D345
PSYCHOPHARMACOLOGY
Substance-Use & Addiction
Pharmacotherapy
100-Question Practice Test
100 A-D 100%
QUESTIONS OPTIONS EXPLAINED
Alcohol Use Disorder • Opioid Use Disorder • Overdose Safety
Tobacco Cessation • Withdrawal • Monitoring • Patient Teaching
PASSPOINTPRO
,D345 | SUBSTANCE-USE & ADDICTION PHARMACOTHERAPY
How to Use This Test
This focused practice test reviews substance-use and addiction pharmacotherapy within D345
Psychopharmacology. Each item is followed immediately by the correct answer and a concise explanation so
you can use the test for active recall, remediation, and rapid review.
Core emphasis Medication selection, mechanisms, safety, withdrawal, overdose prevention,
interactions, monitoring, and patient teaching
Question style Clinical application + high-yield medication knowledge
Format 100 multiple-choice questions, A-D, answer and explanation after every item
Study tip: Cover the answer box, commit to an option, then compare your reasoning with the explanation. Flag
recurring weak areas for targeted review.
Alcohol Use Disorder Pharmacotherapy
1. A patient with alcohol use disorder wants a medication that can reduce the rewarding
effects of alcohol and craving. Which medication best fits this goal?
A. Acamprosate
B. Naltrexone
C. Disulfiram
D. Diazepam
Answer: B
Explanation: Naltrexone is an opioid receptor antagonist used for alcohol use disorder and can reduce
craving and the rewarding effects of alcohol. Acamprosate is used primarily to support maintenance of
abstinence, while disulfiram produces an aversive reaction if alcohol is consumed.
2. Which medication for alcohol use disorder is most closely associated with supporting
abstinence by modulating glutamatergic and GABA-related signaling after alcohol
cessation?
A. Acamprosate
B. Buprenorphine
C. Methadone
D. Varenicline
Answer: A
Explanation: Acamprosate is used to help maintain abstinence in alcohol use disorder and is thought to
reduce the hyperexcitability associated with prolonged abstinence. It is not used to treat opioid or nicotine
dependence.
3. A patient taking disulfiram drinks alcohol. Which reaction is most expected?
A. Euphoria and sedation
B. Flushing, nausea, and palpitations
C. Profound analgesia
D. Bradykinesia and rigidity
Answer: B
Explanation: Disulfiram inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation when alcohol
is consumed. The resulting reaction may include flushing, nausea, vomiting, headache, palpitations, and
hypotension.
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, D345 | SUBSTANCE-USE & ADDICTION PHARMACOTHERAPY
4. Which patient teaching is most important before starting disulfiram?
A. Avoid only beer; wine is safe
B. Alcohol-containing products can also trigger a reaction
C. Take the medication only when craving occurs
D. Stop the drug abruptly if mild nausea develops
Answer: B
Explanation: Patients taking disulfiram should avoid alcohol from beverages and hidden sources such as
some mouthwashes, sauces, and liquid medications. Even small amounts can provoke an unpleasant
disulfiram-alcohol reaction.
5. A patient with alcohol use disorder is currently taking prescription opioids for pain.
Which medication would generally require special caution because it can block opioid
effects?
A. Acamprosate
B. Naltrexone
C. Disulfiram
D. Thiamine
Answer: B
Explanation: Naltrexone blocks opioid receptors and can interfere with opioid analgesia or precipitate
withdrawal in a physiologically opioid-dependent patient. Opioid use status must therefore be assessed
before initiation.
6. Which feature makes acamprosate especially useful to remember when selecting among
medications for alcohol use disorder?
A. It is primarily eliminated by the kidneys
B. It is a full opioid agonist
C. It causes alcohol intoxication
D. It reverses opioid overdose
Answer: A
Explanation: Acamprosate is largely renally eliminated, so renal function is important when considering its
use. It does not act as an opioid agonist and does not reverse overdose.
7. Which laboratory or clinical concern is especially relevant before and during treatment
with naltrexone?
A. Hepatic function
B. Visual acuity only
C. Serum lithium level
D. Absolute neutrophil count only
Answer: A
Explanation: Naltrexone is metabolized hepatically, so liver disease and hepatic function are clinically
relevant. Monitoring should be individualized to the patient, dose, formulation, and comorbidities.
8. Which medication is an aversive therapy rather than a craving-reduction or
abstinence-support medication?
A. Disulfiram
B. Acamprosate
PassPointPro | Focused Practice Test Page 2
PSYCHOPHARMACOLOGY
Substance-Use & Addiction
Pharmacotherapy
100-Question Practice Test
100 A-D 100%
QUESTIONS OPTIONS EXPLAINED
Alcohol Use Disorder • Opioid Use Disorder • Overdose Safety
Tobacco Cessation • Withdrawal • Monitoring • Patient Teaching
PASSPOINTPRO
,D345 | SUBSTANCE-USE & ADDICTION PHARMACOTHERAPY
How to Use This Test
This focused practice test reviews substance-use and addiction pharmacotherapy within D345
Psychopharmacology. Each item is followed immediately by the correct answer and a concise explanation so
you can use the test for active recall, remediation, and rapid review.
Core emphasis Medication selection, mechanisms, safety, withdrawal, overdose prevention,
interactions, monitoring, and patient teaching
Question style Clinical application + high-yield medication knowledge
Format 100 multiple-choice questions, A-D, answer and explanation after every item
Study tip: Cover the answer box, commit to an option, then compare your reasoning with the explanation. Flag
recurring weak areas for targeted review.
Alcohol Use Disorder Pharmacotherapy
1. A patient with alcohol use disorder wants a medication that can reduce the rewarding
effects of alcohol and craving. Which medication best fits this goal?
A. Acamprosate
B. Naltrexone
C. Disulfiram
D. Diazepam
Answer: B
Explanation: Naltrexone is an opioid receptor antagonist used for alcohol use disorder and can reduce
craving and the rewarding effects of alcohol. Acamprosate is used primarily to support maintenance of
abstinence, while disulfiram produces an aversive reaction if alcohol is consumed.
2. Which medication for alcohol use disorder is most closely associated with supporting
abstinence by modulating glutamatergic and GABA-related signaling after alcohol
cessation?
A. Acamprosate
B. Buprenorphine
C. Methadone
D. Varenicline
Answer: A
Explanation: Acamprosate is used to help maintain abstinence in alcohol use disorder and is thought to
reduce the hyperexcitability associated with prolonged abstinence. It is not used to treat opioid or nicotine
dependence.
3. A patient taking disulfiram drinks alcohol. Which reaction is most expected?
A. Euphoria and sedation
B. Flushing, nausea, and palpitations
C. Profound analgesia
D. Bradykinesia and rigidity
Answer: B
Explanation: Disulfiram inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation when alcohol
is consumed. The resulting reaction may include flushing, nausea, vomiting, headache, palpitations, and
hypotension.
PassPointPro | Focused Practice Test Page 1
, D345 | SUBSTANCE-USE & ADDICTION PHARMACOTHERAPY
4. Which patient teaching is most important before starting disulfiram?
A. Avoid only beer; wine is safe
B. Alcohol-containing products can also trigger a reaction
C. Take the medication only when craving occurs
D. Stop the drug abruptly if mild nausea develops
Answer: B
Explanation: Patients taking disulfiram should avoid alcohol from beverages and hidden sources such as
some mouthwashes, sauces, and liquid medications. Even small amounts can provoke an unpleasant
disulfiram-alcohol reaction.
5. A patient with alcohol use disorder is currently taking prescription opioids for pain.
Which medication would generally require special caution because it can block opioid
effects?
A. Acamprosate
B. Naltrexone
C. Disulfiram
D. Thiamine
Answer: B
Explanation: Naltrexone blocks opioid receptors and can interfere with opioid analgesia or precipitate
withdrawal in a physiologically opioid-dependent patient. Opioid use status must therefore be assessed
before initiation.
6. Which feature makes acamprosate especially useful to remember when selecting among
medications for alcohol use disorder?
A. It is primarily eliminated by the kidneys
B. It is a full opioid agonist
C. It causes alcohol intoxication
D. It reverses opioid overdose
Answer: A
Explanation: Acamprosate is largely renally eliminated, so renal function is important when considering its
use. It does not act as an opioid agonist and does not reverse overdose.
7. Which laboratory or clinical concern is especially relevant before and during treatment
with naltrexone?
A. Hepatic function
B. Visual acuity only
C. Serum lithium level
D. Absolute neutrophil count only
Answer: A
Explanation: Naltrexone is metabolized hepatically, so liver disease and hepatic function are clinically
relevant. Monitoring should be individualized to the patient, dose, formulation, and comorbidities.
8. Which medication is an aversive therapy rather than a craving-reduction or
abstinence-support medication?
A. Disulfiram
B. Acamprosate
PassPointPro | Focused Practice Test Page 2
