CHT EXAM PREP ACTUAL TEST QUESTIONS
AND CORRECT ANSWERS COMPLETE REVIEW
◉ The immunoglobulin that binds the most complement is
a. IgA
b. IgD
c. IgM
d. IgG2
e. IgE.
Answer: c. IgM
◉ The immunoglobulin responsible for activating mast cells in an
allergic response is
a. IgA
b. IgD
c. IgM
d. IgG
e. IgE.
Answer: e. IgE
,◉ The molecular interaction between an antibody and its
corresponding antigen is mediated by all except which of the
following?
a. Hydrogen bonds
b. Hydrophobic interactions
c. Covalent bonds
d. Electrostatic interactions
e. Van der Waals interactions..
Answer: c. Covalent bonds
◉ The phenomenon of 'affinity maturation,' in which later
antibodies bind to antigen with a higher affinity than the ones made
weeks earlier, is due to
a. Allelic exclusion
b. VDJ recombination
c. Isotype switching
d. Junctional flexibility
e. Somatic hypermutation.
Answer: e. Somatic hypermutation
,◉ Positive and negative selection of T cells occurs...
a. Before TCR gene rearrangement
b. After TCR gene rearrangement
c. After T cells have left the thymus
d. In the bone marrow
e. In the spleen.
Answer: b. After TCR gene rearrangement
◉ Antibodies in the serum of a transplant recipient that react with
HLA class I (HLA-A,B,C) antigens on the donor are particular
dangerous in that they can induce...
a. Hyperacute rejection
b. Acute rejection
c. Chronic rejection
d. Type III hypersensitivity reactions
e. Type I anaphylactic reactions.
Answer: a. Hyperacute rejection
◉ Which of the following immunosuppressive drugs could be
classified as an antiproliferative (anti-metabolite)?
, a. Cyclosporine
b. FK506
c. Rapamycin
d. Azathioprine
e. Prednisolone (steroids).
Answer: d. Azathioprine
◉ Recipients of organ transplants are generally required to take
immunosuppressive drugs for ...
a. 6 months
b. 2-5 years
c. 10-15 years
d. Until there is no evidence of rejection
e. For the remainder of their lives.
Answer: e. For the remainder of their lives
◉ If HLA-A, HLA-B and HLA-DR alleles are compared between a
parent and a child, how many would you typically expect to be
matched?
AND CORRECT ANSWERS COMPLETE REVIEW
◉ The immunoglobulin that binds the most complement is
a. IgA
b. IgD
c. IgM
d. IgG2
e. IgE.
Answer: c. IgM
◉ The immunoglobulin responsible for activating mast cells in an
allergic response is
a. IgA
b. IgD
c. IgM
d. IgG
e. IgE.
Answer: e. IgE
,◉ The molecular interaction between an antibody and its
corresponding antigen is mediated by all except which of the
following?
a. Hydrogen bonds
b. Hydrophobic interactions
c. Covalent bonds
d. Electrostatic interactions
e. Van der Waals interactions..
Answer: c. Covalent bonds
◉ The phenomenon of 'affinity maturation,' in which later
antibodies bind to antigen with a higher affinity than the ones made
weeks earlier, is due to
a. Allelic exclusion
b. VDJ recombination
c. Isotype switching
d. Junctional flexibility
e. Somatic hypermutation.
Answer: e. Somatic hypermutation
,◉ Positive and negative selection of T cells occurs...
a. Before TCR gene rearrangement
b. After TCR gene rearrangement
c. After T cells have left the thymus
d. In the bone marrow
e. In the spleen.
Answer: b. After TCR gene rearrangement
◉ Antibodies in the serum of a transplant recipient that react with
HLA class I (HLA-A,B,C) antigens on the donor are particular
dangerous in that they can induce...
a. Hyperacute rejection
b. Acute rejection
c. Chronic rejection
d. Type III hypersensitivity reactions
e. Type I anaphylactic reactions.
Answer: a. Hyperacute rejection
◉ Which of the following immunosuppressive drugs could be
classified as an antiproliferative (anti-metabolite)?
, a. Cyclosporine
b. FK506
c. Rapamycin
d. Azathioprine
e. Prednisolone (steroids).
Answer: d. Azathioprine
◉ Recipients of organ transplants are generally required to take
immunosuppressive drugs for ...
a. 6 months
b. 2-5 years
c. 10-15 years
d. Until there is no evidence of rejection
e. For the remainder of their lives.
Answer: e. For the remainder of their lives
◉ If HLA-A, HLA-B and HLA-DR alleles are compared between a
parent and a child, how many would you typically expect to be
matched?
