenems are excreted renally, but when given alone it is deactivated by , an
enzyme in kidneys to increase urinary elimination of , the abx is given with a dipeptidase
inhibitor
Answer: dipeptidase carbapenems cilastin
Question 18: is the most used abx, often used to tx , C. diff and serious infections in pts allergic to
penicillin
Answer: vancomycin MRSA
Question 19: Vancomycin cell wall synthesis ---> cell death
Answer: inhibits
Page 2
