ONS ONCC CHEMOTHERAPY
IMMUNOTHERAPY CERTIFICATE EXAM REVIEW
SOLVED QUESTIONS WITH VERIFIED ANSWERS
◉ 3 subcategories of alkylating agents:
Answer: 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still
termed alkylating agents as they work similarly)
3. Nitrosoureas
◉ Most common subcategory of alkylating agents:
Answer: Nitrogen mustards
◉ Common alkylating agents:
Answer: Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
◉ Common platinum-based agents:
Answer: Cisplatin (Platinol)
Carboplatin (Paraplatin)
,◉ What is unique about nitrosoureas agents?
Answer: Able to cross the blood-brain barrier; can be effective in
treating some brain tumors
◉ Common nitrosoureas agents:
Answer: Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
◉ Hypersensitivity can occur with late doses of:
Answer: Carboplatin
◉ These agents are typically categorized as highly emetogenic:
Answer: 1. Alkylating agents
2. Nitrosoureas
◉ Pre-administration labs for alkylating agents and nitrosoureas:
Answer: BUN
Creatinine
CBC w/ diff
, ◉ What is the medication Mesna used for?
Answer: Bladder protectant with administration of
cyclophosphamide or ifosfamide
◉ Instruct pts receiving ________ to avoid exposure to cold air and
consuming cold fluids for 3-4 days following treatment
Answer: Oxaliplatin
◉ How do antimetabolites function?
Answer: By blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
◉ Antimetabolites work in the ___ phase.
Answer: S
◉ What types of cells are best affected by antimetabolites?
Answer: Cells with high division rates
◉ Common side effects of antimetabolites:
Answer: Myelosuppression
GI toxicities
Photosensitivity
IMMUNOTHERAPY CERTIFICATE EXAM REVIEW
SOLVED QUESTIONS WITH VERIFIED ANSWERS
◉ 3 subcategories of alkylating agents:
Answer: 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still
termed alkylating agents as they work similarly)
3. Nitrosoureas
◉ Most common subcategory of alkylating agents:
Answer: Nitrogen mustards
◉ Common alkylating agents:
Answer: Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
◉ Common platinum-based agents:
Answer: Cisplatin (Platinol)
Carboplatin (Paraplatin)
,◉ What is unique about nitrosoureas agents?
Answer: Able to cross the blood-brain barrier; can be effective in
treating some brain tumors
◉ Common nitrosoureas agents:
Answer: Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
◉ Hypersensitivity can occur with late doses of:
Answer: Carboplatin
◉ These agents are typically categorized as highly emetogenic:
Answer: 1. Alkylating agents
2. Nitrosoureas
◉ Pre-administration labs for alkylating agents and nitrosoureas:
Answer: BUN
Creatinine
CBC w/ diff
, ◉ What is the medication Mesna used for?
Answer: Bladder protectant with administration of
cyclophosphamide or ifosfamide
◉ Instruct pts receiving ________ to avoid exposure to cold air and
consuming cold fluids for 3-4 days following treatment
Answer: Oxaliplatin
◉ How do antimetabolites function?
Answer: By blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
◉ Antimetabolites work in the ___ phase.
Answer: S
◉ What types of cells are best affected by antimetabolites?
Answer: Cells with high division rates
◉ Common side effects of antimetabolites:
Answer: Myelosuppression
GI toxicities
Photosensitivity
