IMMUNOLOGY EXAM 3 - QUIZZES ON
CHAPTER 7, 8, 9 QUESTIONS WITH
COMPLETE ANSWERS
What is the surrogate for the alpha chain of the T cell receptor?
A. Ig-alpha
B. pT-alpha
C. CD3
D. VpreB/lambda5 - ANSWER -B. pT-alpha
Pre-T cells are also called double positve T cell when they start expressing CD4 and
CD8 molecules.
A. True
B. False - ANSWER -A. True
Positive selection is the process whereby a VERY LARGE subpopulation (about 98% of
T cells) is selected and signaled to mature further.
A. True
B. False - ANSWER -B. False
Negative selection deletes by apoptosis T cells whose antigen receptors bind too
strongly to the complexes of self peptides and self-MHC molecules presented by cells in
the thymus.
A. True
B. False - ANSWER -A. True
Having survived both positive and negative selection, the NOW mature T cells (aka
naïve T cells) do what ?
A. leave the thymus and die via apoptosis within a few hours.
B. stay in the thymus for antigen stimulation
C. leave the thymus in the blood and circulate through the secondary lymphoid organs.
D. stay in the thymus for development into effector T cells - ANSWER -C. leave the
thymus in the blood and circulate through the secondary lymphoid organs.
Antigen recognition by a naive T cell in the absence of co-stimulation leads to the T cell
becoming non-responsive.
A. True
B. False - ANSWER -A. True
Tcells develop in the _________________.
A. Lymph node
B. Thymus
C. heart
, D. Bone marrow - ANSWER -B. Thymus
Which cell type does NOT belong in the cortex of the thymus?
A. macrophages
B. dendritic cells
C. cortical epithelial cells
D. immature thymocytes - ANSWER -B. dendritic cells
Which cytokine important in initial development of T cells in the thymus?
A. IL-7
B. IL-10
C. IL-17
D. TNF-alpha - ANSWER -A. IL-7
T-cell development is driven initially in the thymus by the receptor____________.
A. Notch 1
B. CD34
C. CD3
D. IgM - ANSWER -A. Notch 1
α:β and gamma:delta T cells develop from a common double-negative T-cell progenitor.
A. True
B. False - ANSWER -A. True
Which antigen presenting cell is the best at presenting antigen (the most professional)
and can even stimulate naïve CD8 T cells strongly?
A. B-cells
B. T-cells
C. Macrophages
D. Dendritic cells - ANSWER -D. Dendritic cells
What is T- cell priming?
A. It is when T-cell are infected by microbes
B. It is when naive T-cells are activated by antigens
C. It is when T-cells drink a soda pop
D. It is when T-cell mature in the thymus - ANSWER -B. It is when naive T-cells are
activated by antigens
Mature dendritic cells like to hang out and present antigen to T-cells where?
A. bone marrow
B. blood
C. lymph nodes
D. skin - ANSWER -C. lymph nodes
Which of the following cell type is NOT a professional antigen presenting cell?
A. Macrophages
CHAPTER 7, 8, 9 QUESTIONS WITH
COMPLETE ANSWERS
What is the surrogate for the alpha chain of the T cell receptor?
A. Ig-alpha
B. pT-alpha
C. CD3
D. VpreB/lambda5 - ANSWER -B. pT-alpha
Pre-T cells are also called double positve T cell when they start expressing CD4 and
CD8 molecules.
A. True
B. False - ANSWER -A. True
Positive selection is the process whereby a VERY LARGE subpopulation (about 98% of
T cells) is selected and signaled to mature further.
A. True
B. False - ANSWER -B. False
Negative selection deletes by apoptosis T cells whose antigen receptors bind too
strongly to the complexes of self peptides and self-MHC molecules presented by cells in
the thymus.
A. True
B. False - ANSWER -A. True
Having survived both positive and negative selection, the NOW mature T cells (aka
naïve T cells) do what ?
A. leave the thymus and die via apoptosis within a few hours.
B. stay in the thymus for antigen stimulation
C. leave the thymus in the blood and circulate through the secondary lymphoid organs.
D. stay in the thymus for development into effector T cells - ANSWER -C. leave the
thymus in the blood and circulate through the secondary lymphoid organs.
Antigen recognition by a naive T cell in the absence of co-stimulation leads to the T cell
becoming non-responsive.
A. True
B. False - ANSWER -A. True
Tcells develop in the _________________.
A. Lymph node
B. Thymus
C. heart
, D. Bone marrow - ANSWER -B. Thymus
Which cell type does NOT belong in the cortex of the thymus?
A. macrophages
B. dendritic cells
C. cortical epithelial cells
D. immature thymocytes - ANSWER -B. dendritic cells
Which cytokine important in initial development of T cells in the thymus?
A. IL-7
B. IL-10
C. IL-17
D. TNF-alpha - ANSWER -A. IL-7
T-cell development is driven initially in the thymus by the receptor____________.
A. Notch 1
B. CD34
C. CD3
D. IgM - ANSWER -A. Notch 1
α:β and gamma:delta T cells develop from a common double-negative T-cell progenitor.
A. True
B. False - ANSWER -A. True
Which antigen presenting cell is the best at presenting antigen (the most professional)
and can even stimulate naïve CD8 T cells strongly?
A. B-cells
B. T-cells
C. Macrophages
D. Dendritic cells - ANSWER -D. Dendritic cells
What is T- cell priming?
A. It is when T-cell are infected by microbes
B. It is when naive T-cells are activated by antigens
C. It is when T-cells drink a soda pop
D. It is when T-cell mature in the thymus - ANSWER -B. It is when naive T-cells are
activated by antigens
Mature dendritic cells like to hang out and present antigen to T-cells where?
A. bone marrow
B. blood
C. lymph nodes
D. skin - ANSWER -C. lymph nodes
Which of the following cell type is NOT a professional antigen presenting cell?
A. Macrophages
