NUR 210 EXAM 1: ADVANCED
PHARMACOLOGY FOR NURSING
QUESTIONS & ANSWERS (GALEN) 100%
GUARANTEE PASS
1. A patient with liver cirrhosis has a significantly low serum albumin level. When
administering a medication that is highly protein-bound, the nurse should expect which
physiological consequence?
A. Decreased drug distribution to the target tissues
B. An increased level of free, active drug in the bloodstream
C. Increased rate of renal excretion of the drug
D. A need to increase the dosage to achieve therapeutic effects
Answer: B
Conceptual Explanation: Low albumin means fewer binding sites for the drug. This
results in a higher concentration of ‘free’ or unbound drug, which is the pharmacologically
active form, increasing the risk of toxicity.
2. Which pharmacokinetic process is primarily affected by the ‘first-pass effect’ when a
medication is administered orally?
A. Distribution
,B. Excretion
C. Absorption
D. Metabolism
Answer: D
Conceptual Explanation: The first-pass effect refers to the metabolism of a drug by the
liver after it is absorbed from the GI tract but before it reaches the systemic circulation.
3. A drug has a half-life of 6 hours. If a dose of 400 mg is administered at 12:00 PM, what
amount of the drug will remain in the body at 12:00 AM the following day?
A. 100 mg
B. 200 mg
C. 50 mg
D. 25 mg
Answer: A
Conceptual Explanation: From 12 PM to 12 AM is 12 hours (two half-lives). After 6 hours,
200 mg remains. After another 6 hours, 100 mg remains.
4. When assessing a patient’s response to a newly prescribed medication, the nurse notes the
patient has developed an unexpected and opposite reaction to what was intended. This is
known as:
A. An idiosyncratic reaction
, B. An iatrogenic response
C. A paradoxical effect
D. Drug tolerance
Answer: C
Conceptual Explanation: A paradoxical effect is a response to a drug that is the opposite
of the expected therapeutic effect.
5. Which of the following is a characteristic of a drug with a narrow therapeutic index?
A. The drug is highly safe and requires little monitoring
B. The lethal dose is much higher than the effective dose
C. The difference between the therapeutic and toxic dose is small
D. The drug is metabolized rapidly by the kidneys
Answer: C
Conceptual Explanation: A narrow therapeutic index means that the concentration
required for therapeutic effect is very close to the concentration that causes toxicity,
requiring frequent monitoring.
6. A patient is prescribed a drug that is a known ‘enzyme inducer’ of the Cytochrome P450
system. The patient is also taking several other medications. The nurse should monitor for:
A. Increased therapeutic effects of the other medications
B. Reduced pharmacological effects of the other medications
PHARMACOLOGY FOR NURSING
QUESTIONS & ANSWERS (GALEN) 100%
GUARANTEE PASS
1. A patient with liver cirrhosis has a significantly low serum albumin level. When
administering a medication that is highly protein-bound, the nurse should expect which
physiological consequence?
A. Decreased drug distribution to the target tissues
B. An increased level of free, active drug in the bloodstream
C. Increased rate of renal excretion of the drug
D. A need to increase the dosage to achieve therapeutic effects
Answer: B
Conceptual Explanation: Low albumin means fewer binding sites for the drug. This
results in a higher concentration of ‘free’ or unbound drug, which is the pharmacologically
active form, increasing the risk of toxicity.
2. Which pharmacokinetic process is primarily affected by the ‘first-pass effect’ when a
medication is administered orally?
A. Distribution
,B. Excretion
C. Absorption
D. Metabolism
Answer: D
Conceptual Explanation: The first-pass effect refers to the metabolism of a drug by the
liver after it is absorbed from the GI tract but before it reaches the systemic circulation.
3. A drug has a half-life of 6 hours. If a dose of 400 mg is administered at 12:00 PM, what
amount of the drug will remain in the body at 12:00 AM the following day?
A. 100 mg
B. 200 mg
C. 50 mg
D. 25 mg
Answer: A
Conceptual Explanation: From 12 PM to 12 AM is 12 hours (two half-lives). After 6 hours,
200 mg remains. After another 6 hours, 100 mg remains.
4. When assessing a patient’s response to a newly prescribed medication, the nurse notes the
patient has developed an unexpected and opposite reaction to what was intended. This is
known as:
A. An idiosyncratic reaction
, B. An iatrogenic response
C. A paradoxical effect
D. Drug tolerance
Answer: C
Conceptual Explanation: A paradoxical effect is a response to a drug that is the opposite
of the expected therapeutic effect.
5. Which of the following is a characteristic of a drug with a narrow therapeutic index?
A. The drug is highly safe and requires little monitoring
B. The lethal dose is much higher than the effective dose
C. The difference between the therapeutic and toxic dose is small
D. The drug is metabolized rapidly by the kidneys
Answer: C
Conceptual Explanation: A narrow therapeutic index means that the concentration
required for therapeutic effect is very close to the concentration that causes toxicity,
requiring frequent monitoring.
6. A patient is prescribed a drug that is a known ‘enzyme inducer’ of the Cytochrome P450
system. The patient is also taking several other medications. The nurse should monitor for:
A. Increased therapeutic effects of the other medications
B. Reduced pharmacological effects of the other medications
