AOCNP (Advanced Oncology Certified
Nurse Practitioner) Practice Exam| YEAR
2026–2027 | Comprehensive 150-Question
Practice Test with Answers & Rationales| Pdf
Access ALREADY GRADED A+.
Domain 1: Cancer Continuum (28%)
1. A 55-year-old female with no personal history of cancer presents for a routine visit. Her
mother was diagnosed with breast cancer at age 48 and her sister at age 52. Which is the
most appropriate breast cancer screening recommendation?
A) Begin annual mammography at age 50
B) Begin annual mammography at age 40
C) Begin annual mammography and breast MRI at age 30
D) Begin annual mammography 10 years before the youngest affected relative's age of diagnosis
Answer: D
Rationale: For patients with a first-degree relative diagnosed with breast cancer before age 50,
screening should begin 10 years before the youngest affected relative's age of diagnosis, but not
before age 30. The youngest affected relative here is the sister diagnosed at 52, so screening
begins at age 42 .
2. Which genetic syndrome is associated with an increased risk of colorectal cancer and
requires early screening colonoscopy?
A) BRCA1 mutation
B) Lynch syndrome
C) Li-Fraumeni syndrome
D) Von Hippel-Lindau syndrome
Answer: B
Rationale: Lynch syndrome (hereditary nonpolyposis colorectal cancer) is associated with
significantly increased colorectal cancer risk. Screening colonoscopy typically begins at age 20-
25 or 2-5 years before the youngest affected relative .
,3. A patient with newly diagnosed non-small cell lung cancer undergoes biomarker testing.
Which biomarker predicts response to EGFR tyrosine kinase inhibitors?
A) ALK rearrangement
B) EGFR mutation
C) PD-L1 expression
D) KRAS mutation
Answer: B
Rationale: EGFR mutations (exon 19 deletion, exon 21 L858R) predict response to EGFR TKIs
such as osimertinib, erlotinib, and gefitinib .
4. The TNM staging system classifies cancer based on:
A) Tumor grade, nodal involvement, and metastasis
B) Tumor size/invasion, nodal involvement, and metastasis
C) Tumor type, nuclear grade, and mitotic rate
D) Tumor location, necrosis, and molecular markers
Answer: B
Rationale: TNM stands for Tumor (size/extent), Nodes (regional lymph node involvement), and
Metastasis (distant spread) .
5. Which performance status scale is commonly used in oncology to assess a patient's
functional capacity?
A) Glasgow Coma Scale
B) ECOG Performance Status
C) Braden Scale
D) Morse Fall Scale
Answer: B
Rationale: The Eastern Cooperative Oncology Group (ECOG) Performance Status scale ranges
from 0 (fully active) to 5 (dead) and guides treatment decisions .
6. A patient with stage II colon cancer has completed surgery. Which surveillance strategy is
recommended?
A) CT scans every 3 months for 5 years
B) CEA every 3-6 months for 5 years and colonoscopy at 1 year
C) PET scans annually for 3 years
D) No surveillance needed after surgery
Answer: B
Rationale: Post-treatment surveillance for colon cancer includes CEA every 3-6 months for 5
years and colonoscopy at 1 year, then per findings .
, 7. A patient with cancer is considering fertility preservation. Which option should be
discussed before initiating gonadotoxic chemotherapy?
A) Ovarian suppression with GnRH agonist
B) Embryo cryopreservation
C) Hormone replacement therapy
D) Oral contraceptive pills
Answer: B
Rationale: Embryo cryopreservation is an established fertility preservation method that requires
oocyte retrieval before chemotherapy. Sperm banking is the equivalent for male patients .
8. Which at-risk population has disproportionately higher cancer mortality rates due to
barriers in screening and treatment access?
A) Insured patients with private insurance
B) Patients in rural and underserved communities
C) Patients with family history of cancer
D) Patients with early-stage diagnosis
Answer: B
Rationale: Rural and underserved populations experience disparities in cancer screening,
diagnosis, and treatment, leading to higher mortality .
9. A survivorship care plan should include:
A) Only the cancer diagnosis and treatment dates
B) Surveillance recommendations, late effects monitoring, and wellness strategies
C) Chemotherapy dosing calculations
D) Surgical procedure notes only
Answer: B
Rationale: Survivorship care plans include surveillance for recurrence, screening for new
cancers, monitoring for late effects, and health promotion strategies .
10. Which hereditary cancer syndrome is associated with BRCA1/BRCA2 mutations?
A) Hereditary breast and ovarian cancer syndrome
B) Lynch syndrome
C) Familial adenomatous polyposis
D) Multiple endocrine neoplasia
Answer: A
Rationale: BRCA1 and BRCA2 mutations significantly increase the risk of breast and ovarian
cancers, as well as pancreatic and prostate cancers .
Nurse Practitioner) Practice Exam| YEAR
2026–2027 | Comprehensive 150-Question
Practice Test with Answers & Rationales| Pdf
Access ALREADY GRADED A+.
Domain 1: Cancer Continuum (28%)
1. A 55-year-old female with no personal history of cancer presents for a routine visit. Her
mother was diagnosed with breast cancer at age 48 and her sister at age 52. Which is the
most appropriate breast cancer screening recommendation?
A) Begin annual mammography at age 50
B) Begin annual mammography at age 40
C) Begin annual mammography and breast MRI at age 30
D) Begin annual mammography 10 years before the youngest affected relative's age of diagnosis
Answer: D
Rationale: For patients with a first-degree relative diagnosed with breast cancer before age 50,
screening should begin 10 years before the youngest affected relative's age of diagnosis, but not
before age 30. The youngest affected relative here is the sister diagnosed at 52, so screening
begins at age 42 .
2. Which genetic syndrome is associated with an increased risk of colorectal cancer and
requires early screening colonoscopy?
A) BRCA1 mutation
B) Lynch syndrome
C) Li-Fraumeni syndrome
D) Von Hippel-Lindau syndrome
Answer: B
Rationale: Lynch syndrome (hereditary nonpolyposis colorectal cancer) is associated with
significantly increased colorectal cancer risk. Screening colonoscopy typically begins at age 20-
25 or 2-5 years before the youngest affected relative .
,3. A patient with newly diagnosed non-small cell lung cancer undergoes biomarker testing.
Which biomarker predicts response to EGFR tyrosine kinase inhibitors?
A) ALK rearrangement
B) EGFR mutation
C) PD-L1 expression
D) KRAS mutation
Answer: B
Rationale: EGFR mutations (exon 19 deletion, exon 21 L858R) predict response to EGFR TKIs
such as osimertinib, erlotinib, and gefitinib .
4. The TNM staging system classifies cancer based on:
A) Tumor grade, nodal involvement, and metastasis
B) Tumor size/invasion, nodal involvement, and metastasis
C) Tumor type, nuclear grade, and mitotic rate
D) Tumor location, necrosis, and molecular markers
Answer: B
Rationale: TNM stands for Tumor (size/extent), Nodes (regional lymph node involvement), and
Metastasis (distant spread) .
5. Which performance status scale is commonly used in oncology to assess a patient's
functional capacity?
A) Glasgow Coma Scale
B) ECOG Performance Status
C) Braden Scale
D) Morse Fall Scale
Answer: B
Rationale: The Eastern Cooperative Oncology Group (ECOG) Performance Status scale ranges
from 0 (fully active) to 5 (dead) and guides treatment decisions .
6. A patient with stage II colon cancer has completed surgery. Which surveillance strategy is
recommended?
A) CT scans every 3 months for 5 years
B) CEA every 3-6 months for 5 years and colonoscopy at 1 year
C) PET scans annually for 3 years
D) No surveillance needed after surgery
Answer: B
Rationale: Post-treatment surveillance for colon cancer includes CEA every 3-6 months for 5
years and colonoscopy at 1 year, then per findings .
, 7. A patient with cancer is considering fertility preservation. Which option should be
discussed before initiating gonadotoxic chemotherapy?
A) Ovarian suppression with GnRH agonist
B) Embryo cryopreservation
C) Hormone replacement therapy
D) Oral contraceptive pills
Answer: B
Rationale: Embryo cryopreservation is an established fertility preservation method that requires
oocyte retrieval before chemotherapy. Sperm banking is the equivalent for male patients .
8. Which at-risk population has disproportionately higher cancer mortality rates due to
barriers in screening and treatment access?
A) Insured patients with private insurance
B) Patients in rural and underserved communities
C) Patients with family history of cancer
D) Patients with early-stage diagnosis
Answer: B
Rationale: Rural and underserved populations experience disparities in cancer screening,
diagnosis, and treatment, leading to higher mortality .
9. A survivorship care plan should include:
A) Only the cancer diagnosis and treatment dates
B) Surveillance recommendations, late effects monitoring, and wellness strategies
C) Chemotherapy dosing calculations
D) Surgical procedure notes only
Answer: B
Rationale: Survivorship care plans include surveillance for recurrence, screening for new
cancers, monitoring for late effects, and health promotion strategies .
10. Which hereditary cancer syndrome is associated with BRCA1/BRCA2 mutations?
A) Hereditary breast and ovarian cancer syndrome
B) Lynch syndrome
C) Familial adenomatous polyposis
D) Multiple endocrine neoplasia
Answer: A
Rationale: BRCA1 and BRCA2 mutations significantly increase the risk of breast and ovarian
cancers, as well as pancreatic and prostate cancers .
