NR 546 ADVANCED
PSYCHOPHARMACOLOGY EXAM
REVIEW QUESTIONS & ANSWERS
(CHAMBERLAIN) 100% GUARANTEE
PASS
1. Which cytochrome P450 enzyme is primarily responsible for the metabolism of
approximately 25% of all psychotropic medications, including many SSRIs and beta-blockers?
A. CYP3A4
B. CYP2C19
C. CYP1A2
D. CYP2D6
Answer: D
Conceptual Explanation: CYP2D6 is highly polymorphic and metabolizes a significant
portion of antidepressants, antipsychotics, and beta-blockers.
2. A patient taking Clozapine presents with a sudden onset of high fever, muscle rigidity, and
tachycardia. What is the most likely diagnosis?
A. Serotonin Syndrome
B. Anticholinergic Toxicity
,C. Agranulocytosis
D. Neuroleptic Malignant Syndrome (NMS)
Answer: D
Conceptual Explanation: NMS is a life-threatening reaction to antipsychotic drugs,
characterized by fever, ‘lead-pipe’ rigidity, autonomic instability, and altered mental status.
3. In the mesolimbic pathway, what is the effect of excessive dopamine activity?
A. Cognitive impairment
B. Positive symptoms of schizophrenia
C. Negative symptoms of schizophrenia
D. Extrapyramidal symptoms
Answer: B
Conceptual Explanation: Hyperactivity of dopamine in the mesolimbic pathway is
associated with positive symptoms like hallucinations and delusions.
4. Which antidepressant is contraindicated in patients with a history of seizure disorders or
eating disorders?
A. Fluoxetine
B. Sertraline
C. Venlafaxine
, D. Bupropion
Answer: D
Conceptual Explanation: Bupropion lowers the seizure threshold, especially in patients
with bulimia or anorexia nervosa due to potential electrolyte imbalances.
5. Which neurotransmitter is primarily targeted to treat Alzheimer’s disease by inhibiting
acetylcholinesterase?
A. Glutamate
B. Norepinephrine
C. Dopamine
D. Acetylcholine
Answer: D
Conceptual Explanation: Donepezil and similar drugs work by preventing the breakdown
of acetylcholine, which is deficient in Alzheimer’s disease.
6. What is the mechanism of action of Memantine in treating moderate to severe
Alzheimer’s?
A. NMDA receptor antagonist
B. SSRI
C. GABA receptor agonist
D. D2 receptor antagonist
PSYCHOPHARMACOLOGY EXAM
REVIEW QUESTIONS & ANSWERS
(CHAMBERLAIN) 100% GUARANTEE
PASS
1. Which cytochrome P450 enzyme is primarily responsible for the metabolism of
approximately 25% of all psychotropic medications, including many SSRIs and beta-blockers?
A. CYP3A4
B. CYP2C19
C. CYP1A2
D. CYP2D6
Answer: D
Conceptual Explanation: CYP2D6 is highly polymorphic and metabolizes a significant
portion of antidepressants, antipsychotics, and beta-blockers.
2. A patient taking Clozapine presents with a sudden onset of high fever, muscle rigidity, and
tachycardia. What is the most likely diagnosis?
A. Serotonin Syndrome
B. Anticholinergic Toxicity
,C. Agranulocytosis
D. Neuroleptic Malignant Syndrome (NMS)
Answer: D
Conceptual Explanation: NMS is a life-threatening reaction to antipsychotic drugs,
characterized by fever, ‘lead-pipe’ rigidity, autonomic instability, and altered mental status.
3. In the mesolimbic pathway, what is the effect of excessive dopamine activity?
A. Cognitive impairment
B. Positive symptoms of schizophrenia
C. Negative symptoms of schizophrenia
D. Extrapyramidal symptoms
Answer: B
Conceptual Explanation: Hyperactivity of dopamine in the mesolimbic pathway is
associated with positive symptoms like hallucinations and delusions.
4. Which antidepressant is contraindicated in patients with a history of seizure disorders or
eating disorders?
A. Fluoxetine
B. Sertraline
C. Venlafaxine
, D. Bupropion
Answer: D
Conceptual Explanation: Bupropion lowers the seizure threshold, especially in patients
with bulimia or anorexia nervosa due to potential electrolyte imbalances.
5. Which neurotransmitter is primarily targeted to treat Alzheimer’s disease by inhibiting
acetylcholinesterase?
A. Glutamate
B. Norepinephrine
C. Dopamine
D. Acetylcholine
Answer: D
Conceptual Explanation: Donepezil and similar drugs work by preventing the breakdown
of acetylcholine, which is deficient in Alzheimer’s disease.
6. What is the mechanism of action of Memantine in treating moderate to severe
Alzheimer’s?
A. NMDA receptor antagonist
B. SSRI
C. GABA receptor agonist
D. D2 receptor antagonist
