IMMUNOLOGY KUBY CHAPTER 5
INNATE IMMUNITY EXAM Q&A
1. A mixture of S. aureus and the enteric bacteria E. coli was placed onto the skin of the
fingertips of a volunteer. The volunteer immediately touched one of their inoculated
fingertips to nutrient agar plate #1 and then waited 30 minutes and touched a different
inoculated finger to nutrient agar plate #2. After incubating the plates overnight, what
pattern of growth would you expect to see on the plates?
A. Both E. coli and S. aureus grew on both plates.
B. Plate #1 grew both, while plate #2 grew only S. aureus.
C. Plate #1 grew both, while plate #2 grew only E. coli.
D. Plate #1 grew only S. aureus, while plate #2 grew both.
E. Plate #1 grew only E. coli, while plate #2 grew both. - ANSWER -Answer: B
Section: Anatomical Barriers to Infection
Difficulty: 3
Hint: The skin contains psoriasin, an antibacterial protein.
(the innate immune system would recognize ecoli and the finger. s aureus always there)
2. Where would you be LEAST likely to find significant levels of defensins?
A. The lung
B. The intestine
C. The liver
D. The skin
E. The bladder - ANSWER -Answer: C
Section: Anatomical Barriers to Infection
Difficulty: 2
Hint: Defensins are found in locations where pathogens first contact the host.
3. Which of the following is the CORRECT relationship? _______________ on
_____________ recognize _________________ on ____________________.
A. PRRs; macrophages; PAMPs; pathogens
B. PRRs; pathogens; PAMPs; macrophages
C. PAMPs; macrophages; PRRs; pathogens
D. PAMPs; neutrophils; PRR; pathogens
E. PRRs; macrophages; PAMPs; neutrophils - ANSWER -Answer: A
Section: Phagocytosis
Difficulty: 2
Hint: PRRs are found on antigen-presenting cells.
4. Which of the following is NOT entirely a response of the innate immune system?
, A. Phagocytosis by macrophages
B. Protection from infection by the skin
C. Low pH in the stomach
D. Antibody mediated complement activation
E. Microbial cell lysis by defensin - ANSWER -Answer: D
Section: Introduction
Difficulty: 2
Hint: What makes antibodies?
5. Which of these characteristics are adaptive?
A. Response takes several days to develop
B. Responds more quickly upon secondary exposure to pathogens
C. Pathogen receptors are extremely varied
D. Recognize broad classes of pathogens
E. A, B, and C - ANSWER -Answer: E
Section: Introduction
Difficulty: 1
Hint: Review Table 5-1.
6. Which of these characteristics are innate?
A. Found in all multicellular plants and animals
B. Receptors are encoded in the germline
C. Recognize broad classes of pathogens
D. Responds more quickly upon secondary exposure to pathogens
E. A, B, and C - ANSWER -Answer: E
Section: Introduction
Difficulty: 1
Hint: Review Table 5-1.
7. Why are many opsonins multimeric?
A. Because they are all derived from the same proto-opsonin
B. Because they bind repeating structures on pathogen surfaces
C. So that they can be regulated allosterically
D. Because they have to crosslink receptors on phagocytes in order for phagocytosis to
occur
E. Because one subunit binds pathogen and the other has enzymatic activity -
ANSWER -Answer: B
Section: Phagocytosis
Difficulty: 2
Hint: Multimeric receptors have several identical binding sites.
8. Which of the following are associated with damaged or dead cells?
INNATE IMMUNITY EXAM Q&A
1. A mixture of S. aureus and the enteric bacteria E. coli was placed onto the skin of the
fingertips of a volunteer. The volunteer immediately touched one of their inoculated
fingertips to nutrient agar plate #1 and then waited 30 minutes and touched a different
inoculated finger to nutrient agar plate #2. After incubating the plates overnight, what
pattern of growth would you expect to see on the plates?
A. Both E. coli and S. aureus grew on both plates.
B. Plate #1 grew both, while plate #2 grew only S. aureus.
C. Plate #1 grew both, while plate #2 grew only E. coli.
D. Plate #1 grew only S. aureus, while plate #2 grew both.
E. Plate #1 grew only E. coli, while plate #2 grew both. - ANSWER -Answer: B
Section: Anatomical Barriers to Infection
Difficulty: 3
Hint: The skin contains psoriasin, an antibacterial protein.
(the innate immune system would recognize ecoli and the finger. s aureus always there)
2. Where would you be LEAST likely to find significant levels of defensins?
A. The lung
B. The intestine
C. The liver
D. The skin
E. The bladder - ANSWER -Answer: C
Section: Anatomical Barriers to Infection
Difficulty: 2
Hint: Defensins are found in locations where pathogens first contact the host.
3. Which of the following is the CORRECT relationship? _______________ on
_____________ recognize _________________ on ____________________.
A. PRRs; macrophages; PAMPs; pathogens
B. PRRs; pathogens; PAMPs; macrophages
C. PAMPs; macrophages; PRRs; pathogens
D. PAMPs; neutrophils; PRR; pathogens
E. PRRs; macrophages; PAMPs; neutrophils - ANSWER -Answer: A
Section: Phagocytosis
Difficulty: 2
Hint: PRRs are found on antigen-presenting cells.
4. Which of the following is NOT entirely a response of the innate immune system?
, A. Phagocytosis by macrophages
B. Protection from infection by the skin
C. Low pH in the stomach
D. Antibody mediated complement activation
E. Microbial cell lysis by defensin - ANSWER -Answer: D
Section: Introduction
Difficulty: 2
Hint: What makes antibodies?
5. Which of these characteristics are adaptive?
A. Response takes several days to develop
B. Responds more quickly upon secondary exposure to pathogens
C. Pathogen receptors are extremely varied
D. Recognize broad classes of pathogens
E. A, B, and C - ANSWER -Answer: E
Section: Introduction
Difficulty: 1
Hint: Review Table 5-1.
6. Which of these characteristics are innate?
A. Found in all multicellular plants and animals
B. Receptors are encoded in the germline
C. Recognize broad classes of pathogens
D. Responds more quickly upon secondary exposure to pathogens
E. A, B, and C - ANSWER -Answer: E
Section: Introduction
Difficulty: 1
Hint: Review Table 5-1.
7. Why are many opsonins multimeric?
A. Because they are all derived from the same proto-opsonin
B. Because they bind repeating structures on pathogen surfaces
C. So that they can be regulated allosterically
D. Because they have to crosslink receptors on phagocytes in order for phagocytosis to
occur
E. Because one subunit binds pathogen and the other has enzymatic activity -
ANSWER -Answer: B
Section: Phagocytosis
Difficulty: 2
Hint: Multimeric receptors have several identical binding sites.
8. Which of the following are associated with damaged or dead cells?
