ONS CHEMOTHERAPY IMMUNOTHERAPY
CERTIFICATE TEST BANK UPDATED
COMPLETE QUESTIONS WITH ACCURATE
ANSWERS
●● 3 steps of interphase:
Answer: First growth phase (G1)
Synthesis phase (S phase)
Second growth phase (G2)
●● 4 phases of mitosis:
Answer: Prophase
Metaphase
Anaphase
Telophase
●● Innate immunity:
Answer: Non-specific response, either:
1. Barrier (skin, mucous membranes, flora of skin/gut)
2. Cellular components (phagocytes, natural killer cells, granulocytes,
macrophages)
,●● Adaptive immunity:
Answer: Follows innate immunity if unsuccessful. Memory immunity,
including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon T cells)
3. Regulatory T -cells (prevent autoimmune reactions and limit
inflammatory responses)
●● Define mutations
Answer: Variations in the nucleotide sequence of a gene
●● 3 main goals of treatment:
Answer: Cure
Control
Palliation
●● Define neoadjuvant therapy
Answer: Treatment is given prior to surgery to shrink the tumor
●● Define adjuvant therapy
Answer: Additional cancer treatment given after the primary treatment to
lower the risk that the cancer reoccur
,●● Define conditioning/preparative therapy
Answer: Treatments used to prepare a patient for stem cell
transplantation
●● 2 types of conditioning therapies:
Answer: Myeloablative
Nonmyeloablative
●● Define dose density
Answer: Drug dose per unit of time
●● Define dose intensity
Answer: Amount of drug delivered over time
●● How is relative dose intensity (RDI) calculated?
Answer: By comparing the dose that the patient ACTUALLY received to
the planned dose of the standard regimen
●● How do alkylating agents work?
Answer: By causing a break in the DNA helix strand, interfering with
DNA replication and causing cell death
●● 3 subcategories of alkylating agents:
, Answer: 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed
alkylating agents as they work similarly)
3. Nitrosoureas
●● Most common subcategory of alkylating agents:
Answer: Nitrogen mustards
●● Common alkylating agents:
Answer: Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
●● Common platinum-based agents:
Answer: Cisplatin (Platinol)
Carboplatin (Paraplatin)
●● What is unique about nitrosoureas agents?
Answer: Able to cross the blood-brain barrier; can be effective in
treating some brain tumors
●● Common nitrosoureas agents:
Answer: Carmustine (BiCNU)
CERTIFICATE TEST BANK UPDATED
COMPLETE QUESTIONS WITH ACCURATE
ANSWERS
●● 3 steps of interphase:
Answer: First growth phase (G1)
Synthesis phase (S phase)
Second growth phase (G2)
●● 4 phases of mitosis:
Answer: Prophase
Metaphase
Anaphase
Telophase
●● Innate immunity:
Answer: Non-specific response, either:
1. Barrier (skin, mucous membranes, flora of skin/gut)
2. Cellular components (phagocytes, natural killer cells, granulocytes,
macrophages)
,●● Adaptive immunity:
Answer: Follows innate immunity if unsuccessful. Memory immunity,
including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon T cells)
3. Regulatory T -cells (prevent autoimmune reactions and limit
inflammatory responses)
●● Define mutations
Answer: Variations in the nucleotide sequence of a gene
●● 3 main goals of treatment:
Answer: Cure
Control
Palliation
●● Define neoadjuvant therapy
Answer: Treatment is given prior to surgery to shrink the tumor
●● Define adjuvant therapy
Answer: Additional cancer treatment given after the primary treatment to
lower the risk that the cancer reoccur
,●● Define conditioning/preparative therapy
Answer: Treatments used to prepare a patient for stem cell
transplantation
●● 2 types of conditioning therapies:
Answer: Myeloablative
Nonmyeloablative
●● Define dose density
Answer: Drug dose per unit of time
●● Define dose intensity
Answer: Amount of drug delivered over time
●● How is relative dose intensity (RDI) calculated?
Answer: By comparing the dose that the patient ACTUALLY received to
the planned dose of the standard regimen
●● How do alkylating agents work?
Answer: By causing a break in the DNA helix strand, interfering with
DNA replication and causing cell death
●● 3 subcategories of alkylating agents:
, Answer: 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed
alkylating agents as they work similarly)
3. Nitrosoureas
●● Most common subcategory of alkylating agents:
Answer: Nitrogen mustards
●● Common alkylating agents:
Answer: Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
●● Common platinum-based agents:
Answer: Cisplatin (Platinol)
Carboplatin (Paraplatin)
●● What is unique about nitrosoureas agents?
Answer: Able to cross the blood-brain barrier; can be effective in
treating some brain tumors
●● Common nitrosoureas agents:
Answer: Carmustine (BiCNU)
