318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
LS3 QUESTIONS
1. Which of the following conditions is associated with increased blood levels of
unconjugated bilirubin?
A. None of the above.
B. Rotor syndrome.
C. Hemolysis.
D. Dubin-Johnson syndrome.
2. What is an advantage of the 5th generation of cephalosporins in comparison
with the 4th generation?
A. Active against Neisseria.
B. Extended spectrum against Enterobacteriaceae.
C. Active against Ps. Aerugionsa.
D. Active against Methicillin Resistant S. aureus-MRSA.
3. Which of the following neurotransmitters has inhibitory function in CNS?
A. Serotonin.
B. Norepinephrine.
C. Glutamate.
D. Yaminobutyric acid (GABA).
4. Residents are the strains:
A. That have an established niche at one of the many body sites, which they
occupy indefinitely.
B. That are acquired from environment and establish themselves briefly, but tend
to be excluded by competition from residents or by innate or immune defense
mechanism.
5. Elevated plasma levels of which of the following amino acids promotes
oxidative damage, inflammation, and endothelial dysfunction, and is an
independent risk factor for occlusive vascular disease?
A. Tryptophan.
B. Tyrosine.
C. Homocysteine.
D. Glutamate.
6. A 5 year old girl presents with malnutrition, bleeding gums and irritability. A
diagnosis of scurvy is made. Which of the following processes will be disturbed
in this patient?
A. Hydroxylation of tyrosine residues.
B. 2 Hydroxylation of tryptophan residues.
C. Hydroxylation of lysine residues.
D. Hydroxylation of glycine residues.
318_LS3_QUESTIONS.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.(ehttps://online2pdf.com/delete-header-and-footer-in-pdfxt)
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
,318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
7. Nucleotides are not composed of:
A. A five-carbon sugar, or pentose.
B. Aphosphate group.
C. Ahydrogen group.
D. Acyclic nitrogen base.
8. Nonsusceptible term applies when organisms are:
A. Not inhibited by clinically achievable concentrations of antimicrobial agent.
B. Inhibited by clinically achievable concentrations of antimicrobial agent.
9. The patient presents with frequent joint dislocations and a fragile, stretchy
skin. Diagnosis of Ehlers- Danlos syndrome is made. The condition results from
alteration of the structure, production or processing of one of the fibrous
proteins in the body. Which protein is it?
A. None of the above.
B. Elastin.
C. Collagen.
D. Fibrillin.
10. Transduction is governed by:
A. Bacterial chromosome genes.
B. Plasmid genes.
C. Bacteriophage genes.
11. Patient presents with displacement of the lens of the eye, skeletal
abnormalities and neurological deficits. Further examination shows increased
plasma levels of homocysteine. Which of the following enzymes is most likely
deficient in this patient?
A. Homogentisate oxidase.
B. Cystathione synthase.
C. Arginase.
D. DOPA decarboxylase.
12. Which of the following enzymes is NOT inhibited in lead poisoning?
A. AlA dehydrogenase.
B. Porphobillinogen deaminase.
C. Ferrochelatase.
13. An allele is:
A. One of several possible forms of a gene.
B. A homozygous genotype.
C. A heterozygous genotype.
D. Another word for a gene.
318_LS3_QUESTIONS.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.(ehttps://online2pdf.com/delete-header-and-footer-in-pdfxt)
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
,318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
14. ID 50- Infectious Dose that will:
A. Cause disease in 50% of inoculated test animals.
B. Kill 50% of experimentally inoculated test animal within a certain period of
time.
15. Therapeutic index (TI) for penicillin is >100, for genamicin is 10,
carbamazepine is - 0.1. Which of the above antibiotics would you recommend
to patient, if their susceptibility tests show the same positive results?
A. Penicillin.
B. Gentamicin.
C. Carbamazepine.
16. Which of the following is synthesized from tyrosine?
A. Dopamine.
B. Serotonin.
C. Acetylcholine.
D. Histamine.
17. To establish a successful and cost-effective screening program for detecting
heterozygous carriers of an autosomal recessive disease, all of the following
are essential, EXCEPT:
A. A high-risk population can be identified.
B. Genetic counseling is provided with the testing.
C. The screening test has a positive predictive value of 100% 4 The disease is
severe enough to be clinically significant.
18. Which of the following conditions is most associated with conjugated
hyperbilirubinemia?
A. None of the above.
B. Gilbert syndrome.
C. Hemolysis.
D. Obstruction of bile ducts.
19. Which of the following amino acids is involved in formation of high energy
compound that is the major methyl group donor in one carbon metabolism?
A. Alanine.
B. Tyrosine.
C. Methionine.
D. Tryptophan.
318_LS3_QUESTIONS.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.(ehttps://online2pdf.com/delete-header-and-footer-in-pdfxt)
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
, 318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
20. Which of the following statements describes Klinefelter's syndrome
accurately?
A. It is characterised by ambiguous genitalia at birth.
B. It occurs in a phenotypic female with 46,XY karyotype.
C. It is seen at higher frequency in males in prison than in the general population.
D. It is characterised by a 47,XXY karyotype with hypogonadism after puberty.
21. Name a macromolecule, cylindrical complex of proteins, whose stacked rings
form a central pore that harbors the active sites of proteolytic enzymes. Entry
into the core is regulated by the two outer rings that recognize
polyubiquitinated proteins.
A. Smooth endoplasmic reticulum.
B. Proteasome.
C. Rough endoplasmic reticulum.
D. Golgi apparatus.
22. Choose the incorrect statement about types of genetic diseases
A. Multifactorial disorders result from a combination of multiple genetic and
environmental causes.
B. Chromosome disorders include cystic fibrosis, sickle cell disease, and
hemophilia.
C. Disorders in which single genes are altered are termed mendelian conditions,
or single-gene disorders.
D. In chromosome disorders entire chromosomes are missing, duplicated, or
otherwise altered.
23. Choose the correct statement
A. Chromosome mutations- mutations that affect the number of chromosomes in
the cell.
B. Gene mutations- mutations that alter individual genes.
C. Multifactorial disorders- result from genetic mutations.
D. Genome mutations- mutations that alter the structure of individual
chromosomes.
24. A telomere-specific protein complex that protects DNA from degradation is
called:
A. Satellite.
B. T-loop.
C. Shelterin.
D. Replication bubble.
318_LS3_QUESTIONS.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.(ehttps://online2pdf.com/delete-header-and-footer-in-pdfxt)
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
LS3 QUESTIONS
1. Which of the following conditions is associated with increased blood levels of
unconjugated bilirubin?
A. None of the above.
B. Rotor syndrome.
C. Hemolysis.
D. Dubin-Johnson syndrome.
2. What is an advantage of the 5th generation of cephalosporins in comparison
with the 4th generation?
A. Active against Neisseria.
B. Extended spectrum against Enterobacteriaceae.
C. Active against Ps. Aerugionsa.
D. Active against Methicillin Resistant S. aureus-MRSA.
3. Which of the following neurotransmitters has inhibitory function in CNS?
A. Serotonin.
B. Norepinephrine.
C. Glutamate.
D. Yaminobutyric acid (GABA).
4. Residents are the strains:
A. That have an established niche at one of the many body sites, which they
occupy indefinitely.
B. That are acquired from environment and establish themselves briefly, but tend
to be excluded by competition from residents or by innate or immune defense
mechanism.
5. Elevated plasma levels of which of the following amino acids promotes
oxidative damage, inflammation, and endothelial dysfunction, and is an
independent risk factor for occlusive vascular disease?
A. Tryptophan.
B. Tyrosine.
C. Homocysteine.
D. Glutamate.
6. A 5 year old girl presents with malnutrition, bleeding gums and irritability. A
diagnosis of scurvy is made. Which of the following processes will be disturbed
in this patient?
A. Hydroxylation of tyrosine residues.
B. 2 Hydroxylation of tryptophan residues.
C. Hydroxylation of lysine residues.
D. Hydroxylation of glycine residues.
318_LS3_QUESTIONS.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.(ehttps://online2pdf.com/delete-header-and-footer-in-pdfxt)
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
,318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
7. Nucleotides are not composed of:
A. A five-carbon sugar, or pentose.
B. Aphosphate group.
C. Ahydrogen group.
D. Acyclic nitrogen base.
8. Nonsusceptible term applies when organisms are:
A. Not inhibited by clinically achievable concentrations of antimicrobial agent.
B. Inhibited by clinically achievable concentrations of antimicrobial agent.
9. The patient presents with frequent joint dislocations and a fragile, stretchy
skin. Diagnosis of Ehlers- Danlos syndrome is made. The condition results from
alteration of the structure, production or processing of one of the fibrous
proteins in the body. Which protein is it?
A. None of the above.
B. Elastin.
C. Collagen.
D. Fibrillin.
10. Transduction is governed by:
A. Bacterial chromosome genes.
B. Plasmid genes.
C. Bacteriophage genes.
11. Patient presents with displacement of the lens of the eye, skeletal
abnormalities and neurological deficits. Further examination shows increased
plasma levels of homocysteine. Which of the following enzymes is most likely
deficient in this patient?
A. Homogentisate oxidase.
B. Cystathione synthase.
C. Arginase.
D. DOPA decarboxylase.
12. Which of the following enzymes is NOT inhibited in lead poisoning?
A. AlA dehydrogenase.
B. Porphobillinogen deaminase.
C. Ferrochelatase.
13. An allele is:
A. One of several possible forms of a gene.
B. A homozygous genotype.
C. A heterozygous genotype.
D. Another word for a gene.
318_LS3_QUESTIONS.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.(ehttps://online2pdf.com/delete-header-and-footer-in-pdfxt)
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
,318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
14. ID 50- Infectious Dose that will:
A. Cause disease in 50% of inoculated test animals.
B. Kill 50% of experimentally inoculated test animal within a certain period of
time.
15. Therapeutic index (TI) for penicillin is >100, for genamicin is 10,
carbamazepine is - 0.1. Which of the above antibiotics would you recommend
to patient, if their susceptibility tests show the same positive results?
A. Penicillin.
B. Gentamicin.
C. Carbamazepine.
16. Which of the following is synthesized from tyrosine?
A. Dopamine.
B. Serotonin.
C. Acetylcholine.
D. Histamine.
17. To establish a successful and cost-effective screening program for detecting
heterozygous carriers of an autosomal recessive disease, all of the following
are essential, EXCEPT:
A. A high-risk population can be identified.
B. Genetic counseling is provided with the testing.
C. The screening test has a positive predictive value of 100% 4 The disease is
severe enough to be clinically significant.
18. Which of the following conditions is most associated with conjugated
hyperbilirubinemia?
A. None of the above.
B. Gilbert syndrome.
C. Hemolysis.
D. Obstruction of bile ducts.
19. Which of the following amino acids is involved in formation of high energy
compound that is the major methyl group donor in one carbon metabolism?
A. Alanine.
B. Tyrosine.
C. Methionine.
D. Tryptophan.
318_LS3_QUESTIONS.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.(ehttps://online2pdf.com/delete-header-and-footer-in-pdfxt)
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
, 318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
20. Which of the following statements describes Klinefelter's syndrome
accurately?
A. It is characterised by ambiguous genitalia at birth.
B. It occurs in a phenotypic female with 46,XY karyotype.
C. It is seen at higher frequency in males in prison than in the general population.
D. It is characterised by a 47,XXY karyotype with hypogonadism after puberty.
21. Name a macromolecule, cylindrical complex of proteins, whose stacked rings
form a central pore that harbors the active sites of proteolytic enzymes. Entry
into the core is regulated by the two outer rings that recognize
polyubiquitinated proteins.
A. Smooth endoplasmic reticulum.
B. Proteasome.
C. Rough endoplasmic reticulum.
D. Golgi apparatus.
22. Choose the incorrect statement about types of genetic diseases
A. Multifactorial disorders result from a combination of multiple genetic and
environmental causes.
B. Chromosome disorders include cystic fibrosis, sickle cell disease, and
hemophilia.
C. Disorders in which single genes are altered are termed mendelian conditions,
or single-gene disorders.
D. In chromosome disorders entire chromosomes are missing, duplicated, or
otherwise altered.
23. Choose the correct statement
A. Chromosome mutations- mutations that affect the number of chromosomes in
the cell.
B. Gene mutations- mutations that alter individual genes.
C. Multifactorial disorders- result from genetic mutations.
D. Genome mutations- mutations that alter the structure of individual
chromosomes.
24. A telomere-specific protein complex that protects DNA from degradation is
called:
A. Satellite.
B. T-loop.
C. Shelterin.
D. Replication bubble.
318_LS3_QUESTIONS.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
318_LS3_QUESTIONS.pdf.(ehttps://online2pdf.com/delete-header-and-footer-in-pdfxt)
318_LS3_QUESTIONS.pdf.pdfhttps://online2pdf.com/delete-header-and-footer-in-pdf
