NAPLEX ID 1&2 |ACTUAL QUESTIONS AND
VERIFIED ANSWERS|BRAND NEW 2026-2027
UPDATE|GRADED A+
Question 1
Choose the correct statements concerning vancomycin
pharmacodynamics/pharmacokinetics and therapeutic drug monitoring. (Select ALL that
apply.)
A. Vancomycin exhibits time dependent killing
B. Target an AUC/MIC ratio of 400-600 is recommended for serious MRSA infections
C. Alternative agents should be considered if the vancomycin MIC is > or equal to 2 mcg/mL
D. A 1500 mg dose should be infused over 30 minutes
E. Vancomycin troughs should be drawn at steady state **generally before 4th dose**
CORRECT ANSWER
B, C, D=E
B. Target an AUC/MIC ratio of 400-600 is recommended for serious MRSA infections
C. Alternative agents should be considered if the vancomycin MIC is > or equal to 2
mcg/mL
E. Vancomycin troughs should be drawn at steady state **generally before 4th dose**
Question 2
Which of the following groups of pathogens best represents clindamycin's spectrum of
activity?
A. Atypicals and anaerobic pathogens
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@THE STUDY VAULT
,B. Multi-resistant Gram negative pathogens (Acinetobacter, Pseudomonas) and skin flora
(Streptococci, stayphlococci)
C. Enteric gram negative pathogens and anaeorbic pathogens
D. Parasitic and fungal pathogens
E. Aerobic (Streptococci, staphylococci) and anerobic gram positive pathogens
CORRECT ANSWER
E. Aerobic (Streptococci, staphylococci) and anerobic gram positive pathogens
Question 3
Which of the following statements is INCORRECT regarding daptomycin?
A. It exhibits concentration-dependent killing
B. The intravenous formulation is incompatible with D5W
C. It is associated with myopathy/muscle toxicity, thus monitor for creatinine kinase
D. It requires dose adjustments for moderate to severe renal impairment
E. Oral formulation has excellent bioavailability
CORRECT ANSWER
E. Oral formulation has excellent bioavailability
Question 4
A patient with multidrug-resistant (MDR) Pseudomonas aeruginosa isolated from the
urine culture is admitted to the hospital. The physician would like to avoid using a
medication that can worsen kidney function as the patient's SCr has increased from 0.7 to
1.4 over the past week. Which of the following drugs would you recommend?
A. Clindamycin
B. Ceftriaxone
2
@THE STUDY VAULT
, C. Ceftolozane/Tazobactam
D. Oritavancin
E. Tobramycin
CORRECT ANSWER
C. Ceftolozane/Tazobactam
- because it has activity vs. MDR gram negative bacteria including Pseudomonas and is
approved for UTIs
Question 5
Medication orders for active pulmonary tuberculosis are sent to the pharmacy for a 27-
year-old female. While processing the orders, the pharmacist receives an alert, warning of
a drug interaction between rifampin and an existing medication previously prescribed to
this patient. Which of the following medications would prompt an alert?
A. Allopurinol
B. Apixaban
C. Chlorthalidone
D. Methotrexate
E. Ramipril
CORRECT ANSWER
B. Apixaban
- substrate of CYP3A4 and Pgp
- when taken concurrently with Rifampin, apixaban serum concentrations decrease
significantly because of
--decreased absorption (More drug is eliminated via Pgp efflux)
3
@THE STUDY VAULT
VERIFIED ANSWERS|BRAND NEW 2026-2027
UPDATE|GRADED A+
Question 1
Choose the correct statements concerning vancomycin
pharmacodynamics/pharmacokinetics and therapeutic drug monitoring. (Select ALL that
apply.)
A. Vancomycin exhibits time dependent killing
B. Target an AUC/MIC ratio of 400-600 is recommended for serious MRSA infections
C. Alternative agents should be considered if the vancomycin MIC is > or equal to 2 mcg/mL
D. A 1500 mg dose should be infused over 30 minutes
E. Vancomycin troughs should be drawn at steady state **generally before 4th dose**
CORRECT ANSWER
B, C, D=E
B. Target an AUC/MIC ratio of 400-600 is recommended for serious MRSA infections
C. Alternative agents should be considered if the vancomycin MIC is > or equal to 2
mcg/mL
E. Vancomycin troughs should be drawn at steady state **generally before 4th dose**
Question 2
Which of the following groups of pathogens best represents clindamycin's spectrum of
activity?
A. Atypicals and anaerobic pathogens
1
@THE STUDY VAULT
,B. Multi-resistant Gram negative pathogens (Acinetobacter, Pseudomonas) and skin flora
(Streptococci, stayphlococci)
C. Enteric gram negative pathogens and anaeorbic pathogens
D. Parasitic and fungal pathogens
E. Aerobic (Streptococci, staphylococci) and anerobic gram positive pathogens
CORRECT ANSWER
E. Aerobic (Streptococci, staphylococci) and anerobic gram positive pathogens
Question 3
Which of the following statements is INCORRECT regarding daptomycin?
A. It exhibits concentration-dependent killing
B. The intravenous formulation is incompatible with D5W
C. It is associated with myopathy/muscle toxicity, thus monitor for creatinine kinase
D. It requires dose adjustments for moderate to severe renal impairment
E. Oral formulation has excellent bioavailability
CORRECT ANSWER
E. Oral formulation has excellent bioavailability
Question 4
A patient with multidrug-resistant (MDR) Pseudomonas aeruginosa isolated from the
urine culture is admitted to the hospital. The physician would like to avoid using a
medication that can worsen kidney function as the patient's SCr has increased from 0.7 to
1.4 over the past week. Which of the following drugs would you recommend?
A. Clindamycin
B. Ceftriaxone
2
@THE STUDY VAULT
, C. Ceftolozane/Tazobactam
D. Oritavancin
E. Tobramycin
CORRECT ANSWER
C. Ceftolozane/Tazobactam
- because it has activity vs. MDR gram negative bacteria including Pseudomonas and is
approved for UTIs
Question 5
Medication orders for active pulmonary tuberculosis are sent to the pharmacy for a 27-
year-old female. While processing the orders, the pharmacist receives an alert, warning of
a drug interaction between rifampin and an existing medication previously prescribed to
this patient. Which of the following medications would prompt an alert?
A. Allopurinol
B. Apixaban
C. Chlorthalidone
D. Methotrexate
E. Ramipril
CORRECT ANSWER
B. Apixaban
- substrate of CYP3A4 and Pgp
- when taken concurrently with Rifampin, apixaban serum concentrations decrease
significantly because of
--decreased absorption (More drug is eliminated via Pgp efflux)
3
@THE STUDY VAULT
