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APEA Pre-Predictor Exam | Practice Questions, Verified Answers & Detailed Rationales 2026–2027

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Comprehensive APEA Pre-Predictor exam review for Nurse Practitioner students preparing for the 2026–2027 testing cycle. Covers advanced health assessment, pathophysiology, pharmacology, diagnosis and treatment, clinical decision-making, health promotion, disease prevention, and patient management across common NP practice areas. Includes practice questions, verified answers, and rationales to strengthen clinical reasoning and support APEA Pre-Predictor and nurse practitioner certification preparation.

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APEA Pre-Predictor Exam – Practice Questions &
Verified Answers with Rationales |
Comprehensive Nurse Practitioner Exam Review |
2026–2027

,What is the biggest side effect of colchicine? diarrhea




What is the biggest side effect of colchicine? diarrhea




How would you describe the appearance of molluscum papules that are umbilicated and contain a caseous plug
contagiosum?



How would you describe the appearance of molluscum papules that are umbilicated and contain a caseous plug
contagiosum?



How do we treat a broken clavicle in an infant? no treatment; it should heal on it's own




How do we treat a broken clavicle in an infant? no treatment; it should heal on it's own




At what week of pregnancy is the uterus palpable just week 12
above the pubic symphysis?



At what week of pregnancy is the uterus palpable just week 12
above the pubic symphysis?



At what week of pregnancy is the fundus palpable halfway week 16
between the pubic symphysis and umbilicus?



At what week of pregnancy is the fundus palpable halfway week 16
between the pubic symphysis and umbilicus?



At what week of pregnancy is the fundus of the uterus at week 20
the umbilicus?



At what week of pregnancy is the fundus of the uterus at week 20
the umbilicus?



At what week of pregnancy is the fundus of the uterus week 28
halfway between the xiphoid process and umbilicus?



At what week of pregnancy is the fundus of the uterus week 28
halfway between the xiphoid process and umbilicus?



At what week of pregnancy is the fundus just below the week 34
xiphoid process?

,At what week of pregnancy is the fundus just below the week 34
xiphoid process?



Increased sweat production is a sign of what endocrine hyperthyroidism
disorder?



Increased sweat production is a sign of what endocrine hyperthyroidism
disorder?



What is Paget's disease? there is localized increased bone turnover and blood flow resulting in the
breakdown of bone and replacing it with weakened and highly vascular bone putting
the indiv at increased risk of fractures


What is Paget's disease? there is localized increased bone turnover and blood flow resulting in the
breakdown of bone and replacing it with weakened and highly vascular bone putting
the indiv at increased risk of fractures


How do we treat Paget's diseease? bisphosphonates




How do we treat Paget's diseease? bisphosphonates




How should pregnant women wear their seatbelt? with the shoulder strap like a normal person and then the groin strap below the belly
and across the hips



How should pregnant women wear their seatbelt? with the shoulder strap like a normal person and then the groin strap below the belly
and across the hips



What is another name for fifth disease? parvovirus aka slapped cheek disease aka erythema infectiosum




What is another name for fifth disease? parvovirus aka slapped cheek disease aka erythema infectiosum




Which type of prevention are vaccinations? primary




Which type of prevention are vaccinations? primary




When should patients begin antiretroviral therapy for HIV as soon as it is detected, even if in the acute phase
infection?



When should patients begin antiretroviral therapy for HIV as soon as it is detected, even if in the acute phase
infection?

, What are the first generation antihistamines? diphenhydramine (benadryl) and chlorpeniramine (actifed)




What are the first generation antihistamines? diphenhydramine (benadryl) and chlorpeniramine (actifed)




What are s/s of the secondary stage of syphilis? rash on hands and feet, lymphadenopathy, fever




What are s/s of the secondary stage of syphilis? rash on hands and feet, lymphadenopathy, fever




What is the recommended treatment for chronic bacterial a fluoroquinolone (cipro or levo) + bactrim
prostatitis?



What is the recommended treatment for chronic bacterial a fluoroquinolone (cipro or levo) + bactrim
prostatitis?



What is the recommended treatment for acute prostatitis? cipro (if not STI related) or ceftriaxone




What is the recommended treatment for acute prostatitis? cipro (if not STI related) or ceftriaxone




What are s/s of an intraductal breast papilloma? clear to bloody unilateral nipple discharge (bilateral is usually benign), and also a
wart like lump palpated in the nipple area



What are s/s of an intraductal breast papilloma? clear to bloody unilateral nipple discharge (bilateral is usually benign), and also a
wart like lump palpated in the nipple area



If a patient has GABHS but has an allergy to penicillins, first generation cephalosporins, unless the allergy is severe, then you would
what is the second line option? consider macrolides like a -mycin



If a patient has GABHS but has an allergy to penicillins, first generation cephalosporins, unless the allergy is severe, then you would
what is the second line option? consider macrolides like a -mycin



PDE5 inhibitors (sildenafil, tadalafil) are contraindicated in in those who are on any type of nitrate or triptan because it could result in
which patient populations? hypotension



PDE5 inhibitors (sildenafil, tadalafil) are contraindicated in in those who are on any type of nitrate or triptan because it could result in
which patient populations? hypotension



What class of drug is sildenafil (viagra)? a PDE5 inhibitor which can cause hypotension so you should do a full cardiac
assessment before starting a patient on this and maybe do an EKG

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