MICR 3230 (Immunology) Final | UPDATED Questions with 100% Verified Answers

MICR 3230 (Immunology) Final | UPDATED Questions with 100%
Verified Answers

Question:
4 principles of immunology

Answer:
Recognition, response, regulate, recall


Question:
Host strategies to deal with pathogen threat

Answer:
Avoidance (physical/chemical barriers)
Resistance (sensor/effector mechanism)
Tolerance (inflammation)


Question:
Physical barriers

Answer:
Epithelium, movement of air, movement of particles


Question:
Chemical barriers in skin

Answer:
Lamellar bodies, fatty acids, antimicrobial peptides (B-defensins, cathelicidin)


Question:
Chemical barriers in gut

Answer:
pH, mucus, antimicrobial peptides (a-defensins, RegIII, cathelicidin), pepsin


Question:
Chemical barriers in lung

Answer:

,Pulmonary surfactant, antimicrobial peptides (a-defensins, cathelicidin), mucus


Question:
Chemical barriers of eyes/nose/oral cavity

Answer:
Lysozyme (tears), antimicrobial peptides (B-defensins, histatin)


Question:
Mucus function

Answer:
Chemical barrier in gut and lungs.
Contains high concentrations of antimicrobial peptides.


Question:
Lysozyme function

Answer:
Digests peptidoglycan (G-pos more susceptible)


Question:
Antimicrobial peptides function

Answer:
Amphipathic, integrates into lipid bilayer to form pores


Question:
Myeloid lineage cells

Answer:
Granulocytes (neutrophils, eosinophils, basophils, mast cells)
Myeloid APCs (dendritic cells, macrophages, monocytes)
Erythroid cells (RBCs)


Question:
Lymphoid lineage cells

Answer:

,T cells
B cells
NK cells
ILCs


Question:
Leukocyte

Answer:
White blood cells, includes myeloid and lymphoid immune cells


Question:
Lymphocyte

Answer:
Lymphoid cells of adaptive immunity (T cells, B cells)


Question:
Innate lymphocytes

Answer:
Innate cells of lymphoid lineage (NK cells, ILCs)


Question:
Neutrophil function

Answer:
Circulate and recruited by macrophage cytokines, second on-site to infection.
Phagocytosis and bactericidal mechanisms (granule release)


Question:
Leukocyte that makes up >50% of circulating leukocytes

Answer:
Neutrophil


Question:
Eosinophil function

Answer:

, Combat parasitic infection


Question:
Basophil function

Answer:
Combat parasitic infection, allergic response


Question:
Mast cell location and function

Answer:
Tissue resident
Allergic response


Question:
APC function

Answer:
Process antigens, express MHC/HLA to present antigens to T cells


Question:
Monocyte function

Answer:
Circulate, evolve into macrophages after diapedesis


Question:
Macrophage location and functions

Answer:
Tissue residence
Phagocytosis, bactericidal mechanisms
Cytokine production
Antigen presentation


Question:
Tissue resident immune cells