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WGU D027 Study Guide | Latest 2025/2026 Comprehensive Exam Notes and Review

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Master essential WGU D027 concepts with this comprehensive study guide covering genetics, cardiovascular disorders, heart failure, ischemic heart disease, respiratory diseases, endocrine disorders, chronic kidney disease, pharmacology, diabetes management, thyroid conditions, mental health, social determinants of health, autoimmune disorders, gastrointestinal diseases, and evidence-based treatment guidelines. This organized review resource is ideal for exam preparation, course revision, self-assessment, and strengthening clinical reasoning skills needed for success in WGU D027 assessments and examinations.

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WGU D027 Study Guide
WGU D027 2026-2027 Study Guide
Study online at https://quizlet.com/_98yfxd

1. Autosomal Dominant 1 parent has, 50% change of child having

2. Autosomal Recessive Both parents are carriers, 25% change of child having, 50%
chance child is a carrier.

3. Cystic Fibrosis affects pancreas causing secretions in lungs

4. 21st Trisomy Down Syndrome

5. Klinefelter Syndrome (XXY) male has extra X, female like qualities

6. Turner Syndrome Missing X in females

7. Alpha Thalassemia inherited blood disorder; mild to severe anemia

8. Beta Thallasemia low hemoglobin; contraindicated medication ferrous sul-
fate

9. Prevalence Risk proportion of the population affected at a certain time

10. Incidence rate number of new cases divided by population

11. Innate immunity inflammation; increased vascular permeability

12. B&T lymphocytes immune response

13. primary malignant tumor lack of organization of cells

14. glucocorticoids used in combination with other agent to treat lymphoid
tissue (leukemia). glucocorticoids are directly toxic to lym-
phoid tissues.

15. Selective estrogen receptor for hormone receptor positive and advanced breast cancer.
modulators (SERM) (Tamoxifin reduces risk and recurrence risk)





, WGU D027 Study Guide
Study online at https://quizlet.com/_98yfxd
16. Heart failure impairment of the ventricle to fill with or eject blood; heart
cannot meet metabolic need of the body.

17. CHF heart cannot keep up with metabolic needs; volume over-
load in pulmonary area

18. Left Ventricular Dysfunction reduced ejection fraction; ventricle having issue ejecting
blood.

19. normal ejection fraction 55 - 60 % (blood pumped out with each heartbeat)

20. Ejection fraction of 50% - re- preserved
duced or preserved?

21. Diastolic CHF preserved ejection fraction, problem is with filling

22. Systolic CHF reduced ejection fraction, problem is with ejecting

23. Left sided CHF pulmonary (JVD, fluid volume overload, rails, S-3 murmurs)
** #1 cause of Right sided CHF

24. BNP gold standard lab test to diagnose CHF

25. Echocardiogram Diagnostic tool, evaluates heart structure and function

26. At Risk for HF - Stage A no structural heart disease or symptoms of heart failure

27. Stage A HF co-morbidities htn, atherosclerotic disease, diabetes, metabolic syndrome,
patients using cardiotoxins with family history

28. Therapy goals of stage A HF treat htn, encourage smoking cessation, encourage reg-
ular exercise, treat lipid disorders, discourage alcohol in-
take/drug use, control metabolic syndrome
Meds: ACEI or Angiotensin II RB for vascular disease or
diabetes (avapro, losartan, benicar, diovan, etc)



, WGU D027 Study Guide
Study online at https://quizlet.com/_98yfxd


29. At Risk for HF - Stage B structural heart disease but no symptoms of heart failure

30. Stage B HF co-morbidities previous MI, LV remodeling with LV hypertrophy and low EF,
asymptomatic valvular disease

31. Therapy goals of Stage B HF Meds: ACEI or ARB, Beta-blockers, inplantable defibrillators

32. Stage C heart failure structural heart disease with prior or current symptoms of
HF

33. Presentation of Stage C HF known structural heart disease and shortness of breath and
fatigue, reduced exercise tolerance

34. Therapy for Stage C HF dietary salt restriction, MEDS: diuretic, ACEI, beta blockers.
Some patients: aldosterone antagonist, ARBs, digitalis, hy-
dralazine/nitrates, biventricular pacing, inplantable defib-
rillators

35. Stage D heart failure refractory HF requiring specialized interventions

36. Presentation of Stage D HF marked symptoms at rest despite maximal medical therapy
(recurrently hospitalized or cannot be safely discharged
without specialized interventions)

37. Therapy goals for Stage D HF compassionate end-of-life care/hospice, extraordinary
measures ,heart transplant, chronic inotropes, permanent
mechanical support, experimental drugs or surgery

38. Ischemic heart Disease (CAD, chest discomfort, pain in neck/jaw/chest (crushing,
MI) presentation squeezing, sharp), pain worse with exertion (demand re-
quirement is higher), abnormal heart sounds, hypoxia, ar-
rhythmias (afib, ST elevation)

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