2026 UTA CP2 NURS 5338 FINAL EXAM – 150
PRACTICE QUESTIONS & ANSWERS
COMPLETE STUDY GUIDE | UNIVERSITY OF
TEXAS AT ARLINGTON | LATEST 2025/2026 |
100% VERIFIED
Core Domains
• Pharmacokinetics and Pharmacodynamics
• Cardiovascular Pharmacology and Therapeutics
• Endocrine and Metabolic Disorders
• Respiratory Conditions and Management
• Infectious Diseases and Antimicrobial Therapy
• Behavioral Health and Smoking Cessation
• Urgent and Emergency Care Across the Lifespan
• Clinical Decision-Making and Patient Education
Introduction
The UTA CP2 NURS 5338 Final Exam is a comprehensive assessment for
Family Nurse Practitioner students at the University of Texas at Arlington.
This exam evaluates advanced clinical knowledge and decision-making across
the lifespan, including pharmacologic management, differential diagnosis, and
evidence-based practice. Multiple-choice and scenario-based questions test the
ability to select appropriate treatments, monitor for adverse effects, and
provide patient-centered education. Emphasis is placed on clinical reasoning,
prioritization, and application of national guidelines to ensure safe and
effective advanced practice nursing care.
,SECTION ONE: QUESTIONS 1–150
Question 1
A patient is prescribed a weak acid with a pKa of 4.5. In which body
compartment will this drug primarily be absorbed?
A. Stomach (pH 1.5-2.0)
B. Small intestine (pH 6.0-7.5)
C. Blood (pH 7.35-7.45)
D. Urine (pH 5.0-8.0)
Correct answer: A. Stomach (pH 1.5-2.0)
RATIONALE: Weak acids are non-ionized (lipid-soluble) and well
absorbed in acidic environments. Using the Henderson-Hasselbalch
equation, when pH < pKa, the acidic drug is predominantly non-ionized
(HA), favoring absorption. Stomach pH (1.5-2.0) is below the pKa of 4.5, so
the drug will be mostly non-ionized and well absorbed. Weak bases are better
absorbed in the intestine .
Question 2
A patient is taking two drugs that are highly protein-bound (98% each).
Which pharmacokinetic phenomenon is most likely to occur?
A. Decreased drug half-life
B. Drug displacement and increased free drug concentration
,C. Increased renal excretion
D. Decreased volume of distribution
Correct answer: B. Drug displacement and increased free drug
concentration
RATIONALE: When two highly protein-bound drugs are co-administered,
they compete for binding sites on plasma proteins. Displacement of one drug
by the other leads to an increase in the free (unbound) concentration of the
displaced drug, which can enhance its pharmacological effect and potentially
cause toxicity .
Question 3
A drug that is a strong CYP3A4 inducer would be expected to:
A. Increase the levels of other drugs metabolized by CYP3A4
B. Decrease the levels of other drugs metabolized by CYP3A4
C. Have no effect on drug metabolism
D. Increase its own metabolism only
Correct answer: B. Decrease the levels of other drugs metabolized by
CYP3A4
RATIONALE: CYP3A4 inducers (e.g., rifampin, carbamazepine,
phenytoin) increase the expression and activity of the CYP3A4 enzyme,
leading to enhanced metabolism and decreased plasma levels of other drugs
that are substrates for this enzyme. This can result in reduced therapeutic
efficacy of the affected drugs .
Question 4
Which of the following is NOT FDA-approved for smoking cessation?
, A. Varenicline
B. Bupropion
C. Nortriptyline
D. Nicotine lozenge
Correct answer: C. Nortriptyline
RATIONALE: Nortriptyline is a tricyclic antidepressant that is used off-
label for smoking cessation. Varenicline, bupropion, and nicotine
replacement therapies (including lozenges) are FDA-approved for this
indication .
Question 5
A patient states, "I will quit smoking next month." According to the
Transtheoretical Model of Change, which stage is this patient in?
A. Precontemplation
B. Contemplation
C. Preparation
D. Maintenance
Correct answer: C. Preparation
RATIONALE: The preparation stage is characterized by the intention to
take action within the next 30 days, often accompanied by some small
behavioral changes. Planning to quit within 30 days indicates the preparation
stage .
Question 6
What is the primary goal of motivational interviewing?
A. Confront the patient about their unhealthy behaviors
B. Educate the patient on the risks of their behaviors
PRACTICE QUESTIONS & ANSWERS
COMPLETE STUDY GUIDE | UNIVERSITY OF
TEXAS AT ARLINGTON | LATEST 2025/2026 |
100% VERIFIED
Core Domains
• Pharmacokinetics and Pharmacodynamics
• Cardiovascular Pharmacology and Therapeutics
• Endocrine and Metabolic Disorders
• Respiratory Conditions and Management
• Infectious Diseases and Antimicrobial Therapy
• Behavioral Health and Smoking Cessation
• Urgent and Emergency Care Across the Lifespan
• Clinical Decision-Making and Patient Education
Introduction
The UTA CP2 NURS 5338 Final Exam is a comprehensive assessment for
Family Nurse Practitioner students at the University of Texas at Arlington.
This exam evaluates advanced clinical knowledge and decision-making across
the lifespan, including pharmacologic management, differential diagnosis, and
evidence-based practice. Multiple-choice and scenario-based questions test the
ability to select appropriate treatments, monitor for adverse effects, and
provide patient-centered education. Emphasis is placed on clinical reasoning,
prioritization, and application of national guidelines to ensure safe and
effective advanced practice nursing care.
,SECTION ONE: QUESTIONS 1–150
Question 1
A patient is prescribed a weak acid with a pKa of 4.5. In which body
compartment will this drug primarily be absorbed?
A. Stomach (pH 1.5-2.0)
B. Small intestine (pH 6.0-7.5)
C. Blood (pH 7.35-7.45)
D. Urine (pH 5.0-8.0)
Correct answer: A. Stomach (pH 1.5-2.0)
RATIONALE: Weak acids are non-ionized (lipid-soluble) and well
absorbed in acidic environments. Using the Henderson-Hasselbalch
equation, when pH < pKa, the acidic drug is predominantly non-ionized
(HA), favoring absorption. Stomach pH (1.5-2.0) is below the pKa of 4.5, so
the drug will be mostly non-ionized and well absorbed. Weak bases are better
absorbed in the intestine .
Question 2
A patient is taking two drugs that are highly protein-bound (98% each).
Which pharmacokinetic phenomenon is most likely to occur?
A. Decreased drug half-life
B. Drug displacement and increased free drug concentration
,C. Increased renal excretion
D. Decreased volume of distribution
Correct answer: B. Drug displacement and increased free drug
concentration
RATIONALE: When two highly protein-bound drugs are co-administered,
they compete for binding sites on plasma proteins. Displacement of one drug
by the other leads to an increase in the free (unbound) concentration of the
displaced drug, which can enhance its pharmacological effect and potentially
cause toxicity .
Question 3
A drug that is a strong CYP3A4 inducer would be expected to:
A. Increase the levels of other drugs metabolized by CYP3A4
B. Decrease the levels of other drugs metabolized by CYP3A4
C. Have no effect on drug metabolism
D. Increase its own metabolism only
Correct answer: B. Decrease the levels of other drugs metabolized by
CYP3A4
RATIONALE: CYP3A4 inducers (e.g., rifampin, carbamazepine,
phenytoin) increase the expression and activity of the CYP3A4 enzyme,
leading to enhanced metabolism and decreased plasma levels of other drugs
that are substrates for this enzyme. This can result in reduced therapeutic
efficacy of the affected drugs .
Question 4
Which of the following is NOT FDA-approved for smoking cessation?
, A. Varenicline
B. Bupropion
C. Nortriptyline
D. Nicotine lozenge
Correct answer: C. Nortriptyline
RATIONALE: Nortriptyline is a tricyclic antidepressant that is used off-
label for smoking cessation. Varenicline, bupropion, and nicotine
replacement therapies (including lozenges) are FDA-approved for this
indication .
Question 5
A patient states, "I will quit smoking next month." According to the
Transtheoretical Model of Change, which stage is this patient in?
A. Precontemplation
B. Contemplation
C. Preparation
D. Maintenance
Correct answer: C. Preparation
RATIONALE: The preparation stage is characterized by the intention to
take action within the next 30 days, often accompanied by some small
behavioral changes. Planning to quit within 30 days indicates the preparation
stage .
Question 6
What is the primary goal of motivational interviewing?
A. Confront the patient about their unhealthy behaviors
B. Educate the patient on the risks of their behaviors
