ATI RN Pharmacology 2026 Exam Prep: 100
Original Practice Questions with Answers
and Rationales Covering Pharmacokinetics,
Medication Safety, Cardiovascular,
Endocrine, Infectious Disease, CNS,
Respiratory, GI, Calculations, and NGN-
Style Clinical Judgment for Level 3 Pas
PART 1: Questions 1–25
Topics: Pharmacokinetics, Medication
Safety, Dosage Calculation, Autonomic
Drugs
1. A nurse is preparing to administer a
medication and notes the client's name
,band is missing. Which action should the
nurse take?
A. Ask the client to state their name and
birth date
B. Administer the medication after
confirming with the roommate
C. Obtain a new identification band before
administering the medication
D. Check the medication administration
record (MAR) against the room number
☑VERIFIED ANSWERS: C
Rationale: The nurse must verify identity
using two identifiers from an approved
source (typically the ID band). If the band is
missing, a new one must be applied before
administration. Asking the client alone,
,using room numbers, or relying on others is
not acceptable verification.
2. A nurse is reviewing the concept of first-
pass effect. Which route is most affected?
A. Intravenous
B. Sublingual
C. Oral
D. Topical
☑VERIFIED ANSWERS: C
Rationale: Orally administered drugs are
absorbed in the GI tract and travel through
the portal vein to the liver, where a portion
is metabolized before reaching systemic
circulation. IV, sublingual, and topical routes
bypass this effect.
, 3. A nurse is calculating a dose. The order
reads: Administer 0.5 g of a medication.
The available tablet is 250 mg. How many
tablets should the nurse administer?
A. 0.5 tablet
B. 1 tablet
C. 2 tablets
D. 4 tablets
☑VERIFIED ANSWERS: C
Rationale: Convert grams to milligrams: 0.5
g = 500 mg. Then 500 mg ÷ 250 mg = 2
tablets.
4. Which assessment finding indicates a
client is experiencing an adverse effect of a
Original Practice Questions with Answers
and Rationales Covering Pharmacokinetics,
Medication Safety, Cardiovascular,
Endocrine, Infectious Disease, CNS,
Respiratory, GI, Calculations, and NGN-
Style Clinical Judgment for Level 3 Pas
PART 1: Questions 1–25
Topics: Pharmacokinetics, Medication
Safety, Dosage Calculation, Autonomic
Drugs
1. A nurse is preparing to administer a
medication and notes the client's name
,band is missing. Which action should the
nurse take?
A. Ask the client to state their name and
birth date
B. Administer the medication after
confirming with the roommate
C. Obtain a new identification band before
administering the medication
D. Check the medication administration
record (MAR) against the room number
☑VERIFIED ANSWERS: C
Rationale: The nurse must verify identity
using two identifiers from an approved
source (typically the ID band). If the band is
missing, a new one must be applied before
administration. Asking the client alone,
,using room numbers, or relying on others is
not acceptable verification.
2. A nurse is reviewing the concept of first-
pass effect. Which route is most affected?
A. Intravenous
B. Sublingual
C. Oral
D. Topical
☑VERIFIED ANSWERS: C
Rationale: Orally administered drugs are
absorbed in the GI tract and travel through
the portal vein to the liver, where a portion
is metabolized before reaching systemic
circulation. IV, sublingual, and topical routes
bypass this effect.
, 3. A nurse is calculating a dose. The order
reads: Administer 0.5 g of a medication.
The available tablet is 250 mg. How many
tablets should the nurse administer?
A. 0.5 tablet
B. 1 tablet
C. 2 tablets
D. 4 tablets
☑VERIFIED ANSWERS: C
Rationale: Convert grams to milligrams: 0.5
g = 500 mg. Then 500 mg ÷ 250 mg = 2
tablets.
4. Which assessment finding indicates a
client is experiencing an adverse effect of a
