MICR 3230 Final Exam | UPDATED Questions with 100% Verified
Answers
Question:
T & B cells use what to recognize an antigen?
Answer:
Surface molecules
Question:
B cell receptors can recognize:
Answer:
A whole antigen
Question:
T cell receptors can recognize:
Answer:
Antigen fragments that are displayed on the surface of other cells
Question:
Antigen fragments are held within:
Answer:
The binding groove of a cell surface protein called the MHC molecule
Question:
MHCs act as:
Answer:
Cell surface vessel for holding & displaying fragments of antigen so T cells can engage
with this molecular complex via their TCRs
Question:
There are ______ for most MHC genes:
Answer:
,Many alleles
Specific MHC allele inheritance plays a role in determining an individual's susceptibility to
disease
Question:
What are the 2 main types of MHC molecules?
Answer:
MHC Class I
MHC Class II
Question:
MHC class I:
Answer:
Classification of self
Present on all nucleated cells in the body (except RBCs)
Specialize in presenting antigen that originates from the cytosol
Ass. with T cytotoxic cell
Question:
MHC class II:
Answer:
Present mostly on APCs (macrophages, B cells, DCs)
Specialize in presenting antigen from extracellular spaces that have been engulfed by
APCs
Ass. with T helper cell
Question:
Mice VERSUS humans:
Answer:
H-2 complex VERSUS HLA complex
Question:
RR =
Answer:
,(frequency of allele+/allele- in diseased population) /
(frequency of allele+/allele- in general population)
Question:
RR = 1 means:
Answer:
No effect
Question:
MHC class I -
Is present on:
Answer:
All nucleated cells except for RBCs
Question:
MHC class I -
Has how many chains?
Answer:
2 chains
Alpha + beta 2 microglobulin (alpha, alpha, & beta)
Question:
MHC class I -
Info about the chains:
Answer:
Alpha chain coded on chromosome 6
Beta chain coded on chromosome 15
Beta 2 microglobulin acts as stabilizer
Alpha & alpha form cleft region that binds 8-10 AA long peptide fragment from an
antigen
Beta sheet forms the floor of the cleft
2 alpha helices form the walls
Question:
, MHC class I -
Alpha vs. beta chain encoding:
Answer:
Only alpha chain encoded in the MHC, beta joins separately
Question:
MHC class I -
Presents peptide to:
Answer:
CD8+ T cells (T cytotoxic)
Question:
MHC class I -
Responsible for:
Answer:
Graft rejection & clearance of ENDOGENOUS antigens (tumour, pathogen infected cells,
virus infected cells)
Question:
MHC class I -
What helps to anchor the peptide in the groove?
Answer:
Some AAs
Other AAs interact with TCR
Question:
MHC class II -
Is present on:
Answer:
APCs (B cells, macrophages, DCs)
Question:
MHC class II -
Responsible for:
Answers
Question:
T & B cells use what to recognize an antigen?
Answer:
Surface molecules
Question:
B cell receptors can recognize:
Answer:
A whole antigen
Question:
T cell receptors can recognize:
Answer:
Antigen fragments that are displayed on the surface of other cells
Question:
Antigen fragments are held within:
Answer:
The binding groove of a cell surface protein called the MHC molecule
Question:
MHCs act as:
Answer:
Cell surface vessel for holding & displaying fragments of antigen so T cells can engage
with this molecular complex via their TCRs
Question:
There are ______ for most MHC genes:
Answer:
,Many alleles
Specific MHC allele inheritance plays a role in determining an individual's susceptibility to
disease
Question:
What are the 2 main types of MHC molecules?
Answer:
MHC Class I
MHC Class II
Question:
MHC class I:
Answer:
Classification of self
Present on all nucleated cells in the body (except RBCs)
Specialize in presenting antigen that originates from the cytosol
Ass. with T cytotoxic cell
Question:
MHC class II:
Answer:
Present mostly on APCs (macrophages, B cells, DCs)
Specialize in presenting antigen from extracellular spaces that have been engulfed by
APCs
Ass. with T helper cell
Question:
Mice VERSUS humans:
Answer:
H-2 complex VERSUS HLA complex
Question:
RR =
Answer:
,(frequency of allele+/allele- in diseased population) /
(frequency of allele+/allele- in general population)
Question:
RR = 1 means:
Answer:
No effect
Question:
MHC class I -
Is present on:
Answer:
All nucleated cells except for RBCs
Question:
MHC class I -
Has how many chains?
Answer:
2 chains
Alpha + beta 2 microglobulin (alpha, alpha, & beta)
Question:
MHC class I -
Info about the chains:
Answer:
Alpha chain coded on chromosome 6
Beta chain coded on chromosome 15
Beta 2 microglobulin acts as stabilizer
Alpha & alpha form cleft region that binds 8-10 AA long peptide fragment from an
antigen
Beta sheet forms the floor of the cleft
2 alpha helices form the walls
Question:
, MHC class I -
Alpha vs. beta chain encoding:
Answer:
Only alpha chain encoded in the MHC, beta joins separately
Question:
MHC class I -
Presents peptide to:
Answer:
CD8+ T cells (T cytotoxic)
Question:
MHC class I -
Responsible for:
Answer:
Graft rejection & clearance of ENDOGENOUS antigens (tumour, pathogen infected cells,
virus infected cells)
Question:
MHC class I -
What helps to anchor the peptide in the groove?
Answer:
Some AAs
Other AAs interact with TCR
Question:
MHC class II -
Is present on:
Answer:
APCs (B cells, macrophages, DCs)
Question:
MHC class II -
Responsible for:
