NUR 378 EXAM 6 Questions with Verified
Correct Answers
Dermatologic Drugs
Antiacne: Tretinoin
Antifungal: Clotrimazole, Miconazole
Antipruritics: Glucocorticoids - hydrocortisone, triamcinolone
Antipsoriatic: Tazarotene
Tretinoin MOA
MOA:
- Stimulates the turnover of epidermal cells, which results in skin peeling
- It helps the skin heal from sun damage by making more fibroblasts → the cells that repair
tissue → increasing collagen → strengthens and rebuilds the skin
Tretinoin
THERAPEUTIC USE:
- Acne (acne vulgaris)
- Structural changes associated with sun damage such as wrinkling, hyperpigmentation, and
roughness
ROUTES:
- Cream
- Gel
- Liquid
ADVERSE EFFECTS:
,- Local anti-inflammatory affects
- Red and edematous blisters
- Crusted or dry skin
- Temporary alterations in pigmentation
- Severe sunburn
INTERACTIONS:
- Benzoyl peroxide, salicylic acid, exfoliants, or alcohol-based can increase redness, peeling,
and irritation when used with tretinoin
- Photosensitizing products or medications (like doxycycline or other tetracyclines) can make
skin even more sensitive to the sun, adding to tretinoin's own photosensitivity risk
- Waxing procedures
Clotrimazole, Miconazole
Drug Class: Antifungal
Pharmacological Class: Azole
Miconazole MOA
Miconazole inhibits the growth of several fungi, including dermatophytes and yeast, as well
as gram-positive bacteria
Clotrimazole MOA
- Clotrimazole and Miconazole inhibit the growth of dermatophytes and yeast
- ↓ integrity of fungal cell wall
Miconazole
, THERAPEUTIC USE:
Commonly used to treat dermatophytoses, superficial mycoses, cutaneous candidiasis, and
vulvovaginal candidiasis
ROUTES:
- Available in topical over-the-counter and prescription products
- Forms include aerosol spray, powder, cream, and vaginal preparations
ADVERSE EFFECTS:
- Irritation
- Stinging
- Redness
- Itching
- Dryness
- Peeling
INTERACTIONS:
Miconazole has more interactions than clotrimazole because it inhibits CYP450 enzymes
- Warfarin → Increased anticoagulant effect → high bleeding risk (major interaction)
- Oral hypoglycemics (sulfonylureas) → May increase risk of hypoglycemia
- Phenytoin → Can increase phenytoin levels and cause toxicity
Clotrimazole
THERAPEUTIC USE:
- Used for the treatment of oropharyngeal candidiasis (thrush)
- Treats dermatophytoses (e.g., athlete's foot), superficial mycoses, and vulvovaginal
Correct Answers
Dermatologic Drugs
Antiacne: Tretinoin
Antifungal: Clotrimazole, Miconazole
Antipruritics: Glucocorticoids - hydrocortisone, triamcinolone
Antipsoriatic: Tazarotene
Tretinoin MOA
MOA:
- Stimulates the turnover of epidermal cells, which results in skin peeling
- It helps the skin heal from sun damage by making more fibroblasts → the cells that repair
tissue → increasing collagen → strengthens and rebuilds the skin
Tretinoin
THERAPEUTIC USE:
- Acne (acne vulgaris)
- Structural changes associated with sun damage such as wrinkling, hyperpigmentation, and
roughness
ROUTES:
- Cream
- Gel
- Liquid
ADVERSE EFFECTS:
,- Local anti-inflammatory affects
- Red and edematous blisters
- Crusted or dry skin
- Temporary alterations in pigmentation
- Severe sunburn
INTERACTIONS:
- Benzoyl peroxide, salicylic acid, exfoliants, or alcohol-based can increase redness, peeling,
and irritation when used with tretinoin
- Photosensitizing products or medications (like doxycycline or other tetracyclines) can make
skin even more sensitive to the sun, adding to tretinoin's own photosensitivity risk
- Waxing procedures
Clotrimazole, Miconazole
Drug Class: Antifungal
Pharmacological Class: Azole
Miconazole MOA
Miconazole inhibits the growth of several fungi, including dermatophytes and yeast, as well
as gram-positive bacteria
Clotrimazole MOA
- Clotrimazole and Miconazole inhibit the growth of dermatophytes and yeast
- ↓ integrity of fungal cell wall
Miconazole
, THERAPEUTIC USE:
Commonly used to treat dermatophytoses, superficial mycoses, cutaneous candidiasis, and
vulvovaginal candidiasis
ROUTES:
- Available in topical over-the-counter and prescription products
- Forms include aerosol spray, powder, cream, and vaginal preparations
ADVERSE EFFECTS:
- Irritation
- Stinging
- Redness
- Itching
- Dryness
- Peeling
INTERACTIONS:
Miconazole has more interactions than clotrimazole because it inhibits CYP450 enzymes
- Warfarin → Increased anticoagulant effect → high bleeding risk (major interaction)
- Oral hypoglycemics (sulfonylureas) → May increase risk of hypoglycemia
- Phenytoin → Can increase phenytoin levels and cause toxicity
Clotrimazole
THERAPEUTIC USE:
- Used for the treatment of oropharyngeal candidiasis (thrush)
- Treats dermatophytoses (e.g., athlete's foot), superficial mycoses, and vulvovaginal
