NU 578 Pharm Adv. Practice Nurses Unit 1 Questions and Answers

NU 578 Pharm Adv. Practice Nurses Unit 1 Questions and Answers


Question 1.
Pharmacokinetics Absorption, Distribution, Metabolism, Excretion What populations are
vulnerable? P13

Correct Answer: what the body does to the drug newborns cannot metabolize
drugs very efficiently until about a year of age. The elderly are vulnerable to
adverse drug effects because they cannot excrete drugs efficiently. How are
these changes monitored? Absorption of drugs takes into account
dosing—specifically the different routes and considerations like the first pass
effect and enterohepatic circulation. Distribution considers biologic membranes,
blood flow and protein binding—any of which may be affected in a patient in a
disease state (or with advancing age....or in pregnancy).


Question 2.
CYP450 characteristics, induction, inhibition p17-18

Correct Answer: Most metabolism is done in the liver by this enzyme,
cytochrome family of 12. 3 metabolism drugs while 9 metabolize endogenous.


Question 3.
P-glycoprotein p14

Correct Answer: PGP transport protein


Question 4.
Pediatric/infant populations and PK effects p18

Correct Answer: Liver not developed until one year, unable to metabolize drugs
the same way


Question 5.
Geriatric populations and PK effects p18 p61

Correct Answer: Slow drug metabolism


Question 6.
Blood brain barrier (BBB) p16

Correct Answer: Prevents passage of drugs; not developed in 1s year of life


Question 7.
Effects of renal function on drug persistence in the body

Correct Answer:


Question 8.

, Effectors of drug distribution (protein levels, decreased cardiac function, blood-brain
barrier, placental barrier)

Correct Answer:


Question 9.
Effectors of drug absorption p15

Correct Answer:


Question 10.
How do drugs cross membranes? What things influence this? What do polarity and charge
(ionizations) have to do with drugs crossing membranes (or not crossing them)?

Correct Answer: P13-15


Question 11.
What is the first-pass effect? P18

Correct Answer: Rapid hepatic inactivation of oral drugs


Question 12.
Grapefruit juice effects p32

Correct Answer:


Question 13.
Pharmacodynamics p22

Correct Answer:


Question 14.
Characteristics of agonists/antagonists

Correct Answer:


Question 15.
What are characteristics of agonists and antagonists? Partial agonists?

Correct Answer:


Question 16.
What is the advantage of a drug with a high therapeutic index?

Correct Answer: P28


Question 17.
What is P-glycoprotein and how can it influence drug-drug interactions?