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ATI Pharmacology Proctored Exam | Practice Questions & Verified Answers | Pharmacology CMS 2026/2027

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Prepare for the ATI Pharmacology Proctored Exam with focused practice questions and detailed rationales covering essential nursing pharmacology concepts. Topics include medication classifications, pharmacokinetics and pharmacodynamics, therapeutic effects, adverse reactions, contraindications, drug interactions, safe medication administration, client assessment and education, dosage considerations, and medications affecting major body systems including cardiovascular, respiratory, neurologic, endocrine, gastrointestinal, hematologic, reproductive, immune, and infectious conditions. This resource is designed to reinforce pharmacology knowledge, strengthen clinical reasoning, and support preparation for ATI Pharmacology Content Mastery Series assessments.

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ATI Pharmacology Proctor Exam
A nurse is assessing a client who is receiving intravenous b. Distended neck veins
therapy. The nurse should identify which of the following
findings as a manifestation of fluid volume excess?
a. Decreased bowel sounds
b. Distended neck veins
c. Bilateral muscle weakness
d. Thread pulse


A nurse is caring for a client who has hyponatremia and is b. Improved cognition
receiving an infusion of a prescribed hypertonic solution.
Which of the following findings should indicate to the nurse
that the treatment is effective?
a. Absent Chvostek's sign
b. Improved cognition
c. Decreased vomiting
d. Cardiac arrhythmias absent


A nurse is teaching a client who has a new prescription for d. "Remove the patch prior to going to bed."
a nitroglycerin transdermal patch. Which of the following
instructions should the nurse include?
a. "Discontinue the patch if you experience a headache."
b. "Apply a new patch if you have chest pain."
c. "Cover the patch with dry gauze when taking a shower."
d. "Remove the patch prior to going to bed."


A nurse is reviewing he laboratory results of a client who d. Potassium 5.2 mEq/L - Hyperkalemia (serum potassium level greater than 5.0
has a prescription for sodium polystyrene sulfonate mEq/L) increases the client risk for fatal cardiac dysrhythmias. Kayexalate is used
(Kayexalate) every 6 hr. which of the following should the to decrease the serum potassium level so the PN should monitor the client's serum
nurse report to the provider? potassium level
a. Creatinine 0.72 mg/dL
b. Sodium 138 mEq/L
c. Magnesium 2 mEq/L
d. Potassium 5.2 mEq/L


A nurse is caring for a client who has tuberculosis and is a. The client has a negative sputum culture
taking isoniazid and rifampin. Which of the following
outcomes indicates that the client is adhering to the
medication regimen?
a. The client has a negative sputum culture
b. The client tests negative for HIV
c. The client has a positive purified protein derivative test
d. The client's liver function test results are within the
expected reference range


A client is caring for a client who develops an anaphylactic d. Administer epinephrine IM
reaction to IV administration. After assessing the client's
respiratory status and stopping the medication infusion.
Which of the following actions should the nurse take next?
a. Replace the infusion with 0.9% sodium chloride
b. Give diphenhydramine IM
c. Elevate the client's legs and feet
d. Administer epinephrine IM


A nurse is caring for a client who is taking sertraline and a. St. John's Wort
reports a desire to begin taking supplements. Which of the
following supplements should the nurse advise the client to
avoid?
a. St. John's Wort
b. Ginger root
c. Black cohosh
d. Coenzyme Q10


A nurse is caring for a client who has heart failure and a d. Hypotension
new prescription for lisinopril. For which of the following
adverse effects should the nurse monitor when
administering lisinopril?
a. Bradycardia
b. Hypokalemia
c. Tinnitus
d. Hypotension

, ATI Pharmacology Proctor Exam
A nurse is assessing a client who is receiving heparin IV d. Increased blood pressure
continuous IV. The client has an PPT of 90 seconds. They
should monitor the client for which of the following changes
in their vital signs?
a. Decreased temperature
b. Increased pulse rate
c. Decreased respiratory rate
d. Increased blood pressure


A nurse is preparing to administer medication to a client b. The nurse who identifies the error
and discovers a medication error. The nurse should
recognize that which of the following staff members is
responsible for completing an incident report?
a. The quality improvement committee
b. The nurse who identifies the error
c. The nurse who caused the error
d. The charge nurse


A nurse is planning care for a client who is receiving a. Pruritus - Sign of allergic reaction to morphine
morphine via continuous epidural infusion. The nurse
should monitor the client for which of the following?
a. Pruritus
b. Cough
c. Tachypnea
d. Gastric bleeding


A nurse is preparing to administer digoxin orally to a client. a. Obtain the client's apical heart rate
Identify the sequence of steps the nurse should take. b. Remove the medication from the dispensing system
(Move the steps into the box on the right placing them in c. Open the medication package
the order of performance. Use all the steps.) d. Compare the client's wristband to the medication administration record
e. Document administration of the medication


A nurse is reviewing the medical record of an adult client a. Alcohol use disorder
who has a fever and a prescription for acetaminophen.
Which of the following findings should the nurse identify as b. Chronic kidney disease
a contraindication for receiving this medication?
a. Alcohol use disorder
b. Chronic kidney disease
c. Hepatitis B vaccine within the last week
d. Diabetes mellitus


A home health nurse is visiting a client who has heart c. Determine medication adherence by the client
failure and a prescription for furosemide. The nurse
identifies that the client has gained 2.5 kg (5 lb.) since the
last visit 2 days ago. Which of the following actions should
the nurse take first?
a. Encourage the client to dangle the legs while sitting in a
chair
b. Teach the client about foods low in sodium
c. Determine medication adherence by the client
d. Notify the provider of the client's weight gain


A nurse is preparing to administer the initial dose of a. Urticaria
penicillin G IM to a client. The nurse should monitor for
which of the following as an indication of an allergic
reaction following the injection?
a. Urticaria
b. Bradycardia
c. Pallor
d. Dyspepsia

, ATI Pharmacology Proctor Exam
A nurse is teaching a client who has angina a new c. "Keep the tablets at room temperature in their original glass bottle."
prescription for sublingual nitroglycerin tablets. Which of
the following instructions should the nurse include in the
teaching?
a. "Discard any tablets you do not use every 6 months."
b. "Take one tablet each morning 30 minutes prior to
eating."
c. "Keep the tablets at room temperature in their original
glass bottle."
d. "Place the tablet between your cheek and gum to
dissolve."


A nurse is providing teaching to a client who has a new a. "I can take my medication in the morning with my coffee."
prescription for theophylline a sustained-released capsule.
Which of the following statements by the client indicates an
understanding of the teaching?
a. "I can take my medication in the morning with my
coffee."
b. "I may sprinkle the medication in applesauce."
c. "I should limit my fluid intake while on this medication."
d. "I will need to have blood levels drawn."


A nurse is mixing regular insulin and NPH insulin in the c. Inject air into the NPH vial
same syringe prior to administering it to client who has
diabetes mellitus following actions should the nurse take
first?
a. Withdraw the regular insulin from the viral
b. Withdraw the NPH insulin form the vial
c. Inject air into the NPH vial
d. Inject air into the regular insulin vial


A nurse is preparing to administer subcutaneous heparin d. Insert the needle at least 5 cm (2 in) from the umbilicus
to a client. Which of the following should the nurse take?
a. Massage the site after administering the medication
b. Use a 21-gauge needle for the injection
c. Aspirate before injecting the medication
d. Insert the needle at least 5 cm (2 in) from the umbilicus


A nurse is caring for a client who has a prescription for c. Laryngeal edema
amoxicillin. Which of the following findings indicates the
client is experiencing an allergic reaction? b. Cardiac dysrhythmia
a. Nausea
b. Cardiac dysrhythmia Amoxicillin side effects include: Renal impairment, hyperkalemia, dysrhythmias,
c. Laryngeal edema hypernatremia
d. Insomnia
Allergic reaction: Urticaria, rash, hypotension, dyspnea, swelling of face/lips/tongue


A nurse is teaching a newly licensed nurse about c. A client who is transferal to a step-down unit
medication reconciliation. The nurse should instruct the
newly licensed nurse to perform medication reconciliation
for which of the following?
a. A client who has a referral for social services
b. A client who is transdermal to radiology
c. A client who is transferal to a step-down unit
d. A client who has a consultation for physical therapy


A nurse is reviewing the laboratory values of a client who is d. LDL 120 mg/dL
taking atorvastatin. Which of the following laboratory
values indicates the treatment has been effective?
a. BUN 15 mg/dL
b. Blood glucose 90 mg/dL
c. Urine specific gravity 1.020
d. LDL 120 mg/dL

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