CSPT Practice Exam 2025 with correct
answers and rationale updated 2026
Domain 1: Medications and Components (17%)
1. Which of the following is classified as a high-alert medication due to its narrow therapeutic
index?
A. Amoxicillin
B. Heparin
C. Acetaminophen
D. Ondansetron
Answer: B
Rationale: Heparin is classified as a high-alert medication because errors in dosing or concentration
can cause serious bleeding or thrombotic events. High-alert medications require special safeguards
including independent double-checks and clear labeling -12.
2. A pharmacy technician is preparing a chemotherapy agent. Which organization maintains the
list of hazardous drugs used in healthcare?
A. FDA
B. DEA
C. NIOSH
D. OSHA
Answer: C
Rationale: NIOSH (National Institute for Occupational Safety and Health) maintains the list of
antineoplastic and other hazardous drugs used in healthcare settings -9.
3. What is the generic name for the medication Taxotere?
A. Paclitaxel
B. Docetaxel
C. Cisplatin
D. Doxorubicin
Answer: B
Rationale: Docetaxel is the generic name for Taxotere. It is an antineoplastic agent requiring special
handling per USP <800> -9.
4. Which medication would an obstetrician use to induce labor in a patient?
A. Oxytocin
B. Methylergonovine
C. Terbutaline
D. Magnesium sulfate
Answer: A
Rationale: Oxytocin is used to induce labor by stimulating uterine contractions -9.
,5. Which of the following medications is classified as an alkylating agent?
A. Methotrexate
B. Cisplatin
C. Fluorouracil
D. Vincristine
Answer: B
Rationale: Cisplatin is an alkylating agent used in chemotherapy. Alkylating agents work by cross-
linking DNA strands to prevent cell division -9.
6. A patient has been diagnosed with dysrhythmia. Which medication would a provider administer
intravenously to treat this condition?
A. Amiodarone
B. Lisinopril
C. Metformin
D. Atorvastatin
Answer: A
Rationale: Amiodarone is an antiarrhythmic agent administered intravenously to treat
dysrhythmias -9.
7. Which substance should be used when decontaminating cartoned supplies?
A. Sterile water
B. Spray disinfectant
C. Alcohol wipes
D. Hydrogen peroxide
Answer: B
Rationale: Spray disinfectant should be used to decontaminate cartoned supplies before they enter
the sterile compounding area. Cartons should be wiped down or sprayed to remove surface
contaminants -9.
8. What is the in-use time for a single-dose container in an ISO 5 environment?
A. 1 hour
B. 4 hours
C. 6 hours
D. 24 hours
Answer: C
Rationale: A single-dose container should be used within 6 hours of opening in an ISO 5 environment
unless otherwise specified by the manufacturer -5-9.
9. A patient has been diagnosed with rheumatoid arthritis. Which of the following would be an
appropriate medication to treat the patient?
A. Methotrexate injection
B. Insulin glargine
C. Levothyroxine
D. Warfarin
, Answer: A
Rationale: Methotrexate is used to treat rheumatoid arthritis. It is classified as a hazardous drug
requiring special handling during compounding -5.
10. A physician has prescribed Lovenox for a patient. Which generic medication should the
pharmacy technician select from the shelf?
A. Enoxaparin sodium injection
B. Heparin sodium injection
C. Warfarin sodium
D. Apixaban
Answer: A
Rationale: Enoxaparin sodium injection is the generic name for Lovenox, a low molecular weight
heparin used for anticoagulation -9.
11. Which of the following is considered a small-volume parenteral?
A. 50 mL
B. 250 mL
C. 500 mL
D. 1000 mL
Answer: A
Rationale: A small-volume parenteral contains 100 mL or less. Large-volume parenterals typically
exceed 100 mL -9.
12. Which medication would be used as an antidote for heparin overdose?
A. Vitamin K
B. Protamine sulfate
C. Naloxone
D. Flumazenil
Answer: B
Rationale: Protamine sulfate is the antidote for heparin overdose. It neutralizes heparin's
anticoagulant effects -9.
13. A pharmacy technician is referring to an SDS. What type of information would they find?
A. Safety data information about hazardous substances
B. Patient medication history
C. Insurance billing codes
D. Drug interaction alerts
Answer: A
Rationale: Safety Data Sheets (SDS) provide information about hazardous substances including
handling, storage, and emergency procedures -9.
14. What is the generic name for the chemotherapy agent Taxotere?
A. Docetaxel
B. Paclitaxel
answers and rationale updated 2026
Domain 1: Medications and Components (17%)
1. Which of the following is classified as a high-alert medication due to its narrow therapeutic
index?
A. Amoxicillin
B. Heparin
C. Acetaminophen
D. Ondansetron
Answer: B
Rationale: Heparin is classified as a high-alert medication because errors in dosing or concentration
can cause serious bleeding or thrombotic events. High-alert medications require special safeguards
including independent double-checks and clear labeling -12.
2. A pharmacy technician is preparing a chemotherapy agent. Which organization maintains the
list of hazardous drugs used in healthcare?
A. FDA
B. DEA
C. NIOSH
D. OSHA
Answer: C
Rationale: NIOSH (National Institute for Occupational Safety and Health) maintains the list of
antineoplastic and other hazardous drugs used in healthcare settings -9.
3. What is the generic name for the medication Taxotere?
A. Paclitaxel
B. Docetaxel
C. Cisplatin
D. Doxorubicin
Answer: B
Rationale: Docetaxel is the generic name for Taxotere. It is an antineoplastic agent requiring special
handling per USP <800> -9.
4. Which medication would an obstetrician use to induce labor in a patient?
A. Oxytocin
B. Methylergonovine
C. Terbutaline
D. Magnesium sulfate
Answer: A
Rationale: Oxytocin is used to induce labor by stimulating uterine contractions -9.
,5. Which of the following medications is classified as an alkylating agent?
A. Methotrexate
B. Cisplatin
C. Fluorouracil
D. Vincristine
Answer: B
Rationale: Cisplatin is an alkylating agent used in chemotherapy. Alkylating agents work by cross-
linking DNA strands to prevent cell division -9.
6. A patient has been diagnosed with dysrhythmia. Which medication would a provider administer
intravenously to treat this condition?
A. Amiodarone
B. Lisinopril
C. Metformin
D. Atorvastatin
Answer: A
Rationale: Amiodarone is an antiarrhythmic agent administered intravenously to treat
dysrhythmias -9.
7. Which substance should be used when decontaminating cartoned supplies?
A. Sterile water
B. Spray disinfectant
C. Alcohol wipes
D. Hydrogen peroxide
Answer: B
Rationale: Spray disinfectant should be used to decontaminate cartoned supplies before they enter
the sterile compounding area. Cartons should be wiped down or sprayed to remove surface
contaminants -9.
8. What is the in-use time for a single-dose container in an ISO 5 environment?
A. 1 hour
B. 4 hours
C. 6 hours
D. 24 hours
Answer: C
Rationale: A single-dose container should be used within 6 hours of opening in an ISO 5 environment
unless otherwise specified by the manufacturer -5-9.
9. A patient has been diagnosed with rheumatoid arthritis. Which of the following would be an
appropriate medication to treat the patient?
A. Methotrexate injection
B. Insulin glargine
C. Levothyroxine
D. Warfarin
, Answer: A
Rationale: Methotrexate is used to treat rheumatoid arthritis. It is classified as a hazardous drug
requiring special handling during compounding -5.
10. A physician has prescribed Lovenox for a patient. Which generic medication should the
pharmacy technician select from the shelf?
A. Enoxaparin sodium injection
B. Heparin sodium injection
C. Warfarin sodium
D. Apixaban
Answer: A
Rationale: Enoxaparin sodium injection is the generic name for Lovenox, a low molecular weight
heparin used for anticoagulation -9.
11. Which of the following is considered a small-volume parenteral?
A. 50 mL
B. 250 mL
C. 500 mL
D. 1000 mL
Answer: A
Rationale: A small-volume parenteral contains 100 mL or less. Large-volume parenterals typically
exceed 100 mL -9.
12. Which medication would be used as an antidote for heparin overdose?
A. Vitamin K
B. Protamine sulfate
C. Naloxone
D. Flumazenil
Answer: B
Rationale: Protamine sulfate is the antidote for heparin overdose. It neutralizes heparin's
anticoagulant effects -9.
13. A pharmacy technician is referring to an SDS. What type of information would they find?
A. Safety data information about hazardous substances
B. Patient medication history
C. Insurance billing codes
D. Drug interaction alerts
Answer: A
Rationale: Safety Data Sheets (SDS) provide information about hazardous substances including
handling, storage, and emergency procedures -9.
14. What is the generic name for the chemotherapy agent Taxotere?
A. Docetaxel
B. Paclitaxel
