AOCNP EXAM REVIEW QUESTIONS &
VERIFIED ANSWERS (A+ GUARANTEE)
2026/2027
1. A patient with metastatic melanoma is identified as having a BRAF V600E mutation. Which
of the following is the most appropriate initial targeted therapy combination?
A. Pembrolizumab and Ipilimumab
B. Dabrafenib and Trametinib
C. Vemurafenib and Rituximab
D. Olaparib and Bevacizumab
Answer: B
Conceptual Explanation: Dabrafenib is a BRAF inhibitor and Trametinib is a MEK
inhibitor. The combination is standard for BRAF V600E-mutated melanoma to delay the
onset of resistance.
2. Which of the following electrolyte abnormalities is characteristic of Tumor Lysis Syndrome
(TLS)?
A. Hypercalcemia and Hypokalemia
B. Hypouricemia and Hypermagnesemia
C. Hyperuricemia, Hyperphosphatemia, and Hyperkalemia
,D. Hyponatremia and Hypophosphatemia
Answer: C
Conceptual Explanation: TLS involves the rapid release of intracellular contents, leading
to high levels of uric acid, potassium, and phosphorus, which subsequently causes
hypocalcemia.
3. An oncology NP is managing a patient on Pembrolizumab who presents with Grade 2
immune-related pneumonitis. What is the recommended management?
A. Continue Pembrolizumab and observe
B. Permanently discontinue Pembrolizumab immediately
C. Withhold therapy and initiate 1-2 mg/kg/day of prednisone
D. Administer prophylactic antibiotics and resume therapy next week
Answer: C
Conceptual Explanation: For Grade 2 pneumonitis, immunotherapy should be withheld,
and corticosteroids (prednisone 1-2 mg/kg/day) should be started. Therapy may be
resumed only if symptoms resolve to Grade 0-1 after a taper.
4. According to the USPSTF guidelines updated for 2021/2022, what is the age range and
smoking history required for annual low-dose CT lung cancer screening?
A. Ages 45-75 with a 15 pack-year history
B. Ages 50-80 with a 30 pack-year history
, C. Ages 50-80 with a 20 pack-year history
D. Ages 55-80 with a 30 pack-year history
Answer: C
Conceptual Explanation: The current USPSTF recommendation for lung cancer screening
is annual LDCT for adults aged 50 to 80 years who have a 20 pack-year smoking history
and currently smoke or have quit within the past 15 years.
5. A patient with newly diagnosed Multiple Myeloma presents with anemia, renal
insufficiency, and lytic bone lesions. Which criteria are these symptoms part of?
A. RECIST criteria
B. CRAB criteria
C. Gleason score
D. R-IPI score
Answer: B
Conceptual Explanation: CRAB stands for Calcium elevation, Renal insufficiency, Anemia,
and Bone abnormalities, which are the classic markers of end-organ damage in Multiple
Myeloma.
6. What is the primary mechanism of action of Trastuzumab deruxtecan (Enhertu)?
A. Inhibition of VEGF receptors
B. PD-L1 checkpoint blockade
VERIFIED ANSWERS (A+ GUARANTEE)
2026/2027
1. A patient with metastatic melanoma is identified as having a BRAF V600E mutation. Which
of the following is the most appropriate initial targeted therapy combination?
A. Pembrolizumab and Ipilimumab
B. Dabrafenib and Trametinib
C. Vemurafenib and Rituximab
D. Olaparib and Bevacizumab
Answer: B
Conceptual Explanation: Dabrafenib is a BRAF inhibitor and Trametinib is a MEK
inhibitor. The combination is standard for BRAF V600E-mutated melanoma to delay the
onset of resistance.
2. Which of the following electrolyte abnormalities is characteristic of Tumor Lysis Syndrome
(TLS)?
A. Hypercalcemia and Hypokalemia
B. Hypouricemia and Hypermagnesemia
C. Hyperuricemia, Hyperphosphatemia, and Hyperkalemia
,D. Hyponatremia and Hypophosphatemia
Answer: C
Conceptual Explanation: TLS involves the rapid release of intracellular contents, leading
to high levels of uric acid, potassium, and phosphorus, which subsequently causes
hypocalcemia.
3. An oncology NP is managing a patient on Pembrolizumab who presents with Grade 2
immune-related pneumonitis. What is the recommended management?
A. Continue Pembrolizumab and observe
B. Permanently discontinue Pembrolizumab immediately
C. Withhold therapy and initiate 1-2 mg/kg/day of prednisone
D. Administer prophylactic antibiotics and resume therapy next week
Answer: C
Conceptual Explanation: For Grade 2 pneumonitis, immunotherapy should be withheld,
and corticosteroids (prednisone 1-2 mg/kg/day) should be started. Therapy may be
resumed only if symptoms resolve to Grade 0-1 after a taper.
4. According to the USPSTF guidelines updated for 2021/2022, what is the age range and
smoking history required for annual low-dose CT lung cancer screening?
A. Ages 45-75 with a 15 pack-year history
B. Ages 50-80 with a 30 pack-year history
, C. Ages 50-80 with a 20 pack-year history
D. Ages 55-80 with a 30 pack-year history
Answer: C
Conceptual Explanation: The current USPSTF recommendation for lung cancer screening
is annual LDCT for adults aged 50 to 80 years who have a 20 pack-year smoking history
and currently smoke or have quit within the past 15 years.
5. A patient with newly diagnosed Multiple Myeloma presents with anemia, renal
insufficiency, and lytic bone lesions. Which criteria are these symptoms part of?
A. RECIST criteria
B. CRAB criteria
C. Gleason score
D. R-IPI score
Answer: B
Conceptual Explanation: CRAB stands for Calcium elevation, Renal insufficiency, Anemia,
and Bone abnormalities, which are the classic markers of end-organ damage in Multiple
Myeloma.
6. What is the primary mechanism of action of Trastuzumab deruxtecan (Enhertu)?
A. Inhibition of VEGF receptors
B. PD-L1 checkpoint blockade
